ID   KRA71_SHEEP             Reviewed;          85 AA.
AC   Q28580;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Keratin-associated protein 7-1;
DE   AltName: Full=HGT keratin;
DE   AltName: Full=HGT-C2;
DE   AltName: Full=High glycine-tyrosine keratin-associated protein 7.1;
GN   Name=KRTAP7-1; Synonyms=HGTC2;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Merino;
RX   PubMed=2439340; DOI=10.1111/j.1432-1033.1987.tb13486.x;
RA   Kuczek E.S., Rogers G.E.;
RT   "Sheep wool (glycine + tyrosine)-rich keratin genes. A family of low
RT   sequence homology.";
RL   Eur. J. Biochem. 166:79-85(1987).
CC   -!- FUNCTION: In the wool cortex, wool keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant wool shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of wool keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with wool keratins.
CC   -!- TISSUE SPECIFICITY: Wool.
CC   -!- SIMILARITY: Belongs to the KRTAP type 7 family. {ECO:0000305}.
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DR   EMBL; X05638; CAA29125.1; -; Genomic_DNA.
DR   PIR; S00071; S00071.
DR   RefSeq; XP_004002822.1; XM_004002773.3.
DR   AlphaFoldDB; Q28580; -.
DR   STRING; 9940.ENSOARP00000008521; -.
DR   Ensembl; ENSOART00000008645; ENSOARP00000008521; ENSOARG00000007941.
DR   Ensembl; ENSOART00020002173; ENSOARP00020001813; ENSOARG00020001442.
DR   GeneID; 101104027; -.
DR   KEGG; oas:101104027; -.
DR   eggNOG; ENOG502TDVI; Eukaryota.
DR   HOGENOM; CLU_2482768_0_0_1; -.
DR   OMA; FCCGNYF; -.
DR   OrthoDB; 1591532at2759; -.
DR   Proteomes; UP000002356; Chromosome 1.
DR   ExpressionAtlas; Q28580; baseline.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR020184; KRTAP7.
DR   PANTHER; PTHR38504; PTHR38504; 1.
DR   Pfam; PF15034; KRTAP7; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..85
FT                   /note="Keratin-associated protein 7-1"
FT                   /id="PRO_0000185184"
FT   REGION          37..82
FT                   /note="12 X 2 AA repeats of G-[YCGS]"
SQ   SEQUENCE   85 AA;  9078 MW;  5CE0E3A7A6B12CE6 CRC64;
     MTRFFCCGSY FPGYPSYGTN FHRTFRATPL NCVVPLGSPL GYGCNGYSSL GYGFGGSSFS
     NLGCGYGGSF YRPWGSGSGF GYSTY