KRBA1_HUMAN
ID KRBA1_HUMAN Reviewed; 1030 AA.
AC A5PL33; A7E2F5; E7ENE9; Q8N4X0; Q96JG5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein KRBA1;
GN Name=KRBA1; Synonyms=KIAA1862;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP VARIANT GLU-661.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-661.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 300-1029 (ISOFORM 3), AND VARIANT GLU-661.
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-253, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101; SER-177; SER-182;
RP SER-184; SER-229; SER-253 AND SER-355, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC A5PL33-2; P49356: FNTB; NbExp=3; IntAct=EBI-14148872, EBI-602349;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A5PL33-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A5PL33-2; Sequence=VSP_027780;
CC Name=3;
CC IsoId=A5PL33-3; Sequence=VSP_027779;
CC -!- TISSUE SPECIFICITY: Expressed in brain (cerebellum).
CC {ECO:0000269|PubMed:11347906}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB47491.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB058765; BAB47491.2; ALT_INIT; mRNA.
DR EMBL; AC004897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471146; EAW80035.1; -; Genomic_DNA.
DR EMBL; BC033229; AAH33229.1; -; mRNA.
DR EMBL; BC041587; AAH41587.1; -; mRNA.
DR EMBL; BC142722; AAI42723.1; -; mRNA.
DR EMBL; BC146667; AAI46668.1; -; mRNA.
DR EMBL; BC150330; AAI50331.1; -; mRNA.
DR EMBL; BC152409; AAI52410.1; -; mRNA.
DR CCDS; CCDS75674.1; -. [A5PL33-1]
DR RefSeq; NP_001277116.1; NM_001290187.1.
DR RefSeq; NP_115923.2; NM_032534.3. [A5PL33-1]
DR AlphaFoldDB; A5PL33; -.
DR SMR; A5PL33; -.
DR BioGRID; 124155; 39.
DR IntAct; A5PL33; 26.
DR MINT; A5PL33; -.
DR STRING; 9606.ENSP00000317165; -.
DR iPTMnet; A5PL33; -.
DR PhosphoSitePlus; A5PL33; -.
DR BioMuta; KRBA1; -.
DR jPOST; A5PL33; -.
DR MassIVE; A5PL33; -.
DR PaxDb; A5PL33; -.
DR PeptideAtlas; A5PL33; -.
DR PRIDE; A5PL33; -.
DR ProteomicsDB; 17142; -.
DR ProteomicsDB; 728; -. [A5PL33-1]
DR ProteomicsDB; 729; -. [A5PL33-2]
DR ProteomicsDB; 730; -. [A5PL33-3]
DR Antibodypedia; 10441; 17 antibodies from 8 providers.
DR DNASU; 84626; -.
DR Ensembl; ENST00000319551.12; ENSP00000317165.9; ENSG00000133619.18. [A5PL33-1]
DR Ensembl; ENST00000485033.6; ENSP00000420112.2; ENSG00000133619.18. [A5PL33-3]
DR GeneID; 84626; -.
DR KEGG; hsa:84626; -.
DR UCSC; uc033api.1; human. [A5PL33-1]
DR CTD; 84626; -.
DR DisGeNET; 84626; -.
DR GeneCards; KRBA1; -.
DR HGNC; HGNC:22228; KRBA1.
DR HPA; ENSG00000133619; Tissue enhanced (heart).
DR neXtProt; NX_A5PL33; -.
DR OpenTargets; ENSG00000133619; -.
DR PharmGKB; PA162393641; -.
DR VEuPathDB; HostDB:ENSG00000133619; -.
DR eggNOG; ENOG502S92J; Eukaryota.
DR GeneTree; ENSGT00390000006211; -.
DR HOGENOM; CLU_299337_0_0_1; -.
DR InParanoid; A5PL33; -.
DR OrthoDB; 248191at2759; -.
DR PathwayCommons; A5PL33; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A5PL33; -.
DR BioGRID-ORCS; 84626; 14 hits in 285 CRISPR screens.
DR ChiTaRS; KRBA1; human.
DR GenomeRNAi; 84626; -.
DR Pharos; A5PL33; Tdark.
DR PRO; PR:A5PL33; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A5PL33; protein.
DR Bgee; ENSG00000133619; Expressed in cardiac muscle of right atrium and 149 other tissues.
DR ExpressionAtlas; A5PL33; baseline and differential.
DR Genevisible; A5PL33; HS.
DR InterPro; IPR040095; KRBA1.
DR InterPro; IPR029317; KRBA1_rpt.
DR PANTHER; PTHR22740; PTHR22740; 2.
DR Pfam; PF15287; KRBA1; 6.
DR SMART; SM01258; KRBA1; 6.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..1030
FT /note="Protein KRBA1"
FT /id="PRO_0000300111"
FT REGION 27..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 799..832
FT /evidence="ECO:0000255"
FT COMPBIAS 125..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..686
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..788
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 101
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 177
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 229
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 253
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 106
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027780"
FT VAR_SEQ 543..603
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027779"
FT VARIANT 320
FT /note="H -> R (in dbSNP:rs7791608)"
FT /id="VAR_056922"
FT VARIANT 661
FT /note="D -> E (in dbSNP:rs709065)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_068701"
SQ SEQUENCE 1030 AA; 107498 MW; D4493A910C44D41E CRC64;
MRENYETLVS VGTAELLPLS AFLSPSEPGR AVGGGSHADE GQEPAGCGDP QGGQPRHSLH
LTALVQLVKE IPEFLFGEVK GAMDSPESES RGASLDGERA SPEAAAAREP CPLRGLLSCL
PDGPTSQPHL ATTPTDSSCS SGPTGDGVQG SPLPIKTADK PWPTRKEGPG ALGGEPSPPT
HSPSRRKSHR GQERGTSEAG ISPGNSPLQG LINCLKEILV PGPRHPETSP SFLPPLPSLG
TSRLTRADLG PGSPPWAVKT EAVSGDCPLQ GLLHCLKELP EAQDRHPSPS GVGNRRLQEN
PGAWKRGSGG PGYLLTPPPH PDLGAGGLLS VKMENSWVQS PPGPASCQPG RQPLSPSATG
DTRGVPQPSW GPEAQAASAS SSPLEALEAC LKGIPPNGSS PSQLPPTSCS QNPQPGDSRS
QKPELQPHRS HSEEATREPV LPLGLQSCVR DGPSRPLAPR GTPTSFSSSS STDWDLDFGS
PVGNQGQHPG KGSPPGSSPL QGLENCLKEI PVPVLRPAWP CSSAADRGPR RAEPRNWTAD
KEGLRAEACE SARLGQGRGE APTRSLHLVS PQVFTSSCVP ACHQRGFKDP GATRPGVWRW
LPEGSAPKPS PLHCLESALR GILPVRPLRF ACVGGPSPSP SPGSSSSFSG SEGEDPRPEP
DLWKPLPQER DRLPSCKPPV PLSPCPGGTP AGSSGGSPGE DPRRTEPRYC SGLGAGTAQD
PCPVSQLEKR PRVSEASRGL ELGHGRPRVA AKTHERLLPQ GPPELPSESP PPELPPPEAA
PPVLPASSLQ PPCHCGKPLQ QELHSLGAAL AEKLDRLATA LAGLAQEVAT MRTQVNRLGR
RPQGPGPMGQ ASWMWTLPRG PRWAHGPGHR HLPYWRQKGP TRPKPKILRG QGESCRAGDL
QGLSRGTARR ARPLPPDAPP AEPPGLHCSS SQQLLSSTPS CHAAPPAHPL LAHTGGHQSP
LPPLVPAALP LQGASPPAAS ADADVPTSGV APDGIPERPK EPSSLLGGVQ RALQEELWGG
EHRDPRWGAH
