KRA97_HUMAN
ID KRA97_HUMAN Reviewed; 169 AA.
AC A8MTY7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Keratin-associated protein 9-7 {ECO:0000305};
DE AltName: Full=Keratin-associated protein 9-like 1 {ECO:0000312|HGNC:HGNC:18915};
GN Name=KRTAP9-7 {ECO:0000312|HGNC:HGNC:18915};
GN Synonyms=KAP9.7, KRTAP9.7, KRTAP9L1 {ECO:0000312|HGNC:HGNC:18915};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KRTAP type 9 family. {ECO:0000305}.
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DR EMBL; AC006070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59287.1; -.
DR RefSeq; NP_001264261.1; NM_001277332.1.
DR AlphaFoldDB; A8MTY7; -.
DR BioGRID; 124441; 1.
DR STRING; 9606.ENSP00000375149; -.
DR BioMuta; KRTAP9-7; -.
DR MassIVE; A8MTY7; -.
DR PaxDb; A8MTY7; -.
DR PeptideAtlas; A8MTY7; -.
DR PRIDE; A8MTY7; -.
DR DNASU; 100505724; -.
DR Ensembl; ENST00000391354.1; ENSP00000375149.1; ENSG00000180386.7.
DR Ensembl; ENST00000573531.1; ENSP00000460369.1; ENSG00000262221.1.
DR GeneID; 100505724; -.
DR KEGG; hsa:100505724; -.
DR MANE-Select; ENST00000391354.2; ENSP00000375149.1; NM_001277332.1; NP_001264261.1.
DR UCSC; uc031rah.2; human.
DR CTD; 100505724; -.
DR GeneCards; KRTAP9-7; -.
DR HGNC; HGNC:18915; KRTAP9-7.
DR HPA; ENSG00000180386; Tissue enriched (skin).
DR neXtProt; NX_A8MTY7; -.
DR VEuPathDB; HostDB:ENSG00000180386; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000156135; -.
DR HOGENOM; CLU_113141_0_0_1; -.
DR InParanoid; A8MTY7; -.
DR OMA; KDPACKD; -.
DR PhylomeDB; A8MTY7; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; A8MTY7; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; A8MTY7; -.
DR BioGRID-ORCS; 100505724; 11 hits in 984 CRISPR screens.
DR GenomeRNAi; 100505724; -.
DR Pharos; A8MTY7; Tdark.
DR PRO; PR:A8MTY7; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A8MTY7; protein.
DR Bgee; ENSG00000180386; Expressed in skin of abdomen and 6 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF13885; Keratin_B2_2; 3.
PE 3: Inferred from homology;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..169
FT /note="Keratin-associated protein 9-7"
FT /id="PRO_0000332259"
FT REPEAT 8..12
FT /note="1"
FT REPEAT 13..17
FT /note="2"
FT REPEAT 32..36
FT /note="3"
FT REPEAT 37..41
FT /note="4"
FT REPEAT 46..50
FT /note="5"
FT REPEAT 51..55
FT /note="6"
FT REPEAT 56..60
FT /note="7"
FT REPEAT 61..65
FT /note="8"
FT REPEAT 75..79
FT /note="9"
FT REPEAT 80..84
FT /note="10"
FT REPEAT 85..89
FT /note="11"
FT REPEAT 90..94
FT /note="12"
FT REPEAT 100..104
FT /note="13"
FT REPEAT 139..143
FT /note="14"
FT REPEAT 144..148
FT /note="15"
FT REPEAT 149..153
FT /note="16"
FT REPEAT 163..167
FT /note="17"
FT REGION 8..167
FT /note="17 X 5 AA repeats of C-C-[VGSREQH]-[SQTPN]-[STPAI]"
FT VARIANT 23
FT /note="T -> I (in dbSNP:rs4890107)"
FT /id="VAR_042995"
FT VARIANT 130
FT /note="S -> N (in dbSNP:rs12948628)"
FT /id="VAR_042996"
SQ SEQUENCE 169 AA; 17793 MW; 17320FA5E5159495 CRC64;
MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCHPT CCQNTCCRTT
CCQPTCVTSC CQPSCCSTPC CQPICCGSSC CGQTSCGSSC CQPSSCAPIY CRRTCYHPTS
VYLPGCLNQS CGSSCCQPCC RPACCETTCC RTTCFQPTCV TSCCQPACC
