KRP5_ARATH
ID KRP5_ARATH Reviewed; 189 AA.
AC Q9LRY0;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Cyclin-dependent kinase inhibitor 5;
DE AltName: Full=Inhibitor/interactor of CDK protein 3;
DE AltName: Full=KIP-related protein 5;
GN Name=KRP5; Synonyms=ICK3; OrderedLocusNames=At3g24810; ORFNames=K7P8.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH
RP CYCD4-1.
RC STRAIN=cv. Columbia;
RX PubMed=11449057; DOI=10.2307/3871392;
RA de Veylder L., Beeckman T., Beemster G.T.S., Krols L., Terras F.,
RA Landrieu I., van der Schueren E., Maes S., Naudts M., Inze D.;
RT "Functional analysis of cyclin-dependent kinase inhibitors of
RT Arabidopsis.";
RL Plant Cell 13:1653-1667(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RX PubMed=16376885; DOI=10.1016/j.febslet.2005.12.018;
RA Nakai T., Kato K., Shinmyo A., Sekine M.;
RT "Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-
RT associated kinases, including plant-specific B-type cyclin-dependent
RT kinase.";
RL FEBS Lett. 580:336-340(2006).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=17253089; DOI=10.1007/s00299-006-0294-3;
RA Bird D.A., Buruiana M.M., Zhou Y., Fowke L.C., Wang H.;
RT "Arabidopsis cyclin-dependent kinase inhibitors are nuclear-localized and
RT show different localization patterns within the nucleoplasm.";
RL Plant Cell Rep. 26:861-872(2007).
CC -!- FUNCTION: Inhibits CYCD2-1/CDKA-1 complex kinase activity without
CC interaction with the complex. {ECO:0000269|PubMed:16376885}.
CC -!- SUBUNIT: Interacts with CYCD4-1. Does not interact with CDKA-1.
CC {ECO:0000269|PubMed:11449057}.
CC -!- INTERACTION:
CC Q9LRY0; P24100: CDKA-1; NbExp=3; IntAct=EBI-1636764, EBI-371713;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000269|PubMed:17253089}. Note=Distributed in a ponctuate pattern.
CC -!- TISSUE SPECIFICITY: Expressed in flowers and at lower levels in roots
CC and leaves. {ECO:0000269|PubMed:11449057}.
CC -!- SIMILARITY: Belongs to the CDI family. ICK/KRP subfamily.
CC {ECO:0000305}.
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DR EMBL; AJ301556; CAC41619.1; -; mRNA.
DR EMBL; AB028609; BAB02891.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76949.1; -; Genomic_DNA.
DR EMBL; BT025751; ABF83641.1; -; mRNA.
DR EMBL; AK228811; BAF00707.1; -; mRNA.
DR RefSeq; NP_189125.1; NM_113393.3.
DR AlphaFoldDB; Q9LRY0; -.
DR SMR; Q9LRY0; -.
DR BioGRID; 7410; 17.
DR IntAct; Q9LRY0; 10.
DR STRING; 3702.AT3G24810.1; -.
DR PaxDb; Q9LRY0; -.
DR PRIDE; Q9LRY0; -.
DR ProteomicsDB; 250703; -.
DR EnsemblPlants; AT3G24810.1; AT3G24810.1; AT3G24810.
DR GeneID; 822079; -.
DR Gramene; AT3G24810.1; AT3G24810.1; AT3G24810.
DR KEGG; ath:AT3G24810; -.
DR Araport; AT3G24810; -.
DR TAIR; locus:2087248; AT3G24810.
DR eggNOG; ENOG502QXA1; Eukaryota.
DR HOGENOM; CLU_083146_0_0_1; -.
DR InParanoid; Q9LRY0; -.
DR OMA; CGDNERI; -.
DR OrthoDB; 1397852at2759; -.
DR PhylomeDB; Q9LRY0; -.
DR PRO; PR:Q9LRY0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LRY0; baseline and differential.
DR Genevisible; Q9LRY0; AT.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031490; F:chromatin DNA binding; IDA:CACAO.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:TAIR.
DR GO; GO:0032877; P:positive regulation of DNA endoreduplication; IMP:CACAO.
DR Gene3D; 4.10.365.10; -; 1.
DR InterPro; IPR003175; CDI_dom.
DR InterPro; IPR044898; CDI_dom_sf.
DR InterPro; IPR044275; KRP.
DR PANTHER; PTHR46776; PTHR46776; 1.
DR Pfam; PF02234; CDI; 1.
DR PIRSF; PIRSF017811; CDK_inhib_pln; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Nucleus; Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..189
FT /note="Cyclin-dependent kinase inhibitor 5"
FT /id="PRO_0000294089"
FT REGION 73..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 189 AA; 21424 MW; A66041310E8DDED6 CRC64;
MGKYIKKSKV AGAVSVKDKS HPPALGFRTR AAAAKNLALH RLRSHSDEAD SFNYLQLRSR
RLVKLPLLTN TRKQQKQQLI PSVNQCQTKN PRASSGPAKK LEPDTTTEEA CGDNERISRS
DCNFGDKGFD LESENRSMIS DSKSIQSEIE DFFASAEQQQ QRFFIQKYNF DIVSDNPLPG
RYEWVKVMP
