ID   KRB2C_SHEEP             Reviewed;         152 AA.
AC   P02440;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Keratin, high-sulfur matrix protein, B2C;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6193483; DOI=10.1093/nar/11.16.5327;
RA   Powell B.C., Sleigh M.J., Ward K.A., Rogers G.E.;
RT   "Mammalian keratin gene families: organisation of genes coding for the B2
RT   high-sulphur proteins of sheep wool.";
RL   Nucleic Acids Res. 11:5327-5346(1983).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-152, AND ACETYLATION AT ALA-2.
RX   PubMed=5289313; DOI=10.1038/newbio234148a0;
RA   Elleman T.C.;
RT   "Amino-acid sequence of a high-sulphur protein from wool.";
RL   Nature New Biol. 234:148-148(1971).
CC   -!- FUNCTION: The keratin products of mammalian epidermal derivatives such
CC       as wool and hair consist of microfibrils embedded in a rigid matrix of
CC       other proteins. The matrix proteins include the high-sulfur and high-
CC       tyrosine keratins, having molecular weights of 6-20 kDa, whereas the
CC       microfibrils contain the larger, low-sulfur keratins (40-56 kDa).
CC   -!- MISCELLANEOUS: The source of this keratin is lincoln wool.
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DR   EMBL; X02925; CAA26681.1; -; Genomic_DNA.
DR   PIR; S07349; KRSHHC.
DR   AlphaFoldDB; P02440; -.
DR   iPTMnet; P02440; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 2.
DR   Pfam; PF01500; Keratin_B2; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Keratin; Reference proteome;
KW   Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:5289313"
FT   CHAIN           2..152
FT                   /note="Keratin, high-sulfur matrix protein, B2C"
FT                   /id="PRO_0000084326"
FT   REPEAT          27..36
FT   REPEAT          37..46
FT   REPEAT          47..56
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:5289313"
SQ   SEQUENCE   152 AA;  15607 MW;  59F8AB1E56DF252C CRC64;
     MACCSTSFCG FPICSTAGTC GSSCCRSTCS QTSCCQPTSI QTSCCQPTCL QTSGCETGCG
     IGGSTGYGQV GSSGAVSSRT RWCRPDCRVE GTSLPPCCVV SCTSPSCCQL YYAQASCCRP
     SYCGQSCCRP ACCCQPTCTE PVCEPTCSQP IC