ID   KRR1_DROAN              Reviewed;         343 AA.
AC   B3MM49;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=KRR1 small subunit processome component homolog {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=KRR-R motif-containing protein 1 {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=Protein dribble {ECO:0000250|UniProtKB:Q9VPU8};
GN   Name=dbe {ECO:0000250|UniProtKB:Q9VPU8};
GN   Synonyms=dribble {ECO:0000250|UniProtKB:Q9VPU8}; ORFNames=GF14827;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1] {ECO:0000312|EMBL:EDV30864.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13 {ECO:0000312|EMBL:EDV30864.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar
CC       processing of pre-18S ribosomal RNA and ribosome assembly. Binds to
CC       RNA. Required for female germline development, cell viability during
CC       eye development and for survival of dividing cells and epithelial cells
CC       during early wing disk development (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBUNIT: Monomer. Component of the ribosomal small subunit (SSU)
CC       processome (By similarity). {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SIMILARITY: Belongs to the KRR1 family. {ECO:0000255}.
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DR   EMBL; CH902620; EDV30864.1; -; Genomic_DNA.
DR   RefSeq; XP_001961643.1; XM_001961607.2.
DR   AlphaFoldDB; B3MM49; -.
DR   SMR; B3MM49; -.
DR   STRING; 7217.FBpp0118019; -.
DR   EnsemblMetazoa; FBtr0119527; FBpp0118019; FBgn0091854.
DR   GeneID; 6497645; -.
DR   KEGG; dan:6497645; -.
DR   eggNOG; KOG2874; Eukaryota.
DR   HOGENOM; CLU_040185_0_2_1; -.
DR   InParanoid; B3MM49; -.
DR   OMA; HKKEKFV; -.
DR   OrthoDB; 944899at2759; -.
DR   PhylomeDB; B3MM49; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR041174; KH_8.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR024166; rRNA_assembly_KRR1.
DR   PANTHER; PTHR12581; PTHR12581; 1.
DR   Pfam; PF17903; KH_8; 1.
DR   PIRSF; PIRSF006515; KRR1; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; Nucleus; Reference proteome;
KW   Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..343
FT                   /note="KRR1 small subunit processome component homolog"
FT                   /id="PRO_0000415651"
FT   DOMAIN          125..193
FT                   /note="KH"
FT                   /evidence="ECO:0000255"
FT   REGION          232..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          270..302
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        273..315
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   343 AA;  39345 MW;  E949135CE4EC47AC CRC64;
     MSDSETEETK ISTEPVENAW AMKIPSFKPE DNPHGMVEES SFATLFPKYR ERYLKEVWPL
     VEQCVAEHHL KAELDLVEGS MVVKTSRKTW DPYIIIKARD MIKLMARSVP FEQAKRVLQD
     DIGCDIIKIG NLVHKKEKFV KRRQRLIGPN GATLKSIELL TDCYVLVQGN TVAALGPYKG
     LQQVRDIVVE TMNNVHPIYN IKALMIKREL MKDPRLANED WSRFLPKFKN KNISKRKQPK
     VKKAKKEYTP FPPAQPESKV GKQLASGEYF LNKEQKQAKR QQERSAKQAD AAKRQDERRN
     KDFVPPTEEA SSSRKRSSAE NASSKVDVKA LKAKLLKANK KKV