KRA81_MOUSE
ID KRA81_MOUSE Reviewed; 61 AA.
AC O08633; Q3UZQ1;
DT 27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Keratin-associated protein 8-1;
DE AltName: Full=HGTp type I F;
DE AltName: Full=High-glycine/tyrosine protein keratin;
DE Short=HGT keratin;
GN Name=Krtap8-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-61.
RC TISSUE=Skin;
RX PubMed=9374545; DOI=10.1074/jbc.272.48.30512;
RA Aoki N., Ito K., Ito M.;
RT "Isolation and characterization of mouse high-glycine/tyrosine proteins.";
RL J. Biol. Chem. 272:30512-30518(1997).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- TISSUE SPECIFICITY: Expression restricted exclusively to the cortical
CC cells of hair follicles.
CC -!- SIMILARITY: Belongs to the KRTAP type 8 family. {ECO:0000305}.
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DR EMBL; AK133727; BAE21804.1; -; mRNA.
DR EMBL; D86423; BAA19684.1; -; mRNA.
DR CCDS; CCDS49901.1; -.
DR RefSeq; NP_034805.1; NM_010675.1.
DR AlphaFoldDB; O08633; -.
DR STRING; 10090.ENSMUSP00000072129; -.
DR PaxDb; O08633; -.
DR PRIDE; O08633; -.
DR ProteomicsDB; 264800; -.
DR Antibodypedia; 6687; 55 antibodies from 13 providers.
DR Ensembl; ENSMUST00000072280; ENSMUSP00000072129; ENSMUSG00000059632.
DR GeneID; 16703; -.
DR KEGG; mmu:16703; -.
DR UCSC; uc007zvr.2; mouse.
DR CTD; 337879; -.
DR MGI; MGI:1330293; Krtap8-1.
DR VEuPathDB; HostDB:ENSMUSG00000059632; -.
DR eggNOG; ENOG502SW61; Eukaryota.
DR GeneTree; ENSGT00530000064274; -.
DR HOGENOM; CLU_3019710_0_0_1; -.
DR InParanoid; O08633; -.
DR OMA; RRYWPYA; -.
DR OrthoDB; 1624842at2759; -.
DR PhylomeDB; O08633; -.
DR TreeFam; TF338337; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 16703; 6 hits in 73 CRISPR screens.
DR PRO; PR:O08633; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; O08633; protein.
DR Bgee; ENSMUSG00000059632; Expressed in lip and 16 other tissues.
DR Genevisible; O08633; MM.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR039351; KRTAP8-1.
DR PANTHER; PTHR36131; PTHR36131; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..61
FT /note="Keratin-associated protein 8-1"
FT /id="PRO_0000185186"
FT REGION 13..49
FT /note="11 X 2 AA repeats of G-[YCGS]"
FT CONFLICT 42
FT /note="L -> F (in Ref. 2; BAA19684)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 61 AA; 6697 MW; 6D1EE0FD2BE24A73 CRC64;
MYYTGAEGSV FPGCYWGSYG YPLGYSVGCG YGSTYSPVGY GLGYGYNGCG AYRRYWPFAL
Y
