ID   KRIP1_HUMAN             Reviewed;         134 AA.
AC   Q107X0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Putative protein KRIP1;
DE   AltName: Full=Kallikrein-related in prostate protein 1;
DE   AltName: Full=Kallikrein-related mRNA protein;
DE            Short=KARMA;
GN   Name=KLKP1; Synonyms=KLK31P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16541416; DOI=10.1002/pros.20382;
RA   Lu W., Zhou D., Glusman G., Utleg A.G., White J.T., Nelson P.S.,
RA   Vasicek T.J., Hood L., Lin B.;
RT   "KLK31P is a novel androgen regulated and transcribed pseudogene of
RT   kallikreins that is expressed at lower levels in prostate cancer cells than
RT   in normal prostate cells.";
RL   Prostate 66:936-944(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, INDUCTION,
RP   AND TISSUE SPECIFICITY.
RX   PubMed=18196551; DOI=10.1002/pros.20685;
RA   Kaushal A., Myers S.A., Dong Y., Lai J., Tan O.L., Bui L.T., Hunt M.L.,
RA   Digby M.R., Samaratunga H., Gardiner R.A., Clements J.A., Hooper J.D.;
RT   "A novel transcript from the KLKP1 gene is androgen regulated, down-
RT   regulated during prostate cancer progression and encodes the first non-
RT   serine protease identified from the human kallikrein gene locus.";
RL   Prostate 68:381-399(2008).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18196551}. Nucleus
CC       {ECO:0000269|PubMed:18196551}.
CC   -!- TISSUE SPECIFICITY: Abundant expression is found in prostate,
CC       restricted to cells of epithelial origin in normal and diseased glands.
CC       Very low expression is detected in pancreas and ovary.
CC       {ECO:0000269|PubMed:18196551}.
CC   -!- INDUCTION: By androgens. {ECO:0000269|PubMed:18196551}.
CC   -!- CAUTION: Was named (PubMed:18196551) 'Kallikrein-related in prostate
CC       protein 1' because this protein is encoded by a transcript from the
CC       KLKP1 gene region. It is encoded in an exon which is similar to the
CC       intronic region between exons 1 and 2 of KLK1, KLK2 and KLK3.
CC       {ECO:0000305|PubMed:18196551}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; DQ211698; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; DQ086829; AAZ78651.1; -; mRNA.
DR   EMBL; DQ086830; AAZ78652.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q107X0; -.
DR   BioMuta; HGNC:21260; -.
DR   PRIDE; Q107X0; -.
DR   GeneCards; KLKP1; -.
DR   HGNC; HGNC:21260; KLKP1.
DR   neXtProt; NX_Q107X0; -.
DR   Pharos; Q107X0; Tdark.
DR   PRO; PR:Q107X0; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q107X0; protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   5: Uncertain;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..134
FT                   /note="Putative protein KRIP1"
FT                   /id="PRO_0000341220"
FT   REGION          1..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   134 AA;  14401 MW;  29EECF9BB8351706 CRC64;
     MSPVHRSRTS QTQEAHKPTS TLSFISPPQP PRQDPKSPHI LCSQPNACSR QSHVSYPNPW
     GLPCSQSKVS PPGTATNPNP KEWSRISGPP VSLDPQPWSS APFKPTAQLP LLAQSLGPPA
     KPALPDPALP LQML