ID   KRP1_ORYSJ              Reviewed;         262 AA.
AC   Q6Z6G5; A3ABM2; B7EU31;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Cyclin-dependent kinase inhibitor 1;
DE   AltName: Full=KIP-related protein 1;
GN   Name=KRP1; OrderedLocusNames=Os02g0762400, LOC_Os02g52480;
GN   ORFNames=OsJ_008194, P0486G03.18;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=17012406; DOI=10.1104/pp.106.087056;
RA   Barroco R.M., Peres A., Droual A.-M., de Veylder L., Nguyen L.S.L.,
RA   de Wolf J., Mironov V., Peerbolte R., Beemster G.T.S., Inze D.,
RA   Broekaert W.F., Frankard V.;
RT   "The cyclin-dependent kinase inhibitor Orysa;KRP1 plays an important role
RT   in seed development of rice.";
RL   Plant Physiol. 142:1053-1064(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [7]
RP   INDUCTION, AND GENE FAMILY.
RX   PubMed=17443292; DOI=10.1007/s11103-007-9154-y;
RA   Guo J., Song J., Wang F., Zhang X.S.;
RT   "Genome-wide identification and expression analysis of rice cell cycle
RT   genes.";
RL   Plant Mol. Biol. 64:349-360(2007).
CC   -!- FUNCTION: Regulates the production of endosperm cells, affecting seed
CC       filling and embryo development. Regulates endoreduplication of
CC       endosperm cells. May play a role in the exit from the mitotic cell
CC       cycle during rice grain formation. Inhibitis leaf elongation rates by
CC       decreasing cell number, that is partly compensated by increased cell
CC       size. May not affect growth rate or cell size of the primary root.
CC       {ECO:0000269|PubMed:17012406}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves and apex.
CC       {ECO:0000269|PubMed:17012406}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout seed development in the
CC       pericarp and endosperm tissues with a peak at 8 days after pollination
CC       in the outermost cell layers located centripetally to the endosperm.
CC       {ECO:0000269|PubMed:17012406}.
CC   -!- INDUCTION: Down-regulated by cytokinin. {ECO:0000269|PubMed:17443292}.
CC   -!- MISCELLANEOUS: Plants overexpressing KRP1 show a reduction in the
CC       filling rate of about 2/3, and no embryo is observed in the empty seeds
CC       or seeds containing underdeveloped endosperm.
CC   -!- SIMILARITY: Belongs to the CDI family. ICK/KRP subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAZ24711.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DQ229362; ABB70058.1; -; mRNA.
DR   EMBL; AP005002; BAD17213.1; -; Genomic_DNA.
DR   EMBL; AP008208; BAF10118.1; -; Genomic_DNA.
DR   EMBL; AP014958; BAS81044.1; -; Genomic_DNA.
DR   EMBL; CM000139; EAZ24711.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AK103084; BAG95878.1; -; mRNA.
DR   RefSeq; XP_015623243.1; XM_015767757.1.
DR   AlphaFoldDB; Q6Z6G5; -.
DR   STRING; 4530.OS02T0762400-01; -.
DR   PaxDb; Q6Z6G5; -.
DR   PRIDE; Q6Z6G5; -.
DR   EnsemblPlants; Os02t0762400-01; Os02t0762400-01; Os02g0762400.
DR   GeneID; 4330816; -.
DR   Gramene; Os02t0762400-01; Os02t0762400-01; Os02g0762400.
DR   KEGG; osa:4330816; -.
DR   eggNOG; ENOG502RZHP; Eukaryota.
DR   HOGENOM; CLU_062111_0_0_1; -.
DR   InParanoid; Q6Z6G5; -.
DR   OMA; THETSHS; -.
DR   OrthoDB; 1565980at2759; -.
DR   PlantReactome; R-OSA-9630286; Cell cycle regulation.
DR   PlantReactome; R-OSA-9640760; G1 phase.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000007752; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   Genevisible; Q6Z6G5; OS.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.365.10; -; 1.
DR   InterPro; IPR003175; CDI_dom.
DR   InterPro; IPR044898; CDI_dom_sf.
DR   InterPro; IPR044275; KRP.
DR   PANTHER; PTHR46776; PTHR46776; 1.
DR   Pfam; PF02234; CDI; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Protein kinase inhibitor;
KW   Reference proteome.
FT   CHAIN           1..262
FT                   /note="Cyclin-dependent kinase inhibitor 1"
FT                   /id="PRO_0000295663"
FT   REGION          140..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   262 AA;  27138 MW;  42EC85C8276C0726 CRC64;
     MGKYMRKFRG ATGEELAAME VTQVVGVRTR SRSAAAAGAT TTKVKAASAA STRRRKALLP
     TAVVGTTRRD GGSCYLQLRS RMLFMAPPRP APAARAPVVA EAAGSGNGAA AHAAAGLSRC
     SSTASSVDAA AQDRSLACRS DVAEAGSEHV PEGSASDSAS GRDRERRETT PSSFLPGEVS
     DLESDLAGGQ KRSRPLPSAA TASAQQATRP KIPPAAEIEA FFAAAEEAEA KRFAAKYNFD
     VVRGVPLDAG RFEWTPVVSS RS