ID   KRB2D_SHEEP             Reviewed;         182 AA.
AC   P08131;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Keratin, high-sulfur matrix protein, B2D;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6193483; DOI=10.1093/nar/11.16.5327;
RA   Powell B.C., Sleigh M.J., Ward K.A., Rogers G.E.;
RT   "Mammalian keratin gene families: organisation of genes coding for the B2
RT   high-sulphur proteins of sheep wool.";
RL   Nucleic Acids Res. 11:5327-5346(1983).
CC   -!- FUNCTION: The keratin products of mammalian epidermal derivatives such
CC       as wool and hair consist of microfibrils embedded in a rigid matrix of
CC       other proteins. The matrix proteins include the high-sulfur and high-
CC       tyrosine keratins, having molecular weights of 6-20 kDa, whereas the
CC       microfibrils contain the larger, low-sulfur keratins (40-56 kDa).
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DR   EMBL; X01610; CAA25759.1; -; Genomic_DNA.
DR   PIR; S07911; KRSHHD.
DR   AlphaFoldDB; P08131; -.
DR   PRIDE; P08131; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 1.
DR   Pfam; PF01500; Keratin_B2; 1.
PE   4: Predicted;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..182
FT                   /note="Keratin, high-sulfur matrix protein, B2D"
FT                   /id="PRO_0000084327"
FT   REPEAT          27..36
FT                   /note="1"
FT   REPEAT          37..46
FT                   /note="2"
FT   REPEAT          47..56
FT                   /note="3"
FT   REPEAT          57..66
FT                   /note="4"
FT   REPEAT          67..76
FT                   /note="5"
FT   REPEAT          77..86
FT                   /note="6"
FT   REGION          27..86
FT                   /note="6 X 10 AA tandem repeats"
SQ   SEQUENCE   182 AA;  18810 MW;  253F3A4E6C412690 CRC64;
     MACCSTSFCG FPTCSTGGTC GSNFCQPTCC QTSCCQPTSI QTSCCQPTSI QTSCCQPTSI
     QTSCCQPISI QTSCCQPTCL QTSGCETGCG IGGSIGYGQV GSSGAVSSRT KWCRPDCRVE
     GTSLPPCCVV SCTSPSCCQL YYAQASCCRP SYCGQSCCRP ACCCQPTCIE PVCEPTCCEP
     TC