ID   KRCC1_HUMAN             Reviewed;         259 AA.
AC   Q9NPI7; Q3B7J7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Lysine-rich coiled-coil protein 1;
DE   AltName: Full=Cryptogenic hepatitis-binding protein 2;
GN   Name=KRCC1; Synonyms=CHBP2; ORFNames=BM-003, BM-044;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow;
RA   Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.;
RT   "A novel gene expressed in human bone marrow.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-187.
RA   Li K., Ye J., Xiao F., Chen J., Wei H.;
RT   "Expression of new gene CHBP2 associated with cryptogenic hepatitis in
RT   prokaryote cell and purification of the protein.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       Q9NPI7; A0A0C4DG62: ARL6IP4; NbExp=3; IntAct=EBI-2805442, EBI-12248874;
CC       Q9NPI7; Q6ZUT1: NKAPD1; NbExp=3; IntAct=EBI-2805442, EBI-3920396;
CC       Q9NPI7; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-2805442, EBI-12023934;
CC       Q9NPI7; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-2805442, EBI-5235340;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI07581.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=ABN71577.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF208845; AAF64259.1; -; mRNA.
DR   EMBL; AF217520; AAF67631.1; -; mRNA.
DR   EMBL; AC108479; AAY24007.1; -; Genomic_DNA.
DR   EMBL; CH471215; EAW77081.1; -; Genomic_DNA.
DR   EMBL; BC015927; AAH15927.1; -; mRNA.
DR   EMBL; BC107580; AAI07581.1; ALT_FRAME; mRNA.
DR   EMBL; EF413023; ABN71577.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS2000.1; -.
DR   RefSeq; NP_001291455.1; NM_001304526.1.
DR   RefSeq; NP_057702.1; NM_016618.2.
DR   RefSeq; XP_016859781.1; XM_017004292.1.
DR   AlphaFoldDB; Q9NPI7; -.
DR   BioGRID; 119466; 7.
DR   DIP; DIP-58940N; -.
DR   IntAct; Q9NPI7; 7.
DR   MINT; Q9NPI7; -.
DR   STRING; 9606.ENSP00000340083; -.
DR   iPTMnet; Q9NPI7; -.
DR   PhosphoSitePlus; Q9NPI7; -.
DR   BioMuta; KRCC1; -.
DR   DMDM; 74734308; -.
DR   EPD; Q9NPI7; -.
DR   jPOST; Q9NPI7; -.
DR   MassIVE; Q9NPI7; -.
DR   MaxQB; Q9NPI7; -.
DR   PaxDb; Q9NPI7; -.
DR   PeptideAtlas; Q9NPI7; -.
DR   PRIDE; Q9NPI7; -.
DR   ProteomicsDB; 82021; -.
DR   Antibodypedia; 47497; 106 antibodies from 17 providers.
DR   DNASU; 51315; -.
DR   Ensembl; ENST00000347055.4; ENSP00000340083.3; ENSG00000172086.9.
DR   Ensembl; ENST00000672766.1; ENSP00000499834.1; ENSG00000172086.9.
DR   GeneID; 51315; -.
DR   KEGG; hsa:51315; -.
DR   MANE-Select; ENST00000347055.4; ENSP00000340083.3; NM_016618.3; NP_057702.1.
DR   UCSC; uc002sso.1; human.
DR   CTD; 51315; -.
DR   GeneCards; KRCC1; -.
DR   HGNC; HGNC:28039; KRCC1.
DR   HPA; ENSG00000172086; Low tissue specificity.
DR   neXtProt; NX_Q9NPI7; -.
DR   OpenTargets; ENSG00000172086; -.
DR   PharmGKB; PA162393681; -.
DR   VEuPathDB; HostDB:ENSG00000172086; -.
DR   eggNOG; ENOG502RTYF; Eukaryota.
DR   GeneTree; ENSGT00940000162565; -.
DR   HOGENOM; CLU_032533_0_0_1; -.
DR   InParanoid; Q9NPI7; -.
DR   OMA; KMRGDYL; -.
DR   OrthoDB; 1288916at2759; -.
DR   PhylomeDB; Q9NPI7; -.
DR   PathwayCommons; Q9NPI7; -.
DR   SignaLink; Q9NPI7; -.
DR   BioGRID-ORCS; 51315; 13 hits in 1063 CRISPR screens.
DR   ChiTaRS; KRCC1; human.
DR   GenomeRNAi; 51315; -.
DR   Pharos; Q9NPI7; Tdark.
DR   PRO; PR:Q9NPI7; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q9NPI7; protein.
DR   Bgee; ENSG00000172086; Expressed in colonic mucosa and 202 other tissues.
DR   ExpressionAtlas; Q9NPI7; baseline and differential.
DR   Genevisible; Q9NPI7; HS.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..259
FT                   /note="Lysine-rich coiled-coil protein 1"
FT                   /id="PRO_0000306396"
FT   REGION          141..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          169..249
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        162..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  30980 MW;  1FD963D642683F01 CRC64;
     MKHSKKTYDS FQDELEDYIK VQKARGLEPK TCFRKMKGDY LETCGYKGEV NSRPTYRMFD
     QRLPSETIQT YPRSCNIPQT VENRLPQWLP AHDSRLRLDS LSYCQFTRDC FSEKPVPLNF
     NQQEYICGSH GVEHRVYKHF SSDNSTSTHQ ASHKQIHQKR KRHPEEGREK SEEERSKHKR
     KKSCEEIDLD KHKSIQRKKT EVEIETVHVS TEKLKNRKEK KSRDVVSKKE ERKRTKKKKE
     QGQERTEEEM LWDQSILGF