KRH2_DROME
ID KRH2_DROME Reviewed; 276 AA.
AC Q9V447; C0PV57; E1JHA1;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Krueppel homolog 2;
DE AltName: Full=Protein Kr-h2;
GN Name=Kr-h2; ORFNames=CG9159;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=Canton-S;
RX PubMed=10816971; DOI=10.1017/s0016672399004437;
RA Benevolenskaya E.V., Frolov M.V., Birchler J.A.;
RT "Kruppel homolog (Kr h) is a dosage-dependent modifier of gene expression
RT in Drosophila.";
RL Genet. Res. 75:137-142(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Sandler J., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Member of the dosage-dependent hierarchy effective upon white
CC gene expression. {ECO:0000269|PubMed:10816971}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PER33/POM33 family. {ECO:0000305}.
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DR EMBL; AF148686; AAD45272.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF52341.1; -; Genomic_DNA.
DR EMBL; AE014134; ACZ94185.1; -; Genomic_DNA.
DR EMBL; AY118281; AAM48310.1; -; mRNA.
DR EMBL; BT072913; ACN81334.1; -; mRNA.
DR RefSeq; NP_001162894.1; NM_001169423.1.
DR RefSeq; NP_001285663.1; NM_001298734.1.
DR RefSeq; NP_523490.1; NM_078766.3.
DR AlphaFoldDB; Q9V447; -.
DR BioGRID; 60023; 64.
DR DIP; DIP-20347N; -.
DR IntAct; Q9V447; 9.
DR STRING; 7227.FBpp0078823; -.
DR iPTMnet; Q9V447; -.
DR PaxDb; Q9V447; -.
DR PRIDE; Q9V447; -.
DR DNASU; 33859; -.
DR EnsemblMetazoa; FBtr0079192; FBpp0078823; FBgn0266449.
DR EnsemblMetazoa; FBtr0302212; FBpp0291422; FBgn0266449.
DR EnsemblMetazoa; FBtr0343126; FBpp0309826; FBgn0266449.
DR GeneID; 33859; -.
DR KEGG; dme:Dmel_CG9159; -.
DR CTD; 33859; -.
DR FlyBase; FBgn0266449; Kr-h2.
DR VEuPathDB; VectorBase:FBgn0266449; -.
DR eggNOG; KOG4002; Eukaryota.
DR HOGENOM; CLU_071391_0_0_1; -.
DR InParanoid; Q9V447; -.
DR OMA; FFSIRPT; -.
DR OrthoDB; 1360050at2759; -.
DR PhylomeDB; Q9V447; -.
DR BioGRID-ORCS; 33859; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33859; -.
DR PRO; PR:Q9V447; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0266449; Expressed in spermathecum and 24 other tissues.
DR ExpressionAtlas; Q9V447; baseline and differential.
DR Genevisible; Q9V447; DM.
DR GO; GO:0012505; C:endomembrane system; HDA:FlyBase.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR GO; GO:0061024; P:membrane organization; IBA:GO_Central.
DR InterPro; IPR005344; TMEM33/Pom33.
DR Pfam; PF03661; TMEM33_Pom33; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..276
FT /note="Krueppel homolog 2"
FT /id="PRO_0000220903"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 22
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 276 AA; 31215 MW; 1430CC39A1429140 CRC64;
MSAPTDQPPR SEGAQTNSSE RSSQQQEQPQ QSQSQNVPAK LLQHFQTNRI DSALWALRLL
VIFFTVSYVL PIFTSQQSAF SKVMLANAAI SALRLHQRLP AFAFSREFLA RLFAEDSCHY
MMYSLIFFNI RPSLLVLIPV LLYSVLHASS YSLKLLDLIG QNSWWGARFI ISIVEFQAAN
ILKATAFCEI FIMPYAIVLA FMNHAGLMTP VIYYHYLVMR YSSRRNPYPR NAFAELRITF
EALAARSPPA FAKIIRGGIG FVNRLAPQLQ PAAAQE
