KRI1_DROME
ID KRI1_DROME Reviewed; 855 AA.
AC Q9VTU0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein KRI1 homolog;
GN ORFNames=CG5645;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95; SER-97; SER-98; SER-137
RP AND SER-138, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the KRI1 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF49956.1; -; Genomic_DNA.
DR EMBL; AY061053; AAL28601.1; -; mRNA.
DR RefSeq; NP_648550.1; NM_140293.3.
DR AlphaFoldDB; Q9VTU0; -.
DR BioGRID; 64737; 13.
DR IntAct; Q9VTU0; 10.
DR STRING; 7227.FBpp0075756; -.
DR iPTMnet; Q9VTU0; -.
DR PaxDb; Q9VTU0; -.
DR PRIDE; Q9VTU0; -.
DR DNASU; 39382; -.
DR EnsemblMetazoa; FBtr0076024; FBpp0075756; FBgn0036254.
DR GeneID; 39382; -.
DR KEGG; dme:Dmel_CG5645; -.
DR UCSC; CG5645-RA; d. melanogaster.
DR FlyBase; FBgn0036254; CG5645.
DR VEuPathDB; VectorBase:FBgn0036254; -.
DR eggNOG; KOG2409; Eukaryota.
DR GeneTree; ENSGT00390000005605; -.
DR HOGENOM; CLU_009647_0_0_1; -.
DR InParanoid; Q9VTU0; -.
DR OMA; QWRKETF; -.
DR OrthoDB; 572360at2759; -.
DR PhylomeDB; Q9VTU0; -.
DR BioGRID-ORCS; 39382; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39382; -.
DR PRO; PR:Q9VTU0; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036254; Expressed in ovary and 33 other tissues.
DR Genevisible; Q9VTU0; DM.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR InterPro; IPR018034; Kri1.
DR InterPro; IPR024626; Kri1-like_C.
DR PANTHER; PTHR14490; PTHR14490; 1.
DR Pfam; PF05178; Kri1; 1.
DR Pfam; PF12936; Kri1_C; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..855
FT /note="Protein KRI1 homolog"
FT /id="PRO_0000372654"
FT REGION 47..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 307..362
FT /evidence="ECO:0000255"
FT COMPBIAS 85..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 95
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 98
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
SQ SEQUENCE 855 AA; 98722 MW; C01BCC91244E5B07 CRC64;
MNNNLFEGSD DDGEDLQLST NKDYAKTYNI LRKKELLQKY KDRGLDVSES EFDSDSSSSE
EDEVDPKFDQ DFFKTLSSLK SKDPCIYDKG TKFFSESSGD EDDKDGEAPK KKKKAKPVTL
KDYERKVILE HNGKFESSDE EQQEKEHEEL QRAQSPSAVE EERRLKAEFR KVMNKEDDSE
DEEFGGIFKK RSKTKEQTAA EEADFAKWLA GKQAEIQETD KKQLEPLKQY WSSNKLTQGE
SFLRDYILNK GYANTDESAI PTYDEIVGEA APLSEDEQEL EKQAEFEHKY NFRFEEPDAD
FIKRYPRTIE QSLRRTDDKR KEKRKELKER KDQEKQQKMK ELELVKEMKR KEIDEKIRKL
KAVTGNDELG FRDEELEEDF DPAAHDRRMQ ELFDDEYYNV DEGEEKPECP SDIDELVLED
WDNYDPRQHA NGGGEDYEGH CEDDDFNMDC DYDPSTAKEQ LQQELIENTR GRKGRKGRRN
RFMEMIQAEK PAFNPEDEKT YSEYIDEYYQ MDCEDIIGDQ PCRFKYVETT PNDFGLTIEE
ILLAKNKELN QWASLKKAVQ NRPEHVEKKE QRLYKMKAKN EDLKRKIFKS LYGEGSDDEE
QPAEEKPEVT PAEATAPAEN GQVSTEGLSK SKRKRLKRKA AAAAASAPKV LKEESDSKDP
KEADGSTEDV QAESSKKKVD TPSKKGKDDA NQETKNSPQS TEKTKNNNAL KNNKKEPKNV
QNGFQKPQNQ ANKSAKTKSN QPFKTTESAP AKAEKSNGNN PFNKPQSKSQ QRQELPPIHK
NQGGNKKGPR NANGTNPFKK SNQKPSAPFP AKKTNNFKAK NKQNNNSGIT DDRLKAYGIN
PRKFHKREKY GKKDN
