ARC2B_ARATH
ID ARC2B_ARATH Reviewed; 374 AA.
AC F4IVU1;
DT 29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Actin-related protein 2/3 complex subunit 2B;
DE AltName: Full=Actin-related protein C2B;
DE AltName: Full=Arp2/3 complex 34 kDa subunit;
DE Short=p34-ARC;
GN Name=ARPC2B; OrderedLocusNames=At2g33385; ORFNames=F4P9.42;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=15086808; DOI=10.1111/j.1365-313x.2004.02065.x;
RA El-Din El-Assal S., Le J., Basu D., Mallery E.L., Szymanski D.B.;
RT "DISTORTED2 encodes an ARPC2 subunit of the putative Arabidopsis ARP2/3
RT complex.";
RL Plant J. 38:526-538(2004).
RN [4]
RP REVIEW.
RX PubMed=15653407; DOI=10.1016/j.pbi.2004.11.004;
RA Szymanski D.B.;
RT "Breaking the WAVE complex: the point of Arabidopsis trichomes.";
RL Curr. Opin. Plant Biol. 8:103-112(2005).
CC -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
CC which is involved in regulation of actin polymerization and together
CC with an activating nucleation-promoting factor (NPF) mediates the
CC formation of branched actin networks. Seems to contact the mother actin
CC filament (By similarity). Arp2/3 complex plays a critical role in the
CC control of cell morphogenesis via the modulation of cell polarity
CC development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Arp2/3 complex composed of ARP2, ARP3,
CC ARPC1/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and
CC ARPC5/p16-ARC. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC projection {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=F4IVU1-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed at low levels in all tissues with a
CC relatively highest expression in inflorescences.
CC {ECO:0000269|PubMed:15086808}.
CC -!- SIMILARITY: Belongs to the ARPC2 family. {ECO:0000305}.
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DR EMBL; AC002332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; AEC08828.1; -; Genomic_DNA.
DR RefSeq; NP_001189666.1; NM_001202737.2. [F4IVU1-1]
DR AlphaFoldDB; F4IVU1; -.
DR SMR; F4IVU1; -.
DR STRING; 3702.AT2G33385.2; -.
DR PaxDb; F4IVU1; -.
DR EnsemblPlants; AT2G33385.2; AT2G33385.2; AT2G33385. [F4IVU1-1]
DR GeneID; 817902; -.
DR Gramene; AT2G33385.2; AT2G33385.2; AT2G33385. [F4IVU1-1]
DR KEGG; ath:AT2G33385; -.
DR Araport; AT2G33385; -.
DR TAIR; locus:504956012; AT2G33385.
DR eggNOG; KOG2826; Eukaryota.
DR InParanoid; F4IVU1; -.
DR OrthoDB; 1345377at2759; -.
DR PRO; PR:F4IVU1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IVU1; baseline and differential.
DR GO; GO:0005885; C:Arp2/3 protein complex; IBA:GO_Central.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; TAS:TAIR.
DR GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR Gene3D; 3.30.1460.20; -; 2.
DR InterPro; IPR007188; ARPC2.
DR InterPro; IPR034666; ARPC2/4.
DR PANTHER; PTHR12058; PTHR12058; 1.
DR Pfam; PF04045; P34-Arc; 1.
DR SUPFAM; SSF69645; SSF69645; 2.
PE 2: Evidence at transcript level;
KW Actin-binding; Alternative splicing; Cell projection; Cytoplasm;
KW Cytoskeleton; Reference proteome.
FT CHAIN 1..374
FT /note="Actin-related protein 2/3 complex subunit 2B"
FT /id="PRO_0000422529"
SQ SEQUENCE 374 AA; 43171 MW; 598853D7ABEF78A9 CRC64;
MAYLERASPT LKETLLKIYR AEKPIEVDQH FHEFGSIEYH IKYSVSDPNI VHVSTSTLLE
TQGAVTLKEI SSYTYEVIKN IGVGVIDIVD PPRLGFQLTL GLNLDNIPRG KEAIKIITRI
SELQAIILSS QLKEMLRSLN FQDDSRSINN MPIRIVYHPS EPFYVFKQPE KITAVFPMNF
KDNSDVVIAT SFFQELVEVG SQKDMGKAPQ CSWSPIPPLQ LRGEPVQDLT TNSGFVSFDI
TSRHIEGKRL DKTVWNLLNF YACAKYHIKC SRGYIQRRMR KRMETLVKLL NNTSLEEEAA
QNENGRCKYV KEFVKVPKGK LMMKQRCKEM TRRVKISKFR IKINGCARFR FNQRWISLPK
FSSKPSDKSY TKLD
