ID   KRA81_SHEEP             Reviewed;          62 AA.
AC   P02448; Q28581; Q28750;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Keratin-associated protein 8-1;
DE   AltName: Full=Component 0.62;
DE   AltName: Full=HGT keratin;
DE   AltName: Full=HGT keratin component F;
DE   AltName: Full=Keratin, high-tyrosine matrix protein;
GN   Name=KRTAP8-1; Synonyms=HGT;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Merino;
RX   PubMed=2439340; DOI=10.1111/j.1432-1033.1987.tb13486.x;
RA   Kuczek E.S., Rogers G.E.;
RT   "Sheep wool (glycine + tyrosine)-rich keratin genes. A family of low
RT   sequence homology.";
RL   Eur. J. Biochem. 166:79-85(1987).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-62.
RC   STRAIN=Merino;
RX   PubMed=4735656; DOI=10.1111/j.1432-1033.1973.tb02737.x;
RA   Dopheide T.A.A.;
RT   "The primary structure of a protein, component 0.62, rich in glycine and
RT   aromatic residues, obtained from wool keratin.";
RL   Eur. J. Biochem. 34:120-124(1973).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 15-62.
RC   STRAIN=Merino;
RX   PubMed=2578389; DOI=10.1111/j.1432-1033.1985.tb08623.x;
RA   Kuczek E.S., Rogers G.E.;
RT   "Sheep keratins: characterization of cDNA clones for the glycine +
RT   tyrosine-rich wool proteins using a synthetic probe.";
RL   Eur. J. Biochem. 146:89-93(1985).
CC   -!- FUNCTION: In the wool cortex, wool keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant wool shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of wool keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with wool keratins.
CC   -!- TISSUE SPECIFICITY: Wool.
CC   -!- SIMILARITY: Belongs to the KRTAP type 8 family. {ECO:0000305}.
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DR   EMBL; X05639; CAA29126.1; -; Genomic_DNA.
DR   EMBL; M28304; AAA31536.1; -; mRNA.
DR   PIR; S00031; KRSHI6.
DR   AlphaFoldDB; P02448; -.
DR   STRING; 9940.ENSOARP00000000675; -.
DR   Ensembl; ENSOART00020002187; ENSOARP00020001826; ENSOARG00020001446.
DR   eggNOG; ENOG502SW61; Eukaryota.
DR   OMA; RRYWPYA; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR039351; KRTAP8-1.
DR   PANTHER; PTHR36131; PTHR36131; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Keratin; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:4735656"
FT   CHAIN           2..62
FT                   /note="Keratin-associated protein 8-1"
FT                   /id="PRO_0000185187"
FT   REGION          12..53
FT                   /note="12 X 2 AA repeats of G-[YCGS]"
FT   CONFLICT        46..49
FT                   /note="NGSG -> DGGS (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        51
FT                   /note="F -> S (in Ref. 1; CAA29126)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   62 AA;  6791 MW;  104BA872AF47A974 CRC64;
     MSYCFSSTVF PGCYWGSYGY PLGYSVGCGY GSTYSPVGYG FGYGYNGSGA FGCRRFWPFA
     LY