KRBA2_HUMAN
ID KRBA2_HUMAN Reviewed; 492 AA.
AC Q6ZNG9; Q8IYY0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=KRAB-A domain-containing protein 2;
GN Name=KRBA2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-492.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND THR-117, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- INTERACTION:
CC Q6ZNG9; Q8WUI4-6: HDAC7; NbExp=3; IntAct=EBI-13309813, EBI-12094670;
CC -!- CAUTION: It is uncertain whether Met-1 or Met-46 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AK131219; BAD18406.1; -; mRNA.
DR EMBL; BC033390; AAH33390.1; -; mRNA.
DR CCDS; CCDS11141.1; -.
DR RefSeq; NP_001291876.1; NM_001304947.1.
DR RefSeq; NP_998762.1; NM_213597.3.
DR AlphaFoldDB; Q6ZNG9; -.
DR SMR; Q6ZNG9; -.
DR BioGRID; 125885; 10.
DR IntAct; Q6ZNG9; 2.
DR STRING; 9606.ENSP00000328017; -.
DR iPTMnet; Q6ZNG9; -.
DR PhosphoSitePlus; Q6ZNG9; -.
DR BioMuta; KRBA2; -.
DR DMDM; 74710682; -.
DR MassIVE; Q6ZNG9; -.
DR PaxDb; Q6ZNG9; -.
DR PeptideAtlas; Q6ZNG9; -.
DR PRIDE; Q6ZNG9; -.
DR ProteomicsDB; 68025; -.
DR Antibodypedia; 12547; 82 antibodies from 18 providers.
DR DNASU; 124751; -.
DR Ensembl; ENST00000643221.1; ENSP00000494883.1; ENSG00000184619.8.
DR GeneID; 124751; -.
DR KEGG; hsa:124751; -.
DR UCSC; uc002glf.1; human.
DR CTD; 124751; -.
DR DisGeNET; 124751; -.
DR GeneCards; KRBA2; -.
DR HGNC; HGNC:26989; KRBA2.
DR HPA; ENSG00000184619; Tissue enriched (retina).
DR neXtProt; NX_Q6ZNG9; -.
DR OpenTargets; ENSG00000184619; -.
DR PharmGKB; PA162393680; -.
DR VEuPathDB; HostDB:ENSG00000184619; -.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT00940000163300; -.
DR InParanoid; Q6ZNG9; -.
DR OrthoDB; 1196109at2759; -.
DR PhylomeDB; Q6ZNG9; -.
DR TreeFam; TF323092; -.
DR PathwayCommons; Q6ZNG9; -.
DR SignaLink; Q6ZNG9; -.
DR BioGRID-ORCS; 124751; 10 hits in 1075 CRISPR screens.
DR ChiTaRS; KRBA2; human.
DR GenomeRNAi; 124751; -.
DR Pharos; Q6ZNG9; Tdark.
DR PRO; PR:Q6ZNG9; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6ZNG9; protein.
DR Bgee; ENSG00000184619; Expressed in apex of heart and 106 other tissues.
DR ExpressionAtlas; Q6ZNG9; baseline and differential.
DR Genevisible; Q6ZNG9; HS.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF01352; KRAB; 1.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..492
FT /note="KRAB-A domain-containing protein 2"
FT /id="PRO_0000300113"
FT DOMAIN 36..117
FT /note="KRAB"
FT DOMAIN 247..415
FT /note="Integrase catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT REGION 455..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..457
FT /evidence="ECO:0000255"
FT COMPBIAS 476..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 115
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 117
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VARIANT 435
FT /note="T -> M (in dbSNP:rs370752)"
FT /id="VAR_051087"
SQ SEQUENCE 492 AA; 56205 MW; D84C1502A38DCCAF CRC64;
MPSFLVPSLV SSPVLLKLLF SPGPKTIWSL WQQPMLFQEA TAFENMTKDW NYLEGSQKDC
YRDTMLDSYE NTVPQGSFLQ LSMMPQRAGN DPPGVSNASE MEMEISNMRE KFLMSVTKLV
ESKSYNSKVF SKEKYFQTIK EVKEAKEKGK KSSRDYRRAA KYDVISVQGT EKLIEATHGE
RDRIRYYVHK EELFDILHDT HLSIGHGGRT RMLKELQGKY GNVTKEVIVL YLTLCKQCHQ
KNPVPKRGLA PKPMTFKDID STCQVEILDM QSSADGEFKF ILYYQDHSTK FIILRPLRTK
QAHEVVSVLL DIFTILGTPS VLDSDSGVEF TNQVVHELNE LWPDLKIVSG KYHPGQSQGS
LEGASRDVKN MISTWMQSNH SCHWAKGLRF MQMVRNQAFD VSLQQSPFEA MFGYKAKFGL
YSSNLPRETV ATLQTEEELE IAEEQLENSL WIRQEERAEI GADRSDMDDD MDPTPEASEP
STSQGTSGLL CW
