ID   KREG1_CAEEL             Reviewed;          83 AA.
AC   Q20689;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Protein kreg-1 {ECO:0000312|WormBase:F53A9.2};
GN   Name=kreg-1 {ECO:0000312|WormBase:F53A9.2};
GN   ORFNames=F53A9.2 {ECO:0000312|WormBase:F53A9.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, TISSUE SPECIFICITY, INDUCTION BY COPPER IONS, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=23437011; DOI=10.1371/journal.pgen.1003315;
RA   Hattori A., Mizuno T., Akamatsu M., Hisamoto N., Matsumoto K.;
RT   "The Caenorhabditis elegans JNK signaling pathway activates expression of
RT   stress response genes by derepressing the Fos/HDAC repressor complex.";
RL   PLoS Genet. 9:E1003315-E1003315(2013).
CC   -!- FUNCTION: Plays a role in the stress response to heavy metals such as
CC       copper, probably in a fos-1/kgb-1-dependent manner.
CC       {ECO:0000269|PubMed:23437011}.
CC   -!- TISSUE SPECIFICITY: Weakly expressed in the intestine, but expression
CC       is up-regulated in response to Cu(2+). {ECO:0000269|PubMed:23437011}.
CC   -!- INDUCTION: By heavy metal stress conditions, in response to Cu(2+).
CC       {ECO:0000269|PubMed:23437011}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in partial
CC       sensitivity to Cu(2+) ions with only 60% of animals reaching adulthood
CC       4 days after egg laying. {ECO:0000269|PubMed:23437011}.
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DR   EMBL; BX284606; CCD68801.1; -; Genomic_DNA.
DR   PIR; T16435; T16435.
DR   RefSeq; NP_509473.1; NM_077072.3.
DR   AlphaFoldDB; Q20689; -.
DR   DIP; DIP-25911N; -.
DR   IntAct; Q20689; 1.
DR   STRING; 6239.F53A9.2; -.
DR   PaxDb; Q20689; -.
DR   EnsemblMetazoa; F53A9.2.1; F53A9.2.1; WBGene00018725.
DR   GeneID; 186143; -.
DR   KEGG; cel:CELE_F53A9.2; -.
DR   UCSC; F53A9.2; c. elegans.
DR   CTD; 186143; -.
DR   WormBase; F53A9.2; CE02762; WBGene00018725; kreg-1.
DR   eggNOG; ENOG502TIFU; Eukaryota.
DR   GeneTree; ENSGT00970000196062; -.
DR   HOGENOM; CLU_2560486_0_0_1; -.
DR   InParanoid; Q20689; -.
DR   OMA; HVHSEGH; -.
DR   PRO; PR:Q20689; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00018725; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:1990169; P:stress response to copper ion; IMP:WormBase.
DR   InterPro; IPR040232; Kreg-1.
DR   PANTHER; PTHR31117; PTHR31117; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Stress response.
FT   CHAIN           1..83
FT                   /note="Protein kreg-1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434948"
FT   REGION          62..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   83 AA;  9300 MW;  DFF31DFB5CC81F18 CRC64;
     MSYYGNGGYN PYGAYGNVPP PVYGTPGLAP PTVHVHTDGG HHHGHHHHHH SFLHELGHAL
     TGHHHHHHGH HFGHHHHHHH GHH