KRA91_HUMAN
ID KRA91_HUMAN Reviewed; 250 AA.
AC A8MXZ3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Keratin-associated protein 9-1 {ECO:0000305};
DE AltName: Full=Keratin-associated protein 9-like 3 {ECO:0000312|HGNC:HGNC:18912};
GN Name=KRTAP9-1 {ECO:0000312|HGNC:HGNC:18912};
GN Synonyms=KAP9.1, KRTAP9.1, KRTAP9L3 {ECO:0000312|HGNC:HGNC:18912};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KRTAP type 9 family. {ECO:0000305}.
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DR EMBL; AC006070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS56029.1; -.
DR RefSeq; NP_001177389.1; NM_001190460.1.
DR AlphaFoldDB; A8MXZ3; -.
DR BioGRID; 608746; 1.
DR STRING; 9606.ENSP00000381488; -.
DR iPTMnet; A8MXZ3; -.
DR PhosphoSitePlus; A8MXZ3; -.
DR BioMuta; KRTAP9-1; -.
DR MassIVE; A8MXZ3; -.
DR PaxDb; A8MXZ3; -.
DR PeptideAtlas; A8MXZ3; -.
DR PRIDE; A8MXZ3; -.
DR ProteomicsDB; 2365; -.
DR DNASU; 728318; -.
DR Ensembl; ENST00000398470.1; ENSP00000381488.1; ENSG00000240542.5.
DR GeneID; 728318; -.
DR KEGG; hsa:728318; -.
DR MANE-Select; ENST00000398470.1; ENSP00000381488.1; NM_001190460.1; NP_001177389.1.
DR UCSC; uc021txf.1; human.
DR CTD; 728318; -.
DR GeneCards; KRTAP9-1; -.
DR HGNC; HGNC:18912; KRTAP9-1.
DR HPA; ENSG00000240542; Not detected.
DR neXtProt; NX_A8MXZ3; -.
DR PharmGKB; PA134939475; -.
DR VEuPathDB; HostDB:ENSG00000240542; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000165697; -.
DR HOGENOM; CLU_113141_0_0_1; -.
DR InParanoid; A8MXZ3; -.
DR OMA; PSCGCNG; -.
DR PhylomeDB; A8MXZ3; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; A8MXZ3; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; A8MXZ3; -.
DR BioGRID-ORCS; 728318; 11 hits in 1028 CRISPR screens.
DR GenomeRNAi; 728318; -.
DR Pharos; A8MXZ3; Tdark.
DR PRO; PR:A8MXZ3; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A8MXZ3; protein.
DR Bgee; ENSG00000240542; Expressed in granulocyte and 8 other tissues.
DR ExpressionAtlas; A8MXZ3; baseline and differential.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF13885; Keratin_B2_2; 3.
PE 3: Inferred from homology;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..250
FT /note="Keratin-associated protein 9-1"
FT /id="PRO_0000332261"
FT REPEAT 8..12
FT /note="1"
FT REPEAT 13..17
FT /note="2"
FT REPEAT 18..22
FT /note="3"
FT REPEAT 37..41
FT /note="4"
FT REPEAT 42..46
FT /note="5"
FT REPEAT 51..55
FT /note="6"
FT REPEAT 56..60
FT /note="7"
FT REPEAT 61..65
FT /note="8"
FT REPEAT 66..70
FT /note="9"
FT REPEAT 75..79
FT /note="10"
FT REPEAT 80..84
FT /note="11"
FT REPEAT 85..89
FT /note="12"
FT REPEAT 90..94
FT /note="13"
FT REPEAT 95..99
FT /note="14"
FT REPEAT 105..109
FT /note="15"
FT REPEAT 114..117
FT /note="16"
FT REPEAT 118..121
FT /note="17"
FT REPEAT 133..137
FT /note="18"
FT REPEAT 138..142
FT /note="19"
FT REPEAT 143..147
FT /note="20"
FT REPEAT 153..157
FT /note="21"
FT REPEAT 162..166
FT /note="22"
FT REPEAT 167..171
FT /note="23"
FT REPEAT 176..180
FT /note="24"
FT REPEAT 185..189
FT /note="25"
FT REPEAT 190..194
FT /note="26"
FT REPEAT 214..218
FT /note="27"
FT REPEAT 219..223
FT /note="28"
FT REPEAT 229..233
FT /note="29"
FT REPEAT 234..238
FT /note="30"
FT REPEAT 239..243
FT /note="31"
FT REPEAT 244..248
FT /note="32"
FT REGION 8..248
FT /note="32 X 5 AA repeats of C-C-[CGSVRQH]-[SQTNP]-[PTSI]"
SQ SEQUENCE 250 AA; 26333 MW; 38CEDE3EF8F2ACF2 CRC64;
MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP SCCVPSCCQP CCHPTCCQNT
CCRTTCCQPT CVASCCQPSC CSTPCCQPTC CGSSCCGQTS CGSSCCQPIC GSSCCQPCCH
PTCYQTICFR TTCCQPTCCQ PTCCRNTSCQ PTCCGSSCCQ PCCHPTCCQT ICRSTCCQPS
CVTRCCSTPC CQPTCGGSSC CSQTCNESSY CLPCCRPTCC QTTCYRTTCC RPSCCCSPCC
VSSCCQPSCC
