ID   KRR1_DROER              Reviewed;         345 AA.
AC   B3N899;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=KRR1 small subunit processome component homolog {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=KRR-R motif-containing protein 1 {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=Protein dribble {ECO:0000250|UniProtKB:Q9VPU8};
GN   Name=dbe {ECO:0000250|UniProtKB:Q9VPU8};
GN   Synonyms=dribble {ECO:0000250|UniProtKB:Q9VPU8}; ORFNames=GG24622;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1] {ECO:0000312|EMBL:EDV57286.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV57286.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar
CC       processing of pre-18S ribosomal RNA and ribosome assembly. Binds to
CC       RNA. Required for female germline development, cell viability during
CC       eye development and for survival of dividing cells and epithelial cells
CC       during early wing disk development (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBUNIT: Monomer. Component of the ribosomal small subunit (SSU)
CC       processome (By similarity). {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SIMILARITY: Belongs to the KRR1 family. {ECO:0000255}.
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DR   EMBL; CH954177; EDV57286.1; -; Genomic_DNA.
DR   RefSeq; XP_001968227.1; XM_001968191.2.
DR   AlphaFoldDB; B3N899; -.
DR   SMR; B3N899; -.
DR   STRING; 7220.FBpp0143168; -.
DR   EnsemblMetazoa; FBtr0144676; FBpp0143168; FBgn0116754.
DR   GeneID; 6543024; -.
DR   KEGG; der:6543024; -.
DR   eggNOG; KOG2874; Eukaryota.
DR   HOGENOM; CLU_040185_0_2_1; -.
DR   OMA; HKKEKFV; -.
DR   OrthoDB; 944899at2759; -.
DR   PhylomeDB; B3N899; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR041174; KH_8.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR024166; rRNA_assembly_KRR1.
DR   PANTHER; PTHR12581; PTHR12581; 1.
DR   Pfam; PF17903; KH_8; 1.
DR   PIRSF; PIRSF006515; KRR1; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; Nucleus; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..345
FT                   /note="KRR1 small subunit processome component homolog"
FT                   /id="PRO_0000415652"
FT   DOMAIN          125..193
FT                   /note="KH"
FT                   /evidence="ECO:0000255"
FT   REGION          232..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          270..298
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        277..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..329
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  39891 MW;  6F2589D287AAFE81 CRC64;
     MSESDAEETK ISTDPVDNAW AMKIPTFREE DNPHGMVEES SFATLFPKYR ERYLKEVWPL
     VEQCLAEHHL KAELDLMEGS MVVRTSRKTW DPYIIIKARD MIKLMARSVP FEQAKRVLQD
     DIGCDIIKIG NLVHKKEKFV KRRQRLIGPN GATLKSIELL TDCYVLVQGN TVSALGPYKG
     LQQVRDIVLE TMNNVHPIYN IKALMIKREL MKDPRLANED WSRFLPKFKN KNISKRKQPK
     VKKQKKEYTP FPPSQPESKV DKQLASGEYF LNQEQKQAKR NQERTEKQKE AAKRQDERRN
     KDFVPPTEES ASSSLKKEDG FSSSKVDVKA LKAKLIKANK KARSS