ID   KRR1_DICDI              Reviewed;         374 AA.
AC   Q54UU6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=KRR1 small subunit processome component homolog;
DE   AltName: Full=KRR-R motif-containing protein 1;
GN   Name=krr1; ORFNames=DDB_G0280805;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar
CC       processing of pre-18S ribosomal RNA and ribosome assembly (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRR1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000038; EAL67060.1; -; Genomic_DNA.
DR   RefSeq; XP_641041.1; XM_635949.1.
DR   AlphaFoldDB; Q54UU6; -.
DR   SMR; Q54UU6; -.
DR   STRING; 44689.DDB0204743; -.
DR   PaxDb; Q54UU6; -.
DR   EnsemblProtists; EAL67060; EAL67060; DDB_G0280805.
DR   GeneID; 8622743; -.
DR   KEGG; ddi:DDB_G0280805; -.
DR   dictyBase; DDB_G0280805; -.
DR   eggNOG; KOG2874; Eukaryota.
DR   HOGENOM; CLU_040185_0_0_1; -.
DR   InParanoid; Q54UU6; -.
DR   OMA; HKKEKFV; -.
DR   PhylomeDB; Q54UU6; -.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q54UU6; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR041174; KH_8.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR024166; rRNA_assembly_KRR1.
DR   PANTHER; PTHR12581; PTHR12581; 1.
DR   Pfam; PF17903; KH_8; 1.
DR   PIRSF; PIRSF006515; KRR1; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..374
FT                   /note="KRR1 small subunit processome component homolog"
FT                   /id="PRO_0000342399"
FT   DOMAIN          141..211
FT                   /note="KH"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..34
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        279..324
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..350
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   374 AA;  43790 MW;  E0D427DCD9804AA8 CRC64;
     MGKKDKTEIK VEEENKEKKQ YKKKKEREEL EIPKGIDPWK PLELKRDDVG KRVLYDDSSF
     ATLFPKYREK YLQEIWKLVE NVLHEHGIEC KLDLIEGSMT VTTTKKCWDP VAILKARDLI
     KLLSRSVPFE HAQKVLNDDY NCDIIKIGGF VRNKERFVKR RQRLVGPDGS TLKAIELLTK
     CYVLVQGNTV SSIGPWNGLV QVRKIVEDCL KNIHPIYNIK ELMIKRELEK DETLKNENWE
     RYLPQFKKTN QNKKKKVQKK KKDRDAAPFA PPQLPRKEDL AMESGEYFAS EEKKRRKIQA
     DREAKHAESD QKRKDERQKS QIAPAEKDRS TTTTTNTSNI QDTLSNIKNN LKNNKRKEAP
     TNNADDFVLK KNKK