ID   KRE28_KLULA             Reviewed;         351 AA.
AC   Q6CV05;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Spindle pole body component KRE28;
GN   Name=KRE28; OrderedLocusNames=KLLA0C00891g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for kinetochore binding by a discrete subset of
CC       kMAPs and motors. Involved in kinetochore-microtubule binding and the
CC       spindle assembly checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, spindle pole body {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic
CC       side {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
CC       Note=Localizes to the nuclear side of the spindle pole body.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRE28 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01085.1; -; Genomic_DNA.
DR   RefSeq; XP_452234.1; XM_452234.1.
DR   AlphaFoldDB; Q6CV05; -.
DR   SMR; Q6CV05; -.
DR   STRING; 28985.XP_452234.1; -.
DR   EnsemblFungi; CAH01085; CAH01085; KLLA0_C00891g.
DR   GeneID; 2892376; -.
DR   KEGG; kla:KLLA0_C00891g; -.
DR   eggNOG; ENOG502S19U; Eukaryota.
DR   HOGENOM; CLU_062083_0_0_1; -.
DR   InParanoid; Q6CV05; -.
DR   OMA; LADECHT; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031361; Kre28.
DR   Pfam; PF17097; Kre28; 1.
PE   3: Inferred from homology;
KW   Centromere; Chromosome; Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore;
KW   Membrane; Nucleus; Reference proteome.
FT   CHAIN           1..351
FT                   /note="Spindle pole body component KRE28"
FT                   /id="PRO_0000408562"
FT   COILED          124..153
FT                   /evidence="ECO:0000255"
FT   COILED          208..234
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   351 AA;  41058 MW;  6E18F22203883A52 CRC64;
     MTHYHSEYYS EVEKFEYQVT HVTEQILQEQ DRLRGSTLHE YNQTILQLVS DYEMFNSNGQ
     CDPSEINLPL EKLESWTNSL KQIHLELESI DNFLRYAIPS DQTILNLSKF NESKYETLQA
     EVSELRDINV VQLQKEIESL QQQITTKSDE NLLISEKIKE SCLEASQDID QCWKLLEQLE
     AYENANPSTE VITTTDPAFS TYNQWKWNQL AESELKHINQ QLITLRATKE KLDKVFSKRS
     ELETSPKSIE TFTSYQLLSQ LWRSKFIRQL LPDIANLEVY PQSGKLKFEV GIMQVIMQIE
     SGIIKSVSLF SYELSYDRIE TIKEDILGRI EHQKSLFKVL VVITDYIVNS L