KRA93_HUMAN
ID KRA93_HUMAN Reviewed; 159 AA.
AC Q9BYQ3;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Keratin-associated protein 9-3;
DE AltName: Full=Keratin-associated protein 9.3;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 9.3;
GN Name=KRTAP9-3; Synonyms=KAP9.3, KRTAP9.3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q9BYQ3; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-1043191, EBI-10173507;
CC Q9BYQ3; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-1043191, EBI-11954519;
CC Q9BYQ3; Q86V38: ATN1; NbExp=3; IntAct=EBI-1043191, EBI-11954292;
CC Q9BYQ3; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-1043191, EBI-3866279;
CC Q9BYQ3; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-1043191, EBI-744545;
CC Q9BYQ3; Q8TC90: CCER1; NbExp=3; IntAct=EBI-1043191, EBI-746041;
CC Q9BYQ3; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-1043191, EBI-12139335;
CC Q9BYQ3; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-1043191, EBI-12261896;
CC Q9BYQ3; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-1043191, EBI-947551;
CC Q9BYQ3; P07510-2: CHRNG; NbExp=3; IntAct=EBI-1043191, EBI-11979451;
CC Q9BYQ3; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-1043191, EBI-741032;
CC Q9BYQ3; P27658: COL8A1; NbExp=3; IntAct=EBI-1043191, EBI-747133;
CC Q9BYQ3; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-1043191, EBI-713677;
CC Q9BYQ3; Q02930-3: CREB5; NbExp=3; IntAct=EBI-1043191, EBI-10192698;
CC Q9BYQ3; P06850: CRH; NbExp=3; IntAct=EBI-1043191, EBI-3870390;
CC Q9BYQ3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-1043191, EBI-3867333;
CC Q9BYQ3; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-1043191, EBI-10303987;
CC Q9BYQ3; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-1043191, EBI-9679045;
CC Q9BYQ3; Q92608: DOCK2; NbExp=3; IntAct=EBI-1043191, EBI-448771;
CC Q9BYQ3; Q16610: ECM1; NbExp=3; IntAct=EBI-1043191, EBI-947964;
CC Q9BYQ3; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-1043191, EBI-11986315;
CC Q9BYQ3; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-1043191, EBI-719816;
CC Q9BYQ3; Q969U6: FBXW5; NbExp=3; IntAct=EBI-1043191, EBI-741068;
CC Q9BYQ3; Q7L5D6: GET4; NbExp=3; IntAct=EBI-1043191, EBI-711823;
CC Q9BYQ3; O76003: GLRX3; NbExp=3; IntAct=EBI-1043191, EBI-374781;
CC Q9BYQ3; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-1043191, EBI-11975289;
CC Q9BYQ3; P49639: HOXA1; NbExp=8; IntAct=EBI-1043191, EBI-740785;
CC Q9BYQ3; P31269: HOXA9; NbExp=3; IntAct=EBI-1043191, EBI-742314;
CC Q9BYQ3; Q0VD86: INCA1; NbExp=3; IntAct=EBI-1043191, EBI-6509505;
CC Q9BYQ3; P16144-2: ITGB4; NbExp=3; IntAct=EBI-1043191, EBI-11051601;
CC Q9BYQ3; Q15040: JOSD1; NbExp=3; IntAct=EBI-1043191, EBI-2510602;
CC Q9BYQ3; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-1043191, EBI-6426443;
CC Q9BYQ3; Q15323: KRT31; NbExp=3; IntAct=EBI-1043191, EBI-948001;
CC Q9BYQ3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-1043191, EBI-11959885;
CC Q9BYQ3; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-1043191, EBI-11749135;
CC Q9BYQ3; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-1043191, EBI-11955579;
CC Q9BYQ3; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-1043191, EBI-10217483;
CC Q9BYQ3; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-1043191, EBI-10172150;
CC Q9BYQ3; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-1043191, EBI-10172290;
CC Q9BYQ3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-1043191, EBI-10171774;
CC Q9BYQ3; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-1043191, EBI-10172052;
CC Q9BYQ3; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-1043191, EBI-1052037;
CC Q9BYQ3; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-1043191, EBI-10210845;
CC Q9BYQ3; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-1043191, EBI-10176379;
CC Q9BYQ3; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-1043191, EBI-10241252;
CC Q9BYQ3; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-1043191, EBI-12196745;
CC Q9BYQ3; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-1043191, EBI-12805508;
CC Q9BYQ3; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-1043191, EBI-14065470;
CC Q9BYQ3; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-1043191, EBI-9996449;
CC Q9BYQ3; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-1043191, EBI-751260;
CC Q9BYQ3; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-1043191, EBI-3957694;
CC Q9BYQ3; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-1043191, EBI-11957260;
CC Q9BYQ3; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-1043191, EBI-739863;
CC Q9BYQ3; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-1043191, EBI-10172511;
CC Q9BYQ3; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-1043191, EBI-11958132;
CC Q9BYQ3; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-1043191, EBI-11993254;
CC Q9BYQ3; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-1043191, EBI-11993296;
CC Q9BYQ3; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-1043191, EBI-11974251;
CC Q9BYQ3; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-1043191, EBI-11963072;
CC Q9BYQ3; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-1043191, EBI-10250562;
CC Q9BYQ3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-1043191, EBI-3958099;
CC Q9BYQ3; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-1043191, EBI-1044640;
CC Q9BYQ3; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-1043191, EBI-1043191;
CC Q9BYQ3; Q9BYQ0: KRTAP9-8; NbExp=6; IntAct=EBI-1043191, EBI-11958364;
CC Q9BYQ3; Q5T7P2: LCE1A; NbExp=6; IntAct=EBI-1043191, EBI-11962058;
CC Q9BYQ3; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-1043191, EBI-10245913;
CC Q9BYQ3; Q5T751: LCE1C; NbExp=3; IntAct=EBI-1043191, EBI-12224199;
CC Q9BYQ3; Q5T752: LCE1D; NbExp=4; IntAct=EBI-1043191, EBI-11741311;
CC Q9BYQ3; Q5T753: LCE1E; NbExp=3; IntAct=EBI-1043191, EBI-11955335;
CC Q9BYQ3; Q5T754: LCE1F; NbExp=6; IntAct=EBI-1043191, EBI-11958008;
CC Q9BYQ3; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-1043191, EBI-10246607;
CC Q9BYQ3; O14633: LCE2B; NbExp=3; IntAct=EBI-1043191, EBI-11478468;
CC Q9BYQ3; Q5TA81: LCE2C; NbExp=6; IntAct=EBI-1043191, EBI-11973993;
CC Q9BYQ3; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-1043191, EBI-10246750;
CC Q9BYQ3; Q5TA76: LCE3A; NbExp=8; IntAct=EBI-1043191, EBI-9394625;
CC Q9BYQ3; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-1043191, EBI-11974495;
CC Q9BYQ3; Q5T5A8: LCE3C; NbExp=6; IntAct=EBI-1043191, EBI-10245291;
CC Q9BYQ3; Q9BYE3: LCE3D; NbExp=6; IntAct=EBI-1043191, EBI-6658837;
CC Q9BYQ3; Q5T5B0: LCE3E; NbExp=6; IntAct=EBI-1043191, EBI-10245456;
CC Q9BYQ3; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-1043191, EBI-10246358;
CC Q9BYQ3; Q5TCM9: LCE5A; NbExp=6; IntAct=EBI-1043191, EBI-11955689;
CC Q9BYQ3; Q8IXW0: LMNTD2; NbExp=3; IntAct=EBI-1043191, EBI-12028858;
CC Q9BYQ3; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-1043191, EBI-739832;
CC Q9BYQ3; O60336: MAPKBP1; NbExp=3; IntAct=EBI-1043191, EBI-947402;
CC Q9BYQ3; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-1043191, EBI-16439278;
CC Q9BYQ3; Q9NQS3-2: NECTIN3; NbExp=3; IntAct=EBI-1043191, EBI-12106440;
CC Q9BYQ3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-1043191, EBI-22310682;
CC Q9BYQ3; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-1043191, EBI-748927;
CC Q9BYQ3; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-1043191, EBI-10250949;
CC Q9BYQ3; Q92570: NR4A3; NbExp=3; IntAct=EBI-1043191, EBI-13644623;
CC Q9BYQ3; Q9P121-3: NTM; NbExp=3; IntAct=EBI-1043191, EBI-12027160;
CC Q9BYQ3; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-1043191, EBI-1210753;
CC Q9BYQ3; P32242: OTX1; NbExp=3; IntAct=EBI-1043191, EBI-740446;
CC Q9BYQ3; Q02548: PAX5; NbExp=3; IntAct=EBI-1043191, EBI-296331;
CC Q9BYQ3; P26367: PAX6; NbExp=3; IntAct=EBI-1043191, EBI-747278;
CC Q9BYQ3; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-1043191, EBI-14084211;
CC Q9BYQ3; Q12837: POU4F2; NbExp=3; IntAct=EBI-1043191, EBI-17236143;
CC Q9BYQ3; O43741: PRKAB2; NbExp=3; IntAct=EBI-1043191, EBI-1053424;
CC Q9BYQ3; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-1043191, EBI-7199479;
CC Q9BYQ3; P15151: PVR; NbExp=3; IntAct=EBI-1043191, EBI-3919694;
CC Q9BYQ3; O60896: RAMP3; NbExp=3; IntAct=EBI-1043191, EBI-720447;
CC Q9BYQ3; O76081-6: RGS20; NbExp=3; IntAct=EBI-1043191, EBI-10178530;
CC Q9BYQ3; Q9NR46: SH3GLB2; NbExp=3; IntAct=EBI-1043191, EBI-749607;
CC Q9BYQ3; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-1043191, EBI-11955083;
CC Q9BYQ3; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-1043191, EBI-12002412;
CC Q9BYQ3; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-1043191, EBI-11998660;
CC Q9BYQ3; Q9H1K4: SLC25A18; NbExp=3; IntAct=EBI-1043191, EBI-6269587;
CC Q9BYQ3; P49901: SMCP; NbExp=6; IntAct=EBI-1043191, EBI-750494;
CC Q9BYQ3; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-1043191, EBI-10269322;
CC Q9BYQ3; O43609: SPRY1; NbExp=3; IntAct=EBI-1043191, EBI-3866665;
CC Q9BYQ3; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-1043191, EBI-11952651;
CC Q9BYQ3; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-1043191, EBI-5235829;
CC Q9BYQ3; O14817: TSPAN4; NbExp=3; IntAct=EBI-1043191, EBI-8652667;
CC Q9BYQ3; Q13432: UNC119; NbExp=3; IntAct=EBI-1043191, EBI-711260;
CC Q9BYQ3; Q6EMK4: VASN; NbExp=6; IntAct=EBI-1043191, EBI-10249550;
CC Q9BYQ3; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-1043191, EBI-11957216;
CC Q9BYQ3; O96014: WNT11; NbExp=3; IntAct=EBI-1043191, EBI-8058160;
CC Q9BYQ3; P25490: YY1; NbExp=3; IntAct=EBI-1043191, EBI-765538;
CC Q9BYQ3; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-1043191, EBI-744257;
CC Q9BYQ3; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-1043191, EBI-747580;
CC Q9BYQ3; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-1043191, EBI-726439;
CC Q9BYQ3; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-1043191, EBI-10486136;
CC Q9BYQ3; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-1043191, EBI-14069183;
CC -!- SIMILARITY: Belongs to the KRTAP type 9 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ406947; CAC27586.1; -; mRNA.
DR EMBL; BC074918; AAH74918.1; -; mRNA.
DR EMBL; BC074919; AAH74919.1; -; mRNA.
DR CCDS; CCDS11385.1; -.
DR RefSeq; NP_114168.1; NM_031962.2.
DR AlphaFoldDB; Q9BYQ3; -.
DR BioGRID; 123811; 131.
DR IntAct; Q9BYQ3; 122.
DR STRING; 9606.ENSP00000392189; -.
DR BioMuta; KRTAP9-3; -.
DR DMDM; 38372388; -.
DR MassIVE; Q9BYQ3; -.
DR PaxDb; Q9BYQ3; -.
DR PeptideAtlas; Q9BYQ3; -.
DR PRIDE; Q9BYQ3; -.
DR ProteomicsDB; 79683; -.
DR DNASU; 83900; -.
DR Ensembl; ENST00000411528.4; ENSP00000392189.2; ENSG00000204873.5.
DR Ensembl; ENST00000571096.2; ENSP00000458819.1; ENSG00000262749.2.
DR GeneID; 83900; -.
DR KEGG; hsa:83900; -.
DR MANE-Select; ENST00000411528.4; ENSP00000392189.2; NM_031962.3; NP_114168.1.
DR UCSC; uc021txg.1; human.
DR CTD; 83900; -.
DR GeneCards; KRTAP9-3; -.
DR HGNC; HGNC:16927; KRTAP9-3.
DR HPA; ENSG00000204873; Tissue enriched (skin).
DR neXtProt; NX_Q9BYQ3; -.
DR OpenTargets; ENSG00000204873; -.
DR PharmGKB; PA38425; -.
DR VEuPathDB; HostDB:ENSG00000204873; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000156135; -.
DR HOGENOM; CLU_113141_2_0_1; -.
DR InParanoid; Q9BYQ3; -.
DR OMA; SLCWNPH; -.
DR PhylomeDB; Q9BYQ3; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; Q9BYQ3; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYQ3; -.
DR BioGRID-ORCS; 83900; 10 hits in 996 CRISPR screens.
DR GenomeRNAi; 83900; -.
DR Pharos; Q9BYQ3; Tdark.
DR PRO; PR:Q9BYQ3; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYQ3; protein.
DR Bgee; ENSG00000204873; Expressed in skin of abdomen and 19 other tissues.
DR Genevisible; Q9BYQ3; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF13885; Keratin_B2_2; 3.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..159
FT /note="Keratin-associated protein 9-3"
FT /id="PRO_0000185189"
FT REPEAT 8..12
FT /note="1"
FT REPEAT 13..17
FT /note="2"
FT REPEAT 32..36
FT /note="3"
FT REPEAT 37..41
FT /note="4"
FT REPEAT 46..50
FT /note="5"
FT REPEAT 51..55
FT /note="6"
FT REPEAT 56..60
FT /note="7"
FT REPEAT 61..65
FT /note="8"
FT REPEAT 70..74
FT /note="9"
FT REPEAT 75..79
FT /note="10"
FT REPEAT 80..84
FT /note="11"
FT REPEAT 85..89
FT /note="12"
FT REPEAT 129..133
FT /note="13"
FT REPEAT 134..138
FT /note="14"
FT REPEAT 139..143
FT /note="15"
FT REPEAT 153..157
FT /note="16"
FT REGION 8..157
FT /note="16 X 5 AA repeats of C-C-[RQVSHE]-[SPTN]-[TASPI]"
SQ SEQUENCE 159 AA; 16854 MW; 375CC1E52EECDE68 CRC64;
MTHCCSPCCQ PTCCRTTCWQ PTTVTTCSST PCCQPSCCVS SCCQPCCHPT CCQNTCCRTT
CCQPICVTSC CQPSCCSTPC CQPTCCGSSC GQSSSCAPVY CRRTCYHPTS VCLPGCLNQS
CGSNCCQPCC RPACCETTCC RTTCFQPTCV YSCCQPSCC
