KRBA1_MOUSE
ID KRBA1_MOUSE Reviewed; 1043 AA.
AC Q6NXZ1; E9QNG7; Q69Z85; Q9JJG3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Protein KRBA1;
GN Name=Krba1; Synonyms=Kiaa1862; ORFNames=MNCb-1826;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=CD-1; TISSUE=Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NXZ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NXZ1-2; Sequence=VSP_027781, VSP_027782, VSP_027783;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32559.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB041543; BAA95028.1; -; mRNA.
DR EMBL; AK173281; BAD32559.1; ALT_INIT; mRNA.
DR EMBL; AC153815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066816; AAH66816.1; -; mRNA.
DR CCDS; CCDS20102.1; -. [Q6NXZ1-1]
DR CCDS; CCDS90043.1; -. [Q6NXZ1-2]
DR RefSeq; NP_598683.3; NM_133922.3. [Q6NXZ1-1]
DR RefSeq; XP_006506827.1; XM_006506764.3.
DR AlphaFoldDB; Q6NXZ1; -.
DR SMR; Q6NXZ1; -.
DR BioGRID; 218953; 2.
DR IntAct; Q6NXZ1; 2.
DR STRING; 10090.ENSMUSP00000110219; -.
DR iPTMnet; Q6NXZ1; -.
DR PhosphoSitePlus; Q6NXZ1; -.
DR PaxDb; Q6NXZ1; -.
DR PRIDE; Q6NXZ1; -.
DR ProteomicsDB; 263460; -. [Q6NXZ1-1]
DR ProteomicsDB; 263461; -. [Q6NXZ1-2]
DR Antibodypedia; 10441; 17 antibodies from 8 providers.
DR DNASU; 77827; -.
DR Ensembl; ENSMUST00000031815; ENSMUSP00000031815; ENSMUSG00000042810. [Q6NXZ1-2]
DR Ensembl; ENSMUST00000077093; ENSMUSP00000076345; ENSMUSG00000042810. [Q6NXZ1-1]
DR Ensembl; ENSMUST00000114571; ENSMUSP00000110218; ENSMUSG00000042810. [Q6NXZ1-1]
DR GeneID; 77827; -.
DR KEGG; mmu:77827; -.
DR UCSC; uc009bty.2; mouse. [Q6NXZ1-1]
DR UCSC; uc009bub.2; mouse. [Q6NXZ1-2]
DR CTD; 84626; -.
DR MGI; MGI:1925077; Krba1.
DR VEuPathDB; HostDB:ENSMUSG00000042810; -.
DR eggNOG; ENOG502S92J; Eukaryota.
DR GeneTree; ENSGT00390000006211; -.
DR HOGENOM; CLU_299337_0_0_1; -.
DR InParanoid; Q6NXZ1; -.
DR OMA; TCHQRGL; -.
DR OrthoDB; 248191at2759; -.
DR PhylomeDB; Q6NXZ1; -.
DR TreeFam; TF337281; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 77827; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Krba1; mouse.
DR PRO; PR:Q6NXZ1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q6NXZ1; protein.
DR Bgee; ENSMUSG00000042810; Expressed in spermatocyte and 222 other tissues.
DR ExpressionAtlas; Q6NXZ1; baseline and differential.
DR Genevisible; Q6NXZ1; MM.
DR InterPro; IPR040095; KRBA1.
DR InterPro; IPR029317; KRBA1_rpt.
DR PANTHER; PTHR22740; PTHR22740; 1.
DR Pfam; PF15287; KRBA1; 5.
DR SMART; SM01258; KRBA1; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..1043
FT /note="Protein KRBA1"
FT /id="PRO_0000300112"
FT REGION 26..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 825..858
FT /evidence="ECO:0000255"
FT COMPBIAS 120..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 99
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A5PL33"
FT MOD_RES 181
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A5PL33"
FT MOD_RES 252
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A5PL33"
FT MOD_RES 352
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A5PL33"
FT VAR_SEQ 1..11
FT /note="MRENYETLVSV -> MRSARPTQTSQLCGSRCSEFPGPASCRAELGRCPRGS
FT RGSRCSLQPEPHRKLGGPGSREAEFRHGAP (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_027781"
FT VAR_SEQ 154..155
FT /note="IG -> R (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_027782"
FT VAR_SEQ 307..372
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_027783"
FT CONFLICT 116
FT /note="N -> S (in Ref. 2; BAD32559 and 4; AAH66816)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="L -> P (in Ref. 4; AAH66816)"
FT /evidence="ECO:0000305"
FT CONFLICT 508
FT /note="I -> F (in Ref. 1; BAA95028)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1043 AA; 111257 MW; EE9C6AE5DD410FFB CRC64;
MRENYETLVS VGTSELLPLS AFLSPAEAGG ATSGESHQDK GQKPHLEHSS QGEQPQQSLH
LTALVQLVKE IPEFLFGEVK GTEDYSESGS TSLDGEQTSP EVAVVVEACP PRGLLNSLPE
SPASHPSLAT TPTGSSTSGG PPGDWAHGSP LPAIGTDDKP LSIEKEGVGA SRETSIHSTQ
SLGQSKSYLR QERGSMGTGT LPENSPLQGL INCLKEILVP RPQHRGTAPD LPPSLPGLSV
LKQTRAEVEA GSLPCPVKTE AASGDCPLQG LLNCLKEIPK APDRRPSPSG ASDLQLQEDP
GKRHSGGMRH LQTPPHPSHE AGSMLATVKV EDGWAQSPPV PASCQLSRQG YSSYSTGDNR
EVRVPRWGPM TLASRASSSP LEALEACLKG IPPGGSSPLQ SLAISWSRSP QLGDAGSQRF
ELQQQGSHSE EATREPLLPL SLQGYMREGP GVQPCGSQGT PTSFSSASSS DGDLDFRSPR
SSQGQRLGKG YLPGNSPLQG LENCLREIPI PRPQAAWPCS SAVNRGLKRT EPRNWTGDRE
GLRGEASEPP HLRQRPGEVP SRSLHQDSPQ TCTSTCHQVT TRPGTWQWPQ EETATMPSPL
HRLENSLRGI LPVRPLRFTC VTGPGPSPSP CSSSSFSSSD GEDLRPEPAF WQSPLQQKDQ
PPSCKDPVRL CPVSGASPRV NSNSCSAEDR ERTEPRDCSS LSAGRAEEKP HPPRREDGAE
RTRQPGPVTN AEGKGAAAGH PSPAPQLEEK PEPKGTEDSR DLEPGHRPPS AAARTQGKLL
SGDPPESPSK SPLPTTVLSK WSPTSLQPPC PCGRSLQQEL HNLGTALTDK LDRLAAALAG
LTQEVATMKT QMDQLRRHPR SLGPKGQGSW QLALPQRPRW VNRLGHRHLP YWRQKGPTRP
RPKILRTQAE GCKTSDRPGL SRGKGSLVPQ LPPEASLVES SRPTCSSSQQ ISSTPGGHTV
LTAHPPLEHT ACHQNPLSPS VPTSVQVPLV ASPATSADTE PPAARVAAIS IPNQPKEPDS
LLGEALSRDL WGGDHRDPRW GAH
