KRE28_VANPO
ID KRE28_VANPO Reviewed; 378 AA.
AC A7TFD7;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Spindle pole body component KRE28;
GN Name=KRE28; ORFNames=Kpol_2002p21;
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC Y-8283 / UCD 57-17;
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- FUNCTION: Required for kinetochore binding by a discrete subset of
CC kMAPs and motors. Involved in kinetochore-microtubule binding and the
CC spindle assembly checkpoint (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, spindle pole body {ECO:0000250}. Nucleus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic
CC side {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
CC Note=Localizes to the nuclear side of the spindle pole body.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KRE28 family. {ECO:0000305}.
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DR EMBL; DS480383; EDO18951.1; -; Genomic_DNA.
DR RefSeq; XP_001646809.1; XM_001646759.1.
DR AlphaFoldDB; A7TFD7; -.
DR SMR; A7TFD7; -.
DR STRING; 436907.A7TFD7; -.
DR EnsemblFungi; EDO18951; EDO18951; Kpol_2002p21.
DR GeneID; 5547274; -.
DR KEGG; vpo:Kpol_2002p21; -.
DR eggNOG; ENOG502S19U; Eukaryota.
DR HOGENOM; CLU_062083_0_0_1; -.
DR InParanoid; A7TFD7; -.
DR OMA; LADECHT; -.
DR OrthoDB; 1204570at2759; -.
DR PhylomeDB; A7TFD7; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR InterPro; IPR031361; Kre28.
DR Pfam; PF17097; Kre28; 1.
PE 3: Inferred from homology;
KW Centromere; Chromosome; Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore;
KW Membrane; Nucleus; Reference proteome.
FT CHAIN 1..378
FT /note="Spindle pole body component KRE28"
FT /id="PRO_0000408564"
FT COILED 1..32
FT /evidence="ECO:0000255"
FT COILED 130..172
FT /evidence="ECO:0000255"
FT COILED 224..277
FT /evidence="ECO:0000255"
SQ SEQUENCE 378 AA; 43331 MW; 4A3758783D98DACB CRC64;
METQAVKTIR DELRELENTV AQASDMVLSE QDHRNASAIR EMTQSVIAMS KENSLISVSN
EIDYNEEIGN LAIDPSLIDE KIKQSNNFVE LLKLTHLEQE ALDYFLRYTI SSTNTLELES
TSDPKFVSLE NEVTELENKT LTEHRDKIQE AKKDISDKSK DLANKQDQIN ELCLGAANSV
DECWKMLNEL EDIHSQRDND VKETLSQDTT TTSDLIEETY KEWSSLQTSL TELNNSKDEL
DQLIAFKNEK HKDNDSTKIR NANIKNKTIT ENVKMLKLLI NFWESNFIVP GSKKSKLSNL
EVYPQTKKFQ FKCAEQYTVI IQLNQNGGSI KSIEIFENDG KSVQENKNLS SLILNKYKNP
LSSYPIFQVI NDIVEELK