KRA71_HUMAN
ID KRA71_HUMAN Reviewed; 87 AA.
AC Q8IUC3; Q3LI56;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Keratin-associated protein 7-1;
DE AltName: Full=High tyrosine-glycine keratin-associated protein 7.1;
GN Name=KRTAP7-1; Synonyms=KAP7.1, KRTAP7.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Scalp;
RX PubMed=12359730; DOI=10.1074/jbc.m206422200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Schweizer J.;
RT "Characterization of a first domain of human high glycine-tyrosine and high
RT sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1.";
RL J. Biol. Chem. 277:48993-49002(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q8IUC3; Q03989: ARID5A; NbExp=3; IntAct=EBI-18394498, EBI-948603;
CC Q8IUC3; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-18394498, EBI-946029;
CC Q8IUC3; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-18394498, EBI-12139335;
CC Q8IUC3; Q02930-3: CREB5; NbExp=3; IntAct=EBI-18394498, EBI-10192698;
CC Q8IUC3; P53672: CRYBA2; NbExp=3; IntAct=EBI-18394498, EBI-750444;
CC Q8IUC3; Q86UW9: DTX2; NbExp=3; IntAct=EBI-18394498, EBI-740376;
CC Q8IUC3; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-18394498, EBI-11978259;
CC Q8IUC3; O75593: FOXH1; NbExp=3; IntAct=EBI-18394498, EBI-1759806;
CC Q8IUC3; P23769: GATA2; NbExp=3; IntAct=EBI-18394498, EBI-2806671;
CC Q8IUC3; O75603: GCM2; NbExp=3; IntAct=EBI-18394498, EBI-10188645;
CC Q8IUC3; O14964: HGS; NbExp=3; IntAct=EBI-18394498, EBI-740220;
CC Q8IUC3; P52597: HNRNPF; NbExp=3; IntAct=EBI-18394498, EBI-352986;
CC Q8IUC3; Q13064: MKRN3; NbExp=3; IntAct=EBI-18394498, EBI-2340269;
CC Q8IUC3; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-18394498, EBI-5662487;
CC Q8IUC3; P32242: OTX1; NbExp=3; IntAct=EBI-18394498, EBI-740446;
CC Q8IUC3; P78337: PITX1; NbExp=3; IntAct=EBI-18394498, EBI-748265;
CC Q8IUC3; Q99697-2: PITX2; NbExp=3; IntAct=EBI-18394498, EBI-12138495;
CC Q8IUC3; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-18394498, EBI-740924;
CC Q8IUC3; P20618: PSMB1; NbExp=3; IntAct=EBI-18394498, EBI-372273;
CC Q8IUC3; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-18394498, EBI-372094;
CC Q8IUC3; Q9H0F5: RNF38; NbExp=3; IntAct=EBI-18394498, EBI-2341200;
CC Q8IUC3; Q01974: ROR2; NbExp=3; IntAct=EBI-18394498, EBI-6422642;
CC Q8IUC3; Q9H0F6-2: SHARPIN; NbExp=3; IntAct=EBI-18394498, EBI-9843813;
CC Q8IUC3; Q92922: SMARCC1; NbExp=3; IntAct=EBI-18394498, EBI-355653;
CC Q8IUC3; P09234: SNRPC; NbExp=3; IntAct=EBI-18394498, EBI-766589;
CC Q8IUC3; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-18394498, EBI-11959123;
CC Q8IUC3; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-18394498, EBI-11746252;
CC Q8IUC3; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-18394498, EBI-750487;
CC Q8IUC3; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-18394498, EBI-11952651;
CC Q8IUC3; Q08117-2: TLE5; NbExp=3; IntAct=EBI-18394498, EBI-11741437;
CC Q8IUC3; O43711: TLX3; NbExp=3; IntAct=EBI-18394498, EBI-3939165;
CC Q8IUC3; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-18394498, EBI-74615;
CC Q8IUC3; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-18394498, EBI-2559305;
CC Q8IUC3; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-18394498, EBI-1051237;
CC Q8IUC3; Q15915: ZIC1; NbExp=3; IntAct=EBI-18394498, EBI-11963196;
CC Q8IUC3; A0A384ME25; NbExp=3; IntAct=EBI-18394498, EBI-10211777;
CC -!- TISSUE SPECIFICITY: Expressed in the upper portion of the hair cortex.
CC -!- SIMILARITY: Belongs to the KRTAP type 7 family. {ECO:0000305}.
CC -!- CAUTION: The sequence of 1-36 of PubMed:12359730 has not been
CC submitted. {ECO:0000305}.
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DR EMBL; AJ457063; CAD29719.1; -; mRNA.
DR EMBL; AB096962; BAE46377.1; -; mRNA.
DR EMBL; AP001709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS74780.1; -.
DR RefSeq; NP_853637.2; NM_181606.2.
DR AlphaFoldDB; Q8IUC3; -.
DR BioGRID; 130624; 37.
DR IntAct; Q8IUC3; 36.
DR STRING; 9606.ENSP00000479656; -.
DR PhosphoSitePlus; Q8IUC3; -.
DR BioMuta; KRTAP7-1; -.
DR MassIVE; Q8IUC3; -.
DR PeptideAtlas; Q8IUC3; -.
DR PRIDE; Q8IUC3; -.
DR ProteomicsDB; 70542; -.
DR DNASU; 337878; -.
DR Ensembl; ENST00000621162.1; ENSP00000479656.1; ENSG00000274749.1.
DR GeneID; 337878; -.
DR KEGG; hsa:337878; -.
DR MANE-Select; ENST00000621162.1; ENSP00000479656.1; NM_181606.3; NP_853637.2.
DR UCSC; uc032pxy.2; human.
DR CTD; 337878; -.
DR GeneCards; KRTAP7-1; -.
DR HGNC; HGNC:18934; KRTAP7-1.
DR HPA; ENSG00000274749; Tissue enriched (skin).
DR neXtProt; NX_Q8IUC3; -.
DR OpenTargets; ENSG00000274749; -.
DR PharmGKB; PA134993282; -.
DR VEuPathDB; HostDB:ENSG00000274749; -.
DR eggNOG; ENOG502TDVI; Eukaryota.
DR GeneTree; ENSGT00390000015202; -.
DR HOGENOM; CLU_2482768_0_0_1; -.
DR InParanoid; Q8IUC3; -.
DR OMA; FCCGNYF; -.
DR OrthoDB; 1591532at2759; -.
DR PhylomeDB; Q8IUC3; -.
DR PathwayCommons; Q8IUC3; -.
DR SignaLink; Q8IUC3; -.
DR BioGRID-ORCS; 337878; 4 hits in 165 CRISPR screens.
DR GenomeRNAi; 337878; -.
DR Pharos; Q8IUC3; Tdark.
DR PRO; PR:Q8IUC3; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q8IUC3; protein.
DR Bgee; ENSG00000274749; Expressed in amniotic fluid and 23 other tissues.
DR Genevisible; Q8IUC3; HS.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR020184; KRTAP7.
DR PANTHER; PTHR38504; PTHR38504; 1.
DR Pfam; PF15034; KRTAP7; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..87
FT /note="Keratin-associated protein 7-1"
FT /id="PRO_0000185182"
FT REGION 43..84
FT /note="11 X 2 AA repeats of G-[YCGS]"
SQ SEQUENCE 87 AA; 9288 MW; D08DB80A2D0DC033 CRC64;
MTRYFCCGSY FPGYPIYGTN FHGTFRATPL NCVVPLGSPL NYGCGCNGYS SLGYSFGGSN
INNLGGCYGG SFYRPWGSGS GFGYSTY
