ID   KRR1_DROWI              Reviewed;         347 AA.
AC   B4N0P7;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=KRR1 small subunit processome component homolog {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=KRR-R motif-containing protein 1 {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=Protein dribble {ECO:0000250|UniProtKB:Q9VPU8};
GN   Name=dbe {ECO:0000250|UniProtKB:Q9VPU8};
GN   Synonyms=dribble {ECO:0000250|UniProtKB:Q9VPU8}; ORFNames=GK24616;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1] {ECO:0000312|EMBL:EDW77660.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW77660.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar
CC       processing of pre-18S ribosomal RNA and ribosome assembly. Binds to
CC       RNA. Required for female germline development, cell viability during
CC       eye development and for survival of dividing cells and epithelial cells
CC       during early wing disk development (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBUNIT: Monomer. Component of the ribosomal small subunit (SSU)
CC       processome (By similarity). {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SIMILARITY: Belongs to the KRR1 family. {ECO:0000255}.
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DR   EMBL; CH963920; EDW77660.1; -; Genomic_DNA.
DR   RefSeq; XP_002066674.1; XM_002066638.2.
DR   AlphaFoldDB; B4N0P7; -.
DR   SMR; B4N0P7; -.
DR   STRING; 7260.FBpp0253759; -.
DR   EnsemblMetazoa; FBtr0255267; FBpp0253759; FBgn0226576.
DR   GeneID; 6644377; -.
DR   KEGG; dwi:6644377; -.
DR   eggNOG; KOG2874; Eukaryota.
DR   HOGENOM; CLU_040185_0_2_1; -.
DR   InParanoid; B4N0P7; -.
DR   OMA; HKKEKFV; -.
DR   OrthoDB; 944899at2759; -.
DR   PhylomeDB; B4N0P7; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR041174; KH_8.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR024166; rRNA_assembly_KRR1.
DR   PANTHER; PTHR12581; PTHR12581; 1.
DR   Pfam; PF17903; KH_8; 1.
DR   PIRSF; PIRSF006515; KRR1; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; Nucleus; Reference proteome;
KW   Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..347
FT                   /note="KRR1 small subunit processome component homolog"
FT                   /id="PRO_0000415657"
FT   DOMAIN          124..194
FT                   /note="KH"
FT                   /evidence="ECO:0000255"
FT   REGION          231..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          271..304
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        274..306
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..330
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  39887 MW;  88F243AA1111F0DA CRC64;
     MSDSESEEAT KINTDPVDNA WSLKIPAFKE TDNPHGMIEE SSFATLFPKY REKYLKEVWP
     LVEQAVGEHH LKAELDLVEG SMVVKTTRKT WDPYIIIKAR DMIKLMARSV PFEQAKRVLQ
     DEIGCDIIKI GNLVQKKEKF VKRRQRLIGP NGATLKSIEL LTDCYVLVQG NTVSALGPYK
     GLQQVRDIVL ETMNNVHPIY NIKALMIKRE LMKDPKLANE DWSRFLPKFK NKNLSKRKQP
     KVKKPKKEYT PFPPAQPESK IDKQLASGEY FLNKEQKQAK RQQERQTKQA EAAKKQDERR
     NKDFIPPTEE PPTGSKRKAN DNDSSDSRVD VQSLKAKLLK ANKKSKS