KRR1_SCHPO
ID KRR1_SCHPO Reviewed; 327 AA.
AC O74777;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=KRR1 small subunit processome component homolog;
DE AltName: Full=KRR-R motif-containing protein 1;
DE AltName: Full=Ribosomal RNA assembly protein mis3;
GN Name=mis3; Synonyms=krr1; ORFNames=SPBC25B2.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=10947840; DOI=10.1046/j.1365-2443.2000.00344.x;
RA Kondoh H., Yuasa T., Yanagida M.;
RT "Mis3 with a conserved RNA binding motif is essential for ribosome
RT biogenesis and implicated in the start of cell growth and S phase
RT checkpoint.";
RL Genes Cells 5:525-541(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar
CC processing of pre-18S ribosomal RNA and ribosome assembly.
CC {ECO:0000269|PubMed:10947840}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10947840,
CC ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the KRR1 family. {ECO:0000305}.
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DR EMBL; AB030208; BAA82594.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA21263.1; -; Genomic_DNA.
DR PIR; T39981; T39981.
DR RefSeq; NP_596073.1; NM_001021985.2.
DR AlphaFoldDB; O74777; -.
DR SMR; O74777; -.
DR BioGRID; 277071; 10.
DR STRING; 4896.SPBC25B2.05.1; -.
DR iPTMnet; O74777; -.
DR MaxQB; O74777; -.
DR PaxDb; O74777; -.
DR PRIDE; O74777; -.
DR EnsemblFungi; SPBC25B2.05.1; SPBC25B2.05.1:pep; SPBC25B2.05.
DR GeneID; 2540544; -.
DR KEGG; spo:SPBC25B2.05; -.
DR PomBase; SPBC25B2.05; mis3.
DR VEuPathDB; FungiDB:SPBC25B2.05; -.
DR eggNOG; KOG2874; Eukaryota.
DR HOGENOM; CLU_040185_0_2_1; -.
DR InParanoid; O74777; -.
DR OMA; HKKEKFV; -.
DR PhylomeDB; O74777; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O74777; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0003723; F:RNA binding; ISM:PomBase.
DR GO; GO:0006364; P:rRNA processing; IMP:PomBase.
DR Gene3D; 3.30.1370.10; -; 2.
DR InterPro; IPR041174; KH_8.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR024166; rRNA_assembly_KRR1.
DR PANTHER; PTHR12581; PTHR12581; 1.
DR Pfam; PF17903; KH_8; 1.
DR PIRSF; PIRSF006515; KRR1; 1.
DR SUPFAM; SSF54791; SSF54791; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW RNA-binding; rRNA processing.
FT CHAIN 1..327
FT /note="KRR1 small subunit processome component homolog"
FT /id="PRO_0000050121"
FT DOMAIN 135..205
FT /note="KH"
FT REGION 247..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 38588 MW; 895407C9D92C02F8 CRC64;
MTEVESSTEN NVIVNKNKRY RRDKPWDTDD IDHWKIEPFT KDDSKESFLE ESSFATLFPK
YREKYLREVW PHVTRALDKF GITCVLDLVE GSMTVKTTRK TFDPYSILDA RDLIKLLARS
VPFPQAVKIM QDGVACDIIK IGNILRNKER FVKRRQRLIG TNGQTLKALE LLTQCYILVQ
GTTVAVMGGY KGLKEVRRIV EDCMHNIHPI YHIKELMIKR ELAKDPTLAN ESWDRFLPQF
KKRNVARRKP AKIRETKEYT PFPPAQPPSK LDLEIESGEY FLKKEEKERK KRAEKKEQQK
EKKKEKEKER MKAFIPPEES SKKRKRD
