ID   ARC3B_XENLA             Reviewed;         178 AA.
AC   Q7T0U5;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Actin-related protein 2/3 complex subunit 3-B;
GN   Name=arpc3-b; ORFNames=XELAEV_18007840mg {ECO:0000312|EMBL:OCU02081.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J;
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA   Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA   Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA   Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA   Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA   Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA   Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA   Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA   Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA   Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA   Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that
CC       mediates actin polymerization upon stimulation by nucleation-promoting
CC       factor (NPF). The Arp2/3 complex mediates the formation of branched
CC       actin networks in the cytoplasm, providing the force for cell motility.
CC       In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3
CC       complex also promotes actin polymerization in the nucleus, thereby
CC       regulating gene transcription and repair of damaged DNA (By
CC       similarity). The Arp2/3 complex promotes homologous recombination (HR)
CC       repair in response to DNA damage by promoting nuclear actin
CC       polymerization, leading to drive motility of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250|UniProtKB:A1DPK7,
CC       ECO:0000250|UniProtKB:O15145}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex composed of actr2/arp2,
CC       actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
CC       {ECO:0000250|UniProtKB:A1DPK7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:A1DPK7}. Cell projection
CC       {ECO:0000250|UniProtKB:A1DPK7}. Nucleus {ECO:0000250|UniProtKB:A1DPK7}.
CC   -!- SIMILARITY: Belongs to the ARPC3 family. {ECO:0000305}.
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DR   EMBL; CM004466; OCU02081.1; -; Genomic_DNA.
DR   EMBL; BC056034; AAH56034.1; -; mRNA.
DR   RefSeq; NP_001080054.1; NM_001086585.1.
DR   AlphaFoldDB; Q7T0U5; -.
DR   SMR; Q7T0U5; -.
DR   IntAct; Q7T0U5; 1.
DR   MINT; Q7T0U5; -.
DR   STRING; 8355.Q7T0U5; -.
DR   DNASU; 379746; -.
DR   GeneID; 379746; -.
DR   KEGG; xla:379746; -.
DR   CTD; 379746; -.
DR   Xenbase; XB-GENE-494119; arpc3.L.
DR   OMA; SEIEEFH; -.
DR   OrthoDB; 1451115at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 379746; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005885; C:Arp2/3 protein complex; ISS:UniProtKB.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 1.10.1760.10; -; 1.
DR   InterPro; IPR007204; ARPC3.
DR   InterPro; IPR036753; ARPC3_sf.
DR   PANTHER; PTHR12391; PTHR12391; 1.
DR   Pfam; PF04062; P21-Arc; 1.
DR   PIRSF; PIRSF016315; ARP2/3_P21-Arc; 1.
DR   SUPFAM; SSF69060; SSF69060; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell projection; Cytoplasm; Cytoskeleton; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..178
FT                   /note="Actin-related protein 2/3 complex subunit 3-B"
FT                   /id="PRO_0000445562"
SQ   SEQUENCE   178 AA;  20598 MW;  64932D75D8BA6C4E CRC64;
     MPAYHSILME SDTKLIGNMA MLPIRSQFKG PAPRETKDTD IIDEAIYYFK ANVFFKNYEI
     KNEADRTLIY ITLYISECLK KLQKCNSKGQ GEKEMYTLGI TNFPIPGEPG FPLNAMYVKP
     SNKQEDEVMR AYLQQLRQET GLRLCDKVFD PQTDKPSKWW ICFVKKQFMN KSLSGPGQ