ID   KRR1_DROGR              Reviewed;         341 AA.
AC   B4JDU5;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=KRR1 small subunit processome component homolog {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=KRR-R motif-containing protein 1 {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=Protein dribble {ECO:0000250|UniProtKB:Q9VPU8};
GN   Name=dbe {ECO:0000250|UniProtKB:Q9VPU8};
GN   Synonyms=dribble {ECO:0000250|UniProtKB:Q9VPU8}; ORFNames=GH10489;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1] {ECO:0000312|EMBL:EDW03465.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDW03465.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar
CC       processing of pre-18S ribosomal RNA and ribosome assembly. Binds to
CC       RNA. Required for female germline development, cell viability during
CC       eye development and for survival of dividing cells and epithelial cells
CC       during early wing disk development (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBUNIT: Monomer. Component of the ribosomal small subunit (SSU)
CC       processome (By similarity). {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SIMILARITY: Belongs to the KRR1 family. {ECO:0000255}.
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DR   EMBL; CH916368; EDW03465.1; -; Genomic_DNA.
DR   RefSeq; XP_001988598.1; XM_001988562.1.
DR   AlphaFoldDB; B4JDU5; -.
DR   SMR; B4JDU5; -.
DR   STRING; 7222.FBpp0144395; -.
DR   EnsemblMetazoa; FBtr0145903; FBpp0144395; FBgn0117970.
DR   GeneID; 6562924; -.
DR   KEGG; dgr:6562924; -.
DR   eggNOG; KOG2874; Eukaryota.
DR   HOGENOM; CLU_040185_0_2_1; -.
DR   InParanoid; B4JDU5; -.
DR   OMA; HKKEKFV; -.
DR   OrthoDB; 944899at2759; -.
DR   PhylomeDB; B4JDU5; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR041174; KH_8.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR024166; rRNA_assembly_KRR1.
DR   PANTHER; PTHR12581; PTHR12581; 1.
DR   Pfam; PF17903; KH_8; 1.
DR   PIRSF; PIRSF006515; KRR1; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; Nucleus; Reference proteome;
KW   Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..341
FT                   /note="KRR1 small subunit processome component homolog"
FT                   /id="PRO_0000415653"
FT   DOMAIN          126..194
FT                   /note="KH"
FT                   /evidence="ECO:0000255"
FT   REGION          230..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          271..341
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        274..327
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  39382 MW;  D4B58FCD7AE9F8D4 CRC64;
     MSDSETEETT KQSTEPVDNA WSLKIPTFKA EDNPHGMVEE SSFATLFPKY REKYLKEVWP
     LVQQTVAEHH LRAELDLIEG SMVVKTTRKT WDPYIIIKSR DMIKLMARSV PFEQAKRVLQ
     DETGCDIIKI GNLVHKKEKF VKRRQRLIGP NGATLKSIEL LTDCYVLVQG NTVAALGPYK
     GLQQVRDIVL ETMNNVHPIY NIKALMIKRE LMKDPQLANE DWSRFLPKFK NKNISKRKQP
     KSRKPKGEYT PFPPAQPESK IDKQLASGEY FLNKEQKQAK RQQERVAKQA EAAKKQDERR
     NKDFMPPTED SPEQNRKRPS EASKVDVKAL KAKLLKANKQ K