ID   KRB2A_SHEEP             Reviewed;         172 AA.
AC   P02438;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Keratin, high-sulfur matrix protein, B2A;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6193483; DOI=10.1093/nar/11.16.5327;
RA   Powell B.C., Sleigh M.J., Ward K.A., Rogers G.E.;
RT   "Mammalian keratin gene families: organisation of genes coding for the B2
RT   high-sulphur proteins of sheep wool.";
RL   Nucleic Acids Res. 11:5327-5346(1983).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-172, AND ACETYLATION AT ALA-2.
RX   PubMed=4679226; DOI=10.1042/bj1300833;
RA   Elleman T.C.;
RT   "The amino acid sequence of protein SCMK-B2A from the high-sulphur fraction
RT   of wool keratin.";
RL   Biochem. J. 130:833-845(1972).
CC   -!- FUNCTION: The keratin products of mammalian epidermal derivatives such
CC       as wool and hair consist of microfibrils embedded in a rigid matrix of
CC       other proteins. The matrix proteins include the high-sulfur and high-
CC       tyrosine keratins, having molecular weights of 6-20 kDa, whereas the
CC       microfibrils contain the larger, low-sulfur keratins (40-56 kDa).
CC   -!- MISCELLANEOUS: The source of this keratin is lincoln wool.
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DR   EMBL; X01610; CAA25757.1; -; Genomic_DNA.
DR   PIR; S07910; KRSHHA.
DR   AlphaFoldDB; P02438; -.
DR   STRING; 9940.ENSOARP00000016860; -.
DR   iPTMnet; P02438; -.
DR   PRIDE; P02438; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 2.
DR   Pfam; PF01500; Keratin_B2; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Keratin; Reference proteome;
KW   Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:4679226"
FT   CHAIN           2..172
FT                   /note="Keratin, high-sulfur matrix protein, B2A"
FT                   /id="PRO_0000084324"
FT   REPEAT          27..36
FT   REPEAT          37..46
FT   REPEAT          47..56
FT   REPEAT          57..66
FT   REPEAT          67..76
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:4679226"
FT   VARIANT         13
FT                   /note="I -> T (in minor component)"
FT   VARIANT         23
FT                   /note="S -> N (in minor component)"
FT   VARIANT         24
FT                   /note="P -> F (in minor component)"
SQ   SEQUENCE   172 AA;  17734 MW;  9B6056E19159C040 CRC64;
     MACCSTSFCG FPICSTGGTC GSSPCQPTCC QTSCCQPTSI QTSCCQPISI QTSCCQPTSI
     QTSCCQPTCL QTSGCETGCG IGGSIGYGQV GSSGAVSSRT RWCRPDCRVE GTSLPPCCVV
     SCTPPSCCQL YYAQASCCRP SYCGQSCCRP ACCCQPTCIE PICEPSCCEP TC