ID   KRB2B_SHEEP             Reviewed;         156 AA.
AC   P02439;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Keratin, high-sulfur matrix protein, B2B;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE, AND ACETYLATION AT ALA-1.
RX   PubMed=4555954; DOI=10.1016/s0021-9258(19)45120-x;
RA   Elleman T.C., Dopheide T.A.;
RT   "The sequence of SCMK-B2B, a high-sulfur protein from wool keratin.";
RL   J. Biol. Chem. 247:3900-3909(1972).
CC   -!- FUNCTION: The keratin products of mammalian epidermal derivatives such
CC       as wool and hair consist of microfibrils embedded in a rigid matrix of
CC       other proteins. The matrix proteins include the high-sulfur and high-
CC       tyrosine keratins, having molecular weights of 6-20 kDa, whereas the
CC       microfibrils contain the larger, low-sulfur keratins (40-56 kDa).
CC   -!- MISCELLANEOUS: The source of this keratin is lincoln wool.
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DR   PIR; A02838; KRSHHB.
DR   AlphaFoldDB; P02439; -.
DR   iPTMnet; P02439; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 2.
DR   Pfam; PF01500; Keratin_B2; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Keratin; Reference proteome;
KW   Repeat.
FT   CHAIN           1..156
FT                   /note="Keratin, high-sulfur matrix protein, B2B"
FT                   /id="PRO_0000084325"
FT   REPEAT          26..35
FT   REPEAT          36..45
FT   REPEAT          46..55
FT   REPEAT          56..65
FT   MOD_RES         1
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:4555954"
FT   VARIANT         77
FT                   /note="D -> G (in minor component)"
SQ   SEQUENCE   156 AA;  16040 MW;  EE549ADCF1F1FB39 CRC64;
     ACCSTSFCGF PICSSVGTCG SSCGQPTCSQ TSCCQPTSIQ TSCCQPISIQ TSCCQPTCLQ
     TSGCETGCGI GGSIGYDQVG SSGAVSSRTR WCRPDCRVEG TSLPPCCVVS CTSPSCCQLY
     YAQASCCRPS YCGQSCCRPA CCCQPTCIEP VCEPTC