ID   KRR1_DROYA              Reviewed;         344 AA.
AC   B4P2Y8;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=KRR1 small subunit processome component homolog {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=KRR-R motif-containing protein 1 {ECO:0000250|UniProtKB:Q9VPU8};
DE   AltName: Full=Protein dribble {ECO:0000250|UniProtKB:Q9VPU8};
GN   Name=dbe {ECO:0000250|UniProtKB:Q9VPU8};
GN   Synonyms=dribble {ECO:0000250|UniProtKB:Q9VPU8}; ORFNames=GE15854;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000312|EMBL:EDW87195.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW87195.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar
CC       processing of pre-18S ribosomal RNA and ribosome assembly. Binds to
CC       RNA. Required for female germline development, cell viability during
CC       eye development and for survival of dividing cells and epithelial cells
CC       during early wing disk development (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBUNIT: Monomer. Component of the ribosomal small subunit (SSU)
CC       processome (By similarity). {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9VPU8}.
CC   -!- SIMILARITY: Belongs to the KRR1 family. {ECO:0000255}.
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DR   EMBL; CM000157; EDW87195.1; -; Genomic_DNA.
DR   RefSeq; XP_002087483.1; XM_002087447.2.
DR   AlphaFoldDB; B4P2Y8; -.
DR   SMR; B4P2Y8; -.
DR   STRING; 7245.FBpp0260864; -.
DR   PRIDE; B4P2Y8; -.
DR   EnsemblMetazoa; FBtr0262372; FBpp0260864; FBgn0233416.
DR   GeneID; 6526362; -.
DR   KEGG; dya:Dyak_GE15854; -.
DR   eggNOG; KOG2874; Eukaryota.
DR   HOGENOM; CLU_040185_0_2_1; -.
DR   OMA; HKKEKFV; -.
DR   OrthoDB; 944899at2759; -.
DR   PhylomeDB; B4P2Y8; -.
DR   Proteomes; UP000002282; Chromosome 2L.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR041174; KH_8.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR024166; rRNA_assembly_KRR1.
DR   PANTHER; PTHR12581; PTHR12581; 1.
DR   Pfam; PF17903; KH_8; 1.
DR   PIRSF; PIRSF006515; KRR1; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; Nucleus; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..344
FT                   /note="KRR1 small subunit processome component homolog"
FT                   /id="PRO_0000415658"
FT   DOMAIN          125..193
FT                   /note="KH"
FT                   /evidence="ECO:0000255"
FT   REGION          232..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          270..295
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        279..326
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   344 AA;  39668 MW;  F01F299E1B0ED3FB CRC64;
     MSESEAEETK ISTEPVDNAW AMKIPTFRQE DNPHGVVEES SFATLFPKYR ERYLKEVWPL
     VEQCLSEHHL KAELDLMEGS MVVKTSRKTW DPYIIIKARD MIKLMARSVP FEQAKRVLQD
     DIGCDIIKIG NLVHKKEKFV KRRQRLIGPN GATLKSIELL TDCYVLVQGN TVSALGPYKG
     LQQVRDIVLE TMNNVHPIYN IKALMIKREL MKDPRLANED WSRFLPKFKN KNISKRKQPK
     VKKQKKEYTP FPPSQPESKV DKQLASGEYF LNQEQKQAKR NQGRTEKQKE AAKRQDERRN
     KDFVPPTEES AASSRKKEDG SSTKVDVKAL KAKLIKANKK AKSS