KRBX5_HUMAN
ID KRBX5_HUMAN Reviewed; 126 AA.
AC Q7Z2F6; Q6ZQX1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=KRAB domain-containing protein 5 {ECO:0000305};
GN Name=KRBOX5 {ECO:0000312|HGNC:HGNC:26987}; Synonyms=ZNF720;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Urinary bladder, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q7Z2F6; Q08AM6: VAC14; NbExp=3; IntAct=EBI-2796279, EBI-2107455;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z2F6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z2F6-2; Sequence=VSP_033024, VSP_033025, VSP_033026;
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DR EMBL; AK128671; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471192; EAW52108.1; -; Genomic_DNA.
DR EMBL; BC018134; AAH18134.1; -; mRNA.
DR EMBL; BC055408; AAH55408.1; -; mRNA.
DR CCDS; CCDS45473.1; -. [Q7Z2F6-1]
DR RefSeq; NP_001124385.1; NM_001130913.1. [Q7Z2F6-1]
DR AlphaFoldDB; Q7Z2F6; -.
DR BioGRID; 125864; 3.
DR IntAct; Q7Z2F6; 6.
DR STRING; 9606.ENSP00000319222; -.
DR iPTMnet; Q7Z2F6; -.
DR PhosphoSitePlus; Q7Z2F6; -.
DR BioMuta; ZNF720; -.
DR DMDM; 74738650; -.
DR EPD; Q7Z2F6; -.
DR MassIVE; Q7Z2F6; -.
DR PaxDb; Q7Z2F6; -.
DR PeptideAtlas; Q7Z2F6; -.
DR PRIDE; Q7Z2F6; -.
DR ProteomicsDB; 68956; -. [Q7Z2F6-1]
DR ProteomicsDB; 68957; -. [Q7Z2F6-2]
DR Antibodypedia; 51739; 65 antibodies from 14 providers.
DR DNASU; 124411; -.
DR Ensembl; ENST00000316491.14; ENSP00000319222.9; ENSG00000197302.11. [Q7Z2F6-1]
DR Ensembl; ENST00000398696.3; ENSP00000443758.1; ENSG00000197302.11. [Q7Z2F6-2]
DR GeneID; 124411; -.
DR KEGG; hsa:124411; -.
DR MANE-Select; ENST00000316491.14; ENSP00000319222.9; NM_001130913.2; NP_001124385.1.
DR UCSC; uc002ecn.5; human. [Q7Z2F6-1]
DR CTD; 124411; -.
DR GeneCards; ZNF720; -.
DR HGNC; HGNC:26987; KRBOX5.
DR HPA; ENSG00000197302; Low tissue specificity.
DR neXtProt; NX_Q7Z2F6; -.
DR OpenTargets; ENSG00000197302; -.
DR VEuPathDB; HostDB:ENSG00000197302; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164574; -.
DR HOGENOM; CLU_002678_69_5_1; -.
DR InParanoid; Q7Z2F6; -.
DR OMA; EWENEVI; -.
DR OrthoDB; 1566696at2759; -.
DR PhylomeDB; Q7Z2F6; -.
DR TreeFam; TF340491; -.
DR PathwayCommons; Q7Z2F6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q7Z2F6; -.
DR BioGRID-ORCS; 124411; 349 hits in 1015 CRISPR screens.
DR ChiTaRS; ZNF720; human.
DR GenomeRNAi; 124411; -.
DR Pharos; Q7Z2F6; Tdark.
DR PRO; PR:Q7Z2F6; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q7Z2F6; protein.
DR Bgee; ENSG00000197302; Expressed in epithelial cell of pancreas and 194 other tissues.
DR ExpressionAtlas; Q7Z2F6; baseline and differential.
DR Genevisible; Q7Z2F6; HS.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..126
FT /note="KRAB domain-containing protein 5"
FT /id="PRO_0000330293"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT VAR_SEQ 1..70
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033024"
FT VAR_SEQ 71..74
FT /note="VAIQ -> MVNV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033025"
FT VAR_SEQ 123..126
FT /note="IILW -> CEGHNGYYDGHTKCKTTTYNKNLTVTGGQKHEKTQFMSVAFSKP
FT CVSVSKCQHQFLKLTFSFKGNLDNPNSDLVHVSNNHLNQLKYRTGVNVQSNISEKERFK
FT NEEVISKYDQFDGSLLKVCFTNK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033026"
SQ SEQUENCE 126 AA; 14454 MW; BF678E7D8AEF7DA3 CRC64;
MGLLTFRDVA IEFSREEWEH LDSDQKLLYG DVMLENYGNL VSLGLAVSKP DLITFLEQRK
EPWNVKSAET VAIQPDIFSH DTQGLLRKKL IEASFQKVIL DGYGSCGPQN LNLRKEWESE
GKIILW
