KRA98_HUMAN
ID KRA98_HUMAN Reviewed; 159 AA.
AC Q9BYQ0;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Keratin-associated protein 9-8;
DE AltName: Full=Keratin-associated protein 9.8;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 9.8;
GN Name=KRTAP9-8; Synonyms=KAP9.8, KRTAP9.8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q9BYQ0; O43184-4: ADAM12; NbExp=3; IntAct=EBI-11958364, EBI-12006944;
CC Q9BYQ0; P29972: AQP1; NbExp=3; IntAct=EBI-11958364, EBI-745213;
CC Q9BYQ0; P18075: BMP7; NbExp=3; IntAct=EBI-11958364, EBI-1035195;
CC Q9BYQ0; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11958364, EBI-744545;
CC Q9BYQ0; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-11958364, EBI-12139335;
CC Q9BYQ0; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-11958364, EBI-741032;
CC Q9BYQ0; Q02930-3: CREB5; NbExp=5; IntAct=EBI-11958364, EBI-10192698;
CC Q9BYQ0; Q49AN0: CRY2; NbExp=3; IntAct=EBI-11958364, EBI-2212355;
CC Q9BYQ0; A8MQ03: CYSRT1; NbExp=7; IntAct=EBI-11958364, EBI-3867333;
CC Q9BYQ0; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-11958364, EBI-746300;
CC Q9BYQ0; O96015: DNAL4; NbExp=3; IntAct=EBI-11958364, EBI-742362;
CC Q9BYQ0; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-11958364, EBI-719816;
CC Q9BYQ0; O76003: GLRX3; NbExp=3; IntAct=EBI-11958364, EBI-374781;
CC Q9BYQ0; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-11958364, EBI-11975289;
CC Q9BYQ0; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-11958364, EBI-11978177;
CC Q9BYQ0; P49639: HOXA1; NbExp=8; IntAct=EBI-11958364, EBI-740785;
CC Q9BYQ0; Q2WGJ6: KLHL38; NbExp=5; IntAct=EBI-11958364, EBI-6426443;
CC Q9BYQ0; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11958364, EBI-11959885;
CC Q9BYQ0; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11958364, EBI-11749135;
CC Q9BYQ0; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11958364, EBI-10172150;
CC Q9BYQ0; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11958364, EBI-10172290;
CC Q9BYQ0; P60410: KRTAP10-8; NbExp=5; IntAct=EBI-11958364, EBI-10171774;
CC Q9BYQ0; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11958364, EBI-1052037;
CC Q9BYQ0; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11958364, EBI-10176379;
CC Q9BYQ0; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11958364, EBI-11988175;
CC Q9BYQ0; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11958364, EBI-14065470;
CC Q9BYQ0; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-11958364, EBI-3957672;
CC Q9BYQ0; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-11958364, EBI-9996449;
CC Q9BYQ0; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11958364, EBI-3957694;
CC Q9BYQ0; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-11958364, EBI-11957260;
CC Q9BYQ0; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11958364, EBI-10302392;
CC Q9BYQ0; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11958364, EBI-10172511;
CC Q9BYQ0; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11958364, EBI-11958132;
CC Q9BYQ0; Q6L8G4: KRTAP5-11; NbExp=6; IntAct=EBI-11958364, EBI-11993296;
CC Q9BYQ0; Q6L8G9: KRTAP5-6; NbExp=4; IntAct=EBI-11958364, EBI-10250562;
CC Q9BYQ0; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-11958364, EBI-3958099;
CC Q9BYQ0; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11958364, EBI-1044640;
CC Q9BYQ0; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-11958364, EBI-1043191;
CC Q9BYQ0; Q5T7P2: LCE1A; NbExp=6; IntAct=EBI-11958364, EBI-11962058;
CC Q9BYQ0; Q5T7P3: LCE1B; NbExp=5; IntAct=EBI-11958364, EBI-10245913;
CC Q9BYQ0; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11958364, EBI-12224199;
CC Q9BYQ0; Q5T752: LCE1D; NbExp=3; IntAct=EBI-11958364, EBI-11741311;
CC Q9BYQ0; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11958364, EBI-11955335;
CC Q9BYQ0; Q5T754: LCE1F; NbExp=6; IntAct=EBI-11958364, EBI-11958008;
CC Q9BYQ0; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-11958364, EBI-10246607;
CC Q9BYQ0; O14633: LCE2B; NbExp=6; IntAct=EBI-11958364, EBI-11478468;
CC Q9BYQ0; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11958364, EBI-11973993;
CC Q9BYQ0; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11958364, EBI-10246750;
CC Q9BYQ0; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-11958364, EBI-9394625;
CC Q9BYQ0; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11958364, EBI-11974495;
CC Q9BYQ0; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11958364, EBI-6658837;
CC Q9BYQ0; Q5T5B0: LCE3E; NbExp=5; IntAct=EBI-11958364, EBI-10245456;
CC Q9BYQ0; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11958364, EBI-10246358;
CC Q9BYQ0; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11958364, EBI-739832;
CC Q9BYQ0; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11958364, EBI-16439278;
CC Q9BYQ0; Q969G9: NKD1; NbExp=3; IntAct=EBI-11958364, EBI-1538217;
CC Q9BYQ0; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11958364, EBI-22310682;
CC Q9BYQ0; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-11958364, EBI-10250949;
CC Q9BYQ0; Q92570: NR4A3; NbExp=3; IntAct=EBI-11958364, EBI-13644623;
CC Q9BYQ0; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-11958364, EBI-741158;
CC Q9BYQ0; Q9Y5Y2: NUBP2; NbExp=3; IntAct=EBI-11958364, EBI-1048886;
CC Q9BYQ0; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-11958364, EBI-1210753;
CC Q9BYQ0; P61970: NUTF2; NbExp=3; IntAct=EBI-11958364, EBI-591778;
CC Q9BYQ0; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-11958364, EBI-10225049;
CC Q9BYQ0; P32242: OTX1; NbExp=3; IntAct=EBI-11958364, EBI-740446;
CC Q9BYQ0; P07237: P4HB; NbExp=3; IntAct=EBI-11958364, EBI-395883;
CC Q9BYQ0; P26367: PAX6; NbExp=3; IntAct=EBI-11958364, EBI-747278;
CC Q9BYQ0; A2BDE7: PHLDA1; NbExp=5; IntAct=EBI-11958364, EBI-14084211;
CC Q9BYQ0; Q12837: POU4F2; NbExp=3; IntAct=EBI-11958364, EBI-17236143;
CC Q9BYQ0; O43741: PRKAB2; NbExp=8; IntAct=EBI-11958364, EBI-1053424;
CC Q9BYQ0; P54619: PRKAG1; NbExp=3; IntAct=EBI-11958364, EBI-1181439;
CC Q9BYQ0; O76081-6: RGS20; NbExp=3; IntAct=EBI-11958364, EBI-10178530;
CC Q9BYQ0; O76064: RNF8; NbExp=3; IntAct=EBI-11958364, EBI-373337;
CC Q9BYQ0; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-11958364, EBI-12002412;
CC Q9BYQ0; Q8IY34: SLC15A3; NbExp=3; IntAct=EBI-11958364, EBI-12179023;
CC Q9BYQ0; P49901: SMCP; NbExp=6; IntAct=EBI-11958364, EBI-750494;
CC Q9BYQ0; Q13432: UNC119; NbExp=3; IntAct=EBI-11958364, EBI-711260;
CC Q9BYQ0; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11958364, EBI-10249550;
CC Q9BYQ0; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-11958364, EBI-11957216;
CC Q9BYQ0; Q9GZM5: YIPF3; NbExp=3; IntAct=EBI-11958364, EBI-743787;
CC Q9BYQ0; P25490: YY1; NbExp=5; IntAct=EBI-11958364, EBI-765538;
CC Q9BYQ0; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11958364, EBI-625509;
CC -!- SIMILARITY: Belongs to the KRTAP type 9 family. {ECO:0000305}.
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DR EMBL; AJ406950; CAC27589.1; -; mRNA.
DR EMBL; AC006070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC074981; AAH74981.1; -; mRNA.
DR EMBL; BC074982; AAH74982.1; -; mRNA.
DR CCDS; CCDS42334.1; -.
DR RefSeq; NP_114169.2; NM_031963.2.
DR RefSeq; XP_016855212.1; XM_016999723.1.
DR AlphaFoldDB; Q9BYQ0; -.
DR BioGRID; 123812; 87.
DR IntAct; Q9BYQ0; 82.
DR STRING; 9606.ENSP00000254072; -.
DR iPTMnet; Q9BYQ0; -.
DR PhosphoSitePlus; Q9BYQ0; -.
DR BioMuta; KRTAP9-8; -.
DR DMDM; 296434559; -.
DR MassIVE; Q9BYQ0; -.
DR PaxDb; Q9BYQ0; -.
DR PeptideAtlas; Q9BYQ0; -.
DR PRIDE; Q9BYQ0; -.
DR Antibodypedia; 76595; 2 antibodies from 2 providers.
DR DNASU; 83901; -.
DR Ensembl; ENST00000254072.7; ENSP00000254072.6; ENSG00000187272.7.
DR GeneID; 83901; -.
DR KEGG; hsa:83901; -.
DR MANE-Select; ENST00000254072.7; ENSP00000254072.6; NM_031963.3; NP_114169.2.
DR UCSC; uc002hwh.5; human.
DR CTD; 83901; -.
DR GeneCards; KRTAP9-8; -.
DR HGNC; HGNC:17231; KRTAP9-8.
DR HPA; ENSG00000187272; Tissue enriched (skin).
DR neXtProt; NX_Q9BYQ0; -.
DR PharmGKB; PA38443; -.
DR VEuPathDB; HostDB:ENSG00000187272; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000156135; -.
DR InParanoid; Q9BYQ0; -.
DR OMA; CHFNSDC; -.
DR PhylomeDB; Q9BYQ0; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; Q9BYQ0; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYQ0; -.
DR BioGRID-ORCS; 83901; 22 hits in 985 CRISPR screens.
DR GenomeRNAi; 83901; -.
DR Pharos; Q9BYQ0; Tdark.
DR PRO; PR:Q9BYQ0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYQ0; protein.
DR Bgee; ENSG00000187272; Expressed in skin of abdomen and 25 other tissues.
DR Genevisible; Q9BYQ0; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF13885; Keratin_B2_2; 3.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..159
FT /note="Keratin-associated protein 9-8"
FT /id="PRO_0000185192"
FT REPEAT 8..12
FT /note="1"
FT REPEAT 13..17
FT /note="2"
FT REPEAT 32..36
FT /note="3"
FT REPEAT 37..41
FT /note="4"
FT REPEAT 46..50
FT /note="5"
FT REPEAT 51..55
FT /note="6"
FT REPEAT 56..60
FT /note="7"
FT REPEAT 65..69
FT /note="8"
FT REPEAT 70..74
FT /note="9"
FT REPEAT 75..79
FT /note="10"
FT REPEAT 80..84
FT /note="11"
FT REPEAT 129..133
FT /note="12"
FT REPEAT 134..138
FT /note="13"
FT REPEAT 139..142
FT /note="14"
FT REPEAT 153..157
FT /note="15"
FT REGION 8..157
FT /note="15 X 5 AA repeats of C-C-[RQVSGE]-[SPSNQ]-[TASPI]"
FT CONFLICT 124
FT /note="N -> S (in Ref. 1; CAC27589 and 3; AAH74981/
FT AAH74982)"
FT /evidence="ECO:0000305"
FT CONFLICT 151
FT /note="S -> Y (in Ref. 1; CAC27589 and 3; AAH74981/
FT AAH74982)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 16723 MW; 4954E7F712A87BBE CRC64;
MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCRPT CCQNTCCQPI
CVTSCCQPSC CSTPCCQPTC CGQTSCGSSC GQSSSCAPVY CRRTCYHPTT VCLPGCLNQS
CGSNCCQPCC RPACCETTCC RTTCFQPTCV SSCCQPSCC
