KRE9_YEAST
ID KRE9_YEAST Reviewed; 276 AA.
AC P39005; D6VW14;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Cell wall synthesis protein KRE9 {ECO:0000305};
DE AltName: Full=Killer toxin resistant protein 9 {ECO:0000303|PubMed:8462845};
DE Flags: Precursor;
GN Name=KRE9 {ECO:0000303|PubMed:8462845};
GN OrderedLocusNames=YJL174W {ECO:0000312|SGD:S000003710}; ORFNames=J0504;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=8413233; DOI=10.1128/mcb.13.10.6346-6356.1993;
RA Brown J.L., Bussey H.;
RT "The yeast KRE9 gene encodes an O glycoprotein involved in cell surface
RT beta-glucan assembly.";
RL Mol. Cell. Biol. 13:6346-6356(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Loehning C., Mueller C., Freidel K., Ciriacy M.;
RL Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP FUNCTION.
RX PubMed=8462845; DOI=10.1093/genetics/133.4.837;
RA Brown J.L., Kossaczka Z., Jiang B., Bussey H.;
RT "A mutational analysis of killer toxin resistance in Saccharomyces
RT cerevisiae identifies new genes involved in cell wall (1-->6)-beta-glucan
RT synthesis.";
RL Genetics 133:837-849(1993).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=29897761; DOI=10.1021/acs.jproteome.8b00032;
RA He C., Jia C., Zhang Y., Xu P.;
RT "Enrichment-based proteogenomics identifies microproteins, missing
RT proteins, and novel smORFs in Saccharomyces cerevisiae.";
RL J. Proteome Res. 17:2335-2344(2018).
CC -!- FUNCTION: Involved in cell wall beta(1->6) glucan synthesis.
CC {ECO:0000269|PubMed:8413233, ECO:0000269|PubMed:8462845}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305}.
CC -!- PTM: O-glycosylated.
CC -!- SIMILARITY: Belongs to the KRE9/KNH1 family. {ECO:0000305}.
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DR EMBL; L22517; AAC37363.1; -; Genomic_DNA.
DR EMBL; X56792; CAA40111.1; -; Genomic_DNA.
DR EMBL; Z49449; CAA89469.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08630.1; -; Genomic_DNA.
DR PIR; S23891; S23891.
DR RefSeq; NP_012361.1; NM_001181607.1.
DR AlphaFoldDB; P39005; -.
DR BioGRID; 33586; 313.
DR DIP; DIP-5609N; -.
DR IntAct; P39005; 2.
DR MINT; P39005; -.
DR STRING; 4932.YJL174W; -.
DR MaxQB; P39005; -.
DR PaxDb; P39005; -.
DR PRIDE; P39005; -.
DR EnsemblFungi; YJL174W_mRNA; YJL174W; YJL174W.
DR GeneID; 853265; -.
DR KEGG; sce:YJL174W; -.
DR SGD; S000003710; KRE9.
DR VEuPathDB; FungiDB:YJL174W; -.
DR eggNOG; ENOG502S28F; Eukaryota.
DR GeneTree; ENSGT00940000176711; -.
DR HOGENOM; CLU_063732_1_0_1; -.
DR InParanoid; P39005; -.
DR OMA; QMQPGST; -.
DR BioCyc; YEAST:G3O-31610-MON; -.
DR PRO; PR:P39005; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P39005; protein.
DR GO; GO:0005576; C:extracellular region; IDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0006078; P:(1->6)-beta-D-glucan biosynthetic process; IBA:GO_Central.
DR GO; GO:0006077; P:(1->6)-beta-D-glucan metabolic process; IMP:SGD.
DR GO; GO:0042546; P:cell wall biogenesis; IEA:InterPro.
DR GO; GO:0031505; P:fungal-type cell wall organization; IMP:SGD.
DR InterPro; IPR045328; Kre9/Knh1.
DR InterPro; IPR018466; Kre9/Knh1-like_N.
DR InterPro; IPR008659; Kre9/Knh1_C.
DR PANTHER; PTHR28154; PTHR28154; 1.
DR Pfam; PF10342; GPI-anchored; 1.
DR Pfam; PF05390; KRE9; 1.
PE 1: Evidence at protein level;
KW Cell wall; Cell wall biogenesis/degradation; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..276
FT /note="Cell wall synthesis protein KRE9"
FT /id="PRO_0000016849"
SQ SEQUENCE 276 AA; 29989 MW; 0427F2432E18D93F CRC64;
MRLQRNSIIC ALVFLVSFVL GDVNIVSPSS KATFSPSGGT VSVPVEWMDN GAYPSLSKIS
TFTFSLCTGP NNNIDCVAVL ASKITPSELT QDDKVYSYTA EFASTLTGNG QYYIQVFAQV
DGQGYTIHYT PRFQLTSMGG VTAYTYSATT EPTPQTSIQT TTTNNAQATT IDSRSFTVPY
TKQTGTSRFA PMQMQPNTKV TATTWTRKFA TSAVTYYSTF GSLPEQATTI TPGWSYTISS
GVNYATPASM PSDNGGWYKP SKRLSLSARK INMRKV
