ID   ARC2_PHAVU              Reviewed;         265 AA.
AC   P19330;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Arcelin-2;
DE   Flags: Precursor;
GN   Name=ARC2;
OS   Phaseolus vulgaris (Kidney bean) (French bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX   NCBI_TaxID=3885;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1691123; DOI=10.1016/0378-1119(90)90276-w;
RA   John M.E., Long C.M.;
RT   "Sequence analysis of arcelin 2, a lectin-like plant protein.";
RL   Gene 86:171-176(1990).
CC   -!- FUNCTION: Seed storage. This carbohydrate-binding lectin has toxic
CC       effects on bean bruchid pests. Antibiosis properties of legume lectins
CC       are proposed to be due to the lysis of epithelial cells of the
CC       intestine by binding to the carbohydrate moieties of these proteins.
CC   -!- SIMILARITY: Belongs to the leguminous lectin family. {ECO:0000305}.
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DR   EMBL; M28470; AAA33754.1; -; mRNA.
DR   PIR; JQ0435; JQ0435.
DR   AlphaFoldDB; P19330; -.
DR   SMR; P19330; -.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   CDD; cd06899; lectin_legume_LecRK_Arcelin_ConA; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR016363; L-lectin.
DR   InterPro; IPR000985; Lectin_LegA_CS.
DR   InterPro; IPR019825; Lectin_legB_Mn/Ca_BS.
DR   InterPro; IPR001220; Legume_lectin_dom.
DR   Pfam; PF00139; Lectin_legB; 1.
DR   PIRSF; PIRSF002690; L-type_lectin_plant; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS00308; LECTIN_LEGUME_ALPHA; 1.
DR   PROSITE; PS00307; LECTIN_LEGUME_BETA; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Lectin; Plant defense; Seed storage protein;
KW   Signal; Storage protein; Toxin.
FT   SIGNAL          1..21
FT   CHAIN           22..265
FT                   /note="Arcelin-2"
FT                   /id="PRO_0000017637"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        165..201
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   265 AA;  29275 MW;  1E9FBFC0F1C65388 CRC64;
     MASSNLLTLA LFLVLLTHAN SSNDASFNVE TFNKTNLILQ GDATVSSEGH LLLTNVKGNE
     EDSMGRAFYS APIQINDRTI DNLASFSTNF TFRINAKNNE NSAYGLAFAL VPVGSRPKLK
     GRYLGLFNTA NYDRDAHTVA VVFDTVSNRI EIDVNSIRPI ATESCNFGHN NGEKAEVRIT
     YYSPKNDLRV SLLYPSSEEK CHVSATVPLE KEVEDWVSVG FSATSGSKKE TTETHNVLSW
     SFSSNFINFE GKKSERSNIL LNKIL