KRA71_MOUSE
ID KRA71_MOUSE Reviewed; 87 AA.
AC Q9D3I6;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Keratin-associated protein 7-1;
DE AltName: Full=High glycine-tyrosine keratin-associated protein 7.1;
GN Name=Krtap7-1; Synonyms=Kap7.1, Krtap7.1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- SIMILARITY: Belongs to the KRTAP type 7 family. {ECO:0000305}.
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DR EMBL; AK017387; BAB30724.1; -; mRNA.
DR CCDS; CCDS49902.1; -.
DR RefSeq; NP_082047.1; NM_027771.1.
DR AlphaFoldDB; Q9D3I6; -.
DR STRING; 10090.ENSMUSP00000054720; -.
DR iPTMnet; Q9D3I6; -.
DR PhosphoSitePlus; Q9D3I6; -.
DR PaxDb; Q9D3I6; -.
DR PRIDE; Q9D3I6; -.
DR ProteomicsDB; 263566; -.
DR Ensembl; ENSMUST00000056118; ENSMUSP00000054720; ENSMUSG00000056706.
DR GeneID; 71363; -.
DR KEGG; mmu:71363; -.
DR UCSC; uc012aib.1; mouse.
DR CTD; 337878; -.
DR MGI; MGI:1918613; Krtap7-1.
DR VEuPathDB; HostDB:ENSMUSG00000056706; -.
DR eggNOG; ENOG502TDVI; Eukaryota.
DR GeneTree; ENSGT00390000015202; -.
DR HOGENOM; CLU_2482768_0_0_1; -.
DR InParanoid; Q9D3I6; -.
DR OMA; FCCGNYF; -.
DR OrthoDB; 1591532at2759; -.
DR PhylomeDB; Q9D3I6; -.
DR TreeFam; TF339788; -.
DR BioGRID-ORCS; 71363; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9D3I6; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9D3I6; protein.
DR Bgee; ENSMUSG00000056706; Expressed in lip and 9 other tissues.
DR Genevisible; Q9D3I6; MM.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR020184; KRTAP7.
DR PANTHER; PTHR38504; PTHR38504; 1.
DR Pfam; PF15034; KRTAP7; 1.
PE 3: Inferred from homology;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..87
FT /note="Keratin-associated protein 7-1"
FT /id="PRO_0000185183"
FT REGION 37..84
FT /note="8 X 2 AA repeats of G-[YCGS]"
SQ SEQUENCE 87 AA; 9516 MW; 6A57FC91D63E799A CRC64;
MTRYFCCGNY FPGYPCYGTN FHGTYRATPL NCVVPLGSPL NHGCGTMYSS RNFCYGGISN
FSNPGCCYGS SLYRPWGSGS GFGYSTY
