KRA93_MOUSE
ID KRA93_MOUSE Reviewed; 136 AA.
AC Q3V2C1; Q9D718;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Keratin-associated protein 9-3 {ECO:0000312|EMBL:CAM19187.1};
DE AltName: Full=Keratin-associated protein 9.3;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 9.3;
GN Name=Krtap9-3 {ECO:0000312|MGI:MGI:1922836};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAE20877.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE20877.1};
RC TISSUE=Tongue {ECO:0000312|EMBL:BAE20877.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KRTAP type 9 family.
CC {ECO:0000250|UniProtKB:Q9BYQ3}.
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DR EMBL; AK009730; BAB26467.1; -; mRNA.
DR EMBL; AK131927; BAE20877.1; -; mRNA.
DR EMBL; AL591417; CAM19187.1; -; Genomic_DNA.
DR CCDS; CCDS36311.1; -.
DR RefSeq; NP_083627.2; NM_029351.2.
DR AlphaFoldDB; Q3V2C1; -.
DR STRING; 10090.ENSMUSP00000057445; -.
DR PaxDb; Q3V2C1; -.
DR PRIDE; Q3V2C1; -.
DR DNASU; 75586; -.
DR Ensembl; ENSMUST00000062683; ENSMUSP00000057445; ENSMUSG00000049809.
DR GeneID; 75586; -.
DR KEGG; mmu:75586; -.
DR UCSC; uc007ljf.1; mouse.
DR CTD; 83900; -.
DR MGI; MGI:1922836; Krtap9-3.
DR VEuPathDB; HostDB:ENSMUSG00000049809; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000160295; -.
DR HOGENOM; CLU_109417_0_0_1; -.
DR InParanoid; Q3V2C1; -.
DR OMA; PSYCETS; -.
DR PhylomeDB; Q3V2C1; -.
DR TreeFam; TF351356; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 75586; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q3V2C1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q3V2C1; protein.
DR Bgee; ENSMUSG00000049809; Expressed in lip and 29 other tissues.
DR Genevisible; Q3V2C1; MM.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF01500; Keratin_B2; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..136
FT /note="Keratin-associated protein 9-3"
FT /id="PRO_0000361043"
FT REPEAT 3..7
FT /note="1"
FT REPEAT 21..25
FT /note="2"
FT REPEAT 31..35
FT /note="3"
FT REPEAT 36..40
FT /note="4"
FT REPEAT 41..45
FT /note="5"
FT REPEAT 46..50
FT /note="6"
FT REPEAT 87..91
FT /note="7"
FT REPEAT 97..101
FT /note="8"
FT REPEAT 107..111
FT /note="9"
FT REPEAT 117..121
FT /note="10"
FT REPEAT 126..130
FT /note="11"
FT REGION 21..130
FT /note="11 X 5 AA repeats of C-C-[AEQVR]-[ALPTV]-[AGHST]"
FT CONFLICT 71
FT /note="R -> K (in Ref. 1; BAB26467)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="S -> F (in Ref. 1; BAB26467)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 136 AA; 13902 MW; CAB99FEDAED15EDF CRC64;
MACCATSFCG FPTCSTGGSS CCQPTCTQSS CCQPSCCEAS CCQPSCCETG FGGGIGCGQE
GGSGGVSCRV RWCRPDCRVE GTCLPPCCVV SCTPPTCCQL HHAQASCCRP SYCGQSCCRP
ACCCYCCQPS CSEPSC
