KRA96_HUMAN
ID KRA96_HUMAN Reviewed; 160 AA.
AC A8MVA2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Keratin-associated protein 9-6 {ECO:0000305};
DE AltName: Full=Keratin-associated protein 9-like 2 {ECO:0000312|HGNC:HGNC:18914};
GN Name=KRTAP9-6 {ECO:0000312|HGNC:HGNC:18914};
GN Synonyms=KAP9.6, KRTAP9.6, KRTAP9L2 {ECO:0000312|HGNC:HGNC:18914};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KRTAP type 9 family. {ECO:0000305}.
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DR EMBL; AC006070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59286.1; -.
DR RefSeq; NP_001264260.1; NM_001277331.1.
DR AlphaFoldDB; A8MVA2; -.
DR STRING; 9606.ENSP00000375150; -.
DR BioMuta; KRTAP9-6; -.
DR MassIVE; A8MVA2; -.
DR PaxDb; A8MVA2; -.
DR PeptideAtlas; A8MVA2; -.
DR PRIDE; A8MVA2; -.
DR DNASU; 100507608; -.
DR Ensembl; ENST00000391355.1; ENSP00000375150.1; ENSG00000212659.1.
DR Ensembl; ENST00000576511.1; ENSP00000460691.1; ENSG00000263263.1.
DR GeneID; 100507608; -.
DR KEGG; hsa:100507608; -.
DR MANE-Select; ENST00000391355.2; ENSP00000375150.1; NM_001277331.1; NP_001264260.1.
DR UCSC; uc031rag.2; human.
DR CTD; 100507608; -.
DR GeneCards; KRTAP9-6; -.
DR HGNC; HGNC:18914; KRTAP9-6.
DR HPA; ENSG00000212659; Tissue enriched (skin).
DR neXtProt; NX_A8MVA2; -.
DR VEuPathDB; HostDB:ENSG00000212659; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000156135; -.
DR HOGENOM; CLU_113141_2_0_1; -.
DR InParanoid; A8MVA2; -.
DR OMA; CCSETCC; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; A8MVA2; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR BioGRID-ORCS; 100507608; 118 hits in 987 CRISPR screens.
DR Pharos; A8MVA2; Tdark.
DR PRO; PR:A8MVA2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A8MVA2; protein.
DR Bgee; ENSG00000212659; Expressed in skin of abdomen and 2 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF13885; Keratin_B2_2; 1.
PE 3: Inferred from homology;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..160
FT /note="Keratin-associated protein 9-6"
FT /id="PRO_0000332260"
FT REPEAT 4..8
FT /note="1"
FT REPEAT 13..17
FT /note="2"
FT REPEAT 18..22
FT /note="3"
FT REPEAT 37..41
FT /note="4"
FT REPEAT 42..46
FT /note="5"
FT REPEAT 47..51
FT /note="6"
FT REPEAT 56..60
FT /note="7"
FT REPEAT 61..65
FT /note="8"
FT REPEAT 66..70
FT /note="9"
FT REPEAT 75..79
FT /note="10"
FT REPEAT 80..84
FT /note="11"
FT REPEAT 90..94
FT /note="12"
FT REPEAT 95..99
FT /note="13"
FT REPEAT 140..144
FT /note="14"
FT REPEAT 149..153
FT /note="15"
FT REPEAT 154..158
FT /note="16"
FT REGION 4..158
FT /note="16 X 5 AA repeats of C-C-[GSVRQ]-[QTSPHN]-[TPSGYC]"
FT VARIANT 86
FT /note="Y -> C (in dbSNP:rs12938692)"
FT /id="VAR_042997"
SQ SEQUENCE 160 AA; 16800 MW; CB6254D9E7B2CA15 CRC64;
MTHCCSPGCQ PTCCRTTCCR TTCWQPTIVT TCSSTPCCQP SCCVSSCCQP YCHPTCCQNT
CCRTTCCQPT CVTSCCQPSC CSTPCYQPIC CGSSCCGQTS CGSSCGQSSS CAPVYCRRTC
YHPTTVCLPG CLNQSCGSSC CQPCYCPACC VSSCCQHSCC