KRT34_HUMAN
ID KRT34_HUMAN Reviewed; 436 AA.
AC O76011; Q8IUT8; Q8N4W2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Keratin, type I cuticular Ha4;
DE AltName: Full=Hair keratin, type I Ha4;
DE AltName: Full=Keratin-34;
DE Short=K34;
GN Name=KRT34; Synonyms=HHA4, HKA4, KRTHA4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT "Characterization of a 190-kilobase pair domain of human type I hair
RT keratin genes.";
RL J. Biol. Chem. 273:26683-26691(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-280.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC O76011; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-1047093, EBI-2809489;
CC O76011; Q6UXT9: ABHD15; NbExp=3; IntAct=EBI-1047093, EBI-2824666;
CC O76011; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-1047093, EBI-11096309;
CC O76011; P18825: ADRA2C; NbExp=3; IntAct=EBI-1047093, EBI-12015266;
CC O76011; P21549: AGXT; NbExp=3; IntAct=EBI-1047093, EBI-727098;
CC O76011; Q13155: AIMP2; NbExp=3; IntAct=EBI-1047093, EBI-745226;
CC O76011; P43353: ALDH3B1; NbExp=3; IntAct=EBI-1047093, EBI-2558314;
CC O76011; A2BDD9: AMOT; NbExp=3; IntAct=EBI-1047093, EBI-17286414;
CC O76011; X5D778: ANKRD11; NbExp=3; IntAct=EBI-1047093, EBI-17183751;
CC O76011; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-1047093, EBI-11954519;
CC O76011; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-1047093, EBI-742909;
CC O76011; O95671: ASMTL; NbExp=3; IntAct=EBI-1047093, EBI-743231;
CC O76011; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-1047093, EBI-12006308;
CC O76011; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-1047093, EBI-1166928;
CC O76011; Q8N1L9: BATF2; NbExp=3; IntAct=EBI-1047093, EBI-742695;
CC O76011; O75934: BCAS2; NbExp=5; IntAct=EBI-1047093, EBI-1050106;
CC O76011; Q9HBH7: BEX1; NbExp=3; IntAct=EBI-1047093, EBI-7162175;
CC O76011; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-1047093, EBI-745073;
CC O76011; Q00994: BEX3; NbExp=3; IntAct=EBI-1047093, EBI-741753;
CC O76011; Q8NDY6: BHLHE23; NbExp=3; IntAct=EBI-1047093, EBI-12144263;
CC O76011; Q53S33: BOLA3; NbExp=3; IntAct=EBI-1047093, EBI-12086950;
CC O76011; Q0VDD7-2: BRME1; NbExp=3; IntAct=EBI-1047093, EBI-12040255;
CC O76011; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-1047093, EBI-6660291;
CC O76011; Q8WW18: C17orf50; NbExp=3; IntAct=EBI-1047093, EBI-12877892;
CC O76011; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-1047093, EBI-747505;
CC O76011; A4QMS7: C5orf49; NbExp=3; IntAct=EBI-1047093, EBI-12039847;
CC O76011; Q9HC52: CBX8; NbExp=3; IntAct=EBI-1047093, EBI-712912;
CC O76011; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-1047093, EBI-744556;
CC O76011; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-1047093, EBI-10961312;
CC O76011; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-1047093, EBI-10749669;
CC O76011; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-1047093, EBI-10181422;
CC O76011; E9PSE9: CCDC198; NbExp=3; IntAct=EBI-1047093, EBI-11748295;
CC O76011; Q8N4L8: CCDC24; NbExp=5; IntAct=EBI-1047093, EBI-1104933;
CC O76011; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-1047093, EBI-10175300;
CC O76011; P24863: CCNC; NbExp=3; IntAct=EBI-1047093, EBI-395261;
CC O76011; Q86Y33-5: CDC20B; NbExp=3; IntAct=EBI-1047093, EBI-11983537;
CC O76011; Q07002: CDK18; NbExp=3; IntAct=EBI-1047093, EBI-746238;
CC O76011; Q8TCT0: CERK; NbExp=3; IntAct=EBI-1047093, EBI-10274247;
CC O76011; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-1047093, EBI-749051;
CC O76011; Q96M91: CFAP53; NbExp=3; IntAct=EBI-1047093, EBI-742422;
CC O76011; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-1047093, EBI-947551;
CC O76011; P07510-2: CHRNG; NbExp=3; IntAct=EBI-1047093, EBI-11979451;
CC O76011; P51800-3: CLCNKA; NbExp=3; IntAct=EBI-1047093, EBI-11980535;
CC O76011; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-1047093, EBI-12256978;
CC O76011; A5D8T8: CLEC18A; NbExp=3; IntAct=EBI-1047093, EBI-10173491;
CC O76011; Q99895: CTRC; NbExp=3; IntAct=EBI-1047093, EBI-10295404;
CC O76011; Q9NXE8: CWC25; NbExp=3; IntAct=EBI-1047093, EBI-746052;
CC O76011; A8MQ03: CYSRT1; NbExp=5; IntAct=EBI-1047093, EBI-3867333;
CC O76011; Q9UIA0: CYTH4; NbExp=3; IntAct=EBI-1047093, EBI-11521003;
CC O76011; O75935-2: DCTN3; NbExp=3; IntAct=EBI-1047093, EBI-12091947;
CC O76011; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-1047093, EBI-742054;
CC O76011; P26196: DDX6; NbExp=5; IntAct=EBI-1047093, EBI-351257;
CC O76011; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-1047093, EBI-746300;
CC O76011; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-1047093, EBI-9679045;
CC O76011; Q92608: DOCK2; NbExp=3; IntAct=EBI-1047093, EBI-448771;
CC O76011; Q8N7B9-2: EFCAB3; NbExp=3; IntAct=EBI-1047093, EBI-11958551;
CC O76011; Q04637-9: EIF4G1; NbExp=3; IntAct=EBI-1047093, EBI-12012124;
CC O76011; Q9UM22: EPDR1; NbExp=3; IntAct=EBI-1047093, EBI-946972;
CC O76011; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-1047093, EBI-742102;
CC O76011; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-1047093, EBI-371876;
CC O76011; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-1047093, EBI-1752811;
CC O76011; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-1047093, EBI-745689;
CC O76011; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-1047093, EBI-742802;
CC O76011; Q8NEG0: FAM71C; NbExp=3; IntAct=EBI-1047093, EBI-752049;
CC O76011; Q86UY5: FAM83A; NbExp=3; IntAct=EBI-1047093, EBI-1384254;
CC O76011; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-1047093, EBI-6658203;
CC O76011; O95363: FARS2; NbExp=3; IntAct=EBI-1047093, EBI-2513774;
CC O76011; Q969U6: FBXW5; NbExp=5; IntAct=EBI-1047093, EBI-741068;
CC O76011; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-1047093, EBI-744935;
CC O76011; Q9NU39: FOXD4L1; NbExp=3; IntAct=EBI-1047093, EBI-11320806;
CC O76011; O43559: FRS3; NbExp=5; IntAct=EBI-1047093, EBI-725515;
CC O76011; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-1047093, EBI-372506;
CC O76011; P01350: GAST; NbExp=3; IntAct=EBI-1047093, EBI-3436637;
CC O76011; Q86YP4: GATAD2A; NbExp=3; IntAct=EBI-1047093, EBI-726224;
CC O76011; P55040: GEM; NbExp=3; IntAct=EBI-1047093, EBI-744104;
CC O76011; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-1047093, EBI-748515;
CC O76011; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-1047093, EBI-11975289;
CC O76011; P50151: GNG10; NbExp=3; IntAct=EBI-1047093, EBI-10211741;
CC O76011; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-1047093, EBI-11427343;
CC O76011; Q13227: GPS2; NbExp=3; IntAct=EBI-1047093, EBI-713355;
CC O76011; P28799: GRN; NbExp=3; IntAct=EBI-1047093, EBI-747754;
CC O76011; O15499: GSC2; NbExp=3; IntAct=EBI-1047093, EBI-19954058;
CC O76011; P09211: GSTP1; NbExp=3; IntAct=EBI-1047093, EBI-353467;
CC O76011; Q9GZV7: HAPLN2; NbExp=5; IntAct=EBI-1047093, EBI-11956675;
CC O76011; P69905: HBA2; NbExp=3; IntAct=EBI-1047093, EBI-714680;
CC O76011; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-1047093, EBI-14103818;
CC O76011; P08631-2: HCK; NbExp=3; IntAct=EBI-1047093, EBI-9834454;
CC O76011; P56524-2: HDAC4; NbExp=3; IntAct=EBI-1047093, EBI-11953488;
CC O76011; O14964: HGS; NbExp=3; IntAct=EBI-1047093, EBI-740220;
CC O76011; P49639: HOXA1; NbExp=3; IntAct=EBI-1047093, EBI-740785;
CC O76011; P09067: HOXB5; NbExp=3; IntAct=EBI-1047093, EBI-3893317;
CC O76011; P17482: HOXB9; NbExp=3; IntAct=EBI-1047093, EBI-745290;
CC O76011; P31273: HOXC8; NbExp=5; IntAct=EBI-1047093, EBI-1752118;
CC O76011; Q96MM6: HSPA12B; NbExp=3; IntAct=EBI-1047093, EBI-10291310;
CC O76011; P10809: HSPD1; NbExp=3; IntAct=EBI-1047093, EBI-352528;
CC O76011; Q12891: HYAL2; NbExp=3; IntAct=EBI-1047093, EBI-2806068;
CC O76011; Q14773-3: ICAM4; NbExp=3; IntAct=EBI-1047093, EBI-10233928;
CC O76011; Q9NRY2: INIP; NbExp=3; IntAct=EBI-1047093, EBI-2881520;
CC O76011; Q9C086: INO80B; NbExp=3; IntAct=EBI-1047093, EBI-715611;
CC O76011; Q9H1K1: ISCU; NbExp=3; IntAct=EBI-1047093, EBI-1047335;
CC O76011; P18084: ITGB5; NbExp=3; IntAct=EBI-1047093, EBI-1223434;
CC O76011; P27987: ITPKB; NbExp=3; IntAct=EBI-1047093, EBI-751388;
CC O76011; Q15040: JOSD1; NbExp=3; IntAct=EBI-1047093, EBI-2510602;
CC O76011; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-1047093, EBI-2556193;
CC O76011; Q7L273: KCTD9; NbExp=3; IntAct=EBI-1047093, EBI-4397613;
CC O76011; P24390: KDELR1; NbExp=3; IntAct=EBI-1047093, EBI-1043076;
CC O76011; Q9ULH0-2: KIDINS220; NbExp=3; IntAct=EBI-1047093, EBI-11046235;
CC O76011; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-1047093, EBI-949319;
CC O76011; Q2WGJ6: KLHL38; NbExp=5; IntAct=EBI-1047093, EBI-6426443;
CC O76011; O60259: KLK8; NbExp=3; IntAct=EBI-1047093, EBI-3915857;
CC O76011; P04264: KRT1; NbExp=3; IntAct=EBI-1047093, EBI-298429;
CC O76011; P35900: KRT20; NbExp=3; IntAct=EBI-1047093, EBI-742094;
CC O76011; P12035: KRT3; NbExp=5; IntAct=EBI-1047093, EBI-2430095;
CC O76011; P02538: KRT6A; NbExp=3; IntAct=EBI-1047093, EBI-702198;
CC O76011; P48668: KRT6C; NbExp=3; IntAct=EBI-1047093, EBI-2564105;
CC O76011; Q3SY84: KRT71; NbExp=3; IntAct=EBI-1047093, EBI-2952676;
CC O76011; Q7RTS7: KRT74; NbExp=3; IntAct=EBI-1047093, EBI-968660;
CC O76011; O95678: KRT75; NbExp=4; IntAct=EBI-1047093, EBI-2949715;
CC O76011; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-1047093, EBI-1056564;
CC O76011; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-1047093, EBI-2514135;
CC O76011; P05787: KRT8; NbExp=3; IntAct=EBI-1047093, EBI-297852;
CC O76011; Q6KB66-2: KRT80; NbExp=5; IntAct=EBI-1047093, EBI-11999246;
CC O76011; Q14533: KRT81; NbExp=3; IntAct=EBI-1047093, EBI-739648;
CC O76011; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-1047093, EBI-1045341;
CC O76011; P78385: KRT83; NbExp=3; IntAct=EBI-1047093, EBI-10221390;
CC O76011; P78386: KRT85; NbExp=6; IntAct=EBI-1047093, EBI-1049371;
CC O76011; O43790: KRT86; NbExp=3; IntAct=EBI-1047093, EBI-9996498;
CC O76011; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-1047093, EBI-10176379;
CC O76011; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-1047093, EBI-1048945;
CC O76011; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-1047093, EBI-10241353;
CC O76011; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-1047093, EBI-3957672;
CC O76011; P25791-3: LMO2; NbExp=3; IntAct=EBI-1047093, EBI-11959475;
CC O76011; P61968: LMO4; NbExp=5; IntAct=EBI-1047093, EBI-2798728;
CC O76011; Q8WV35: LRRC29; NbExp=3; IntAct=EBI-1047093, EBI-10276755;
CC O76011; Q15345: LRRC41; NbExp=3; IntAct=EBI-1047093, EBI-721408;
CC O76011; Q96S90: LYSMD1; NbExp=3; IntAct=EBI-1047093, EBI-10293291;
CC O76011; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-1047093, EBI-10329546;
CC O76011; Q9Y586: MAB21L2; NbExp=3; IntAct=EBI-1047093, EBI-6659161;
CC O76011; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-1047093, EBI-77889;
CC O76011; P57077-4: MAP3K7CL; NbExp=3; IntAct=EBI-1047093, EBI-10215880;
CC O76011; O60336: MAPKBP1; NbExp=3; IntAct=EBI-1047093, EBI-947402;
CC O76011; P43243: MATR3; NbExp=3; IntAct=EBI-1047093, EBI-352602;
CC O76011; Q8NHZ7: MBD3L2; NbExp=3; IntAct=EBI-1047093, EBI-11989378;
CC O76011; Q9H7H0-2: METTL17; NbExp=3; IntAct=EBI-1047093, EBI-11098807;
CC O76011; Q504T8: MIDN; NbExp=3; IntAct=EBI-1047093, EBI-7153979;
CC O76011; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-1047093, EBI-2801965;
CC O76011; Q13064: MKRN3; NbExp=3; IntAct=EBI-1047093, EBI-2340269;
CC O76011; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-1047093, EBI-743811;
CC O76011; P00540: MOS; NbExp=3; IntAct=EBI-1047093, EBI-1757866;
CC O76011; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-1047093, EBI-10699187;
CC O76011; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-1047093, EBI-744402;
CC O76011; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-1047093, EBI-5662487;
CC O76011; Q15742: NAB2; NbExp=3; IntAct=EBI-1047093, EBI-8641936;
CC O76011; Q8IW45: NAXD; NbExp=3; IntAct=EBI-1047093, EBI-8650724;
CC O76011; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-1047093, EBI-11750983;
CC O76011; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-1047093, EBI-10271199;
CC O76011; P48645: NMU; NbExp=3; IntAct=EBI-1047093, EBI-10210351;
CC O76011; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-1047093, EBI-17490746;
CC O76011; P48146: NPBWR2; NbExp=3; IntAct=EBI-1047093, EBI-10210114;
CC O76011; O15504-2: NUP42; NbExp=3; IntAct=EBI-1047093, EBI-14488689;
CC O76011; Q99572: P2RX7; NbExp=3; IntAct=EBI-1047093, EBI-1753251;
CC O76011; O76083-2: PDE9A; NbExp=5; IntAct=EBI-1047093, EBI-11524542;
CC O76011; P09619: PDGFRB; NbExp=3; IntAct=EBI-1047093, EBI-641237;
CC O76011; Q96LB9: PGLYRP3; NbExp=3; IntAct=EBI-1047093, EBI-12339509;
CC O76011; Q13526: PIN1; NbExp=3; IntAct=EBI-1047093, EBI-714158;
CC O76011; P78337: PITX1; NbExp=3; IntAct=EBI-1047093, EBI-748265;
CC O76011; Q99697-2: PITX2; NbExp=3; IntAct=EBI-1047093, EBI-12138495;
CC O76011; Q16512: PKN1; NbExp=5; IntAct=EBI-1047093, EBI-602382;
CC O76011; Q9Y342: PLLP; NbExp=3; IntAct=EBI-1047093, EBI-3919291;
CC O76011; Q969H6: POP5; NbExp=3; IntAct=EBI-1047093, EBI-366525;
CC O76011; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-1047093, EBI-2557469;
CC O76011; Q86WC6: PPP1R27; NbExp=3; IntAct=EBI-1047093, EBI-5235602;
CC O76011; Q99633: PRPF18; NbExp=3; IntAct=EBI-1047093, EBI-2798416;
CC O76011; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-1047093, EBI-1567797;
CC O76011; A6NJB7-2: PRR19; NbExp=6; IntAct=EBI-1047093, EBI-11998870;
CC O76011; P0CG20: PRR35; NbExp=5; IntAct=EBI-1047093, EBI-11986293;
CC O76011; P25786: PSMA1; NbExp=3; IntAct=EBI-1047093, EBI-359352;
CC O76011; P20618: PSMB1; NbExp=3; IntAct=EBI-1047093, EBI-372273;
CC O76011; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-1047093, EBI-7199479;
CC O76011; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-1047093, EBI-948428;
CC O76011; Q14088: RAB33A; NbExp=3; IntAct=EBI-1047093, EBI-744685;
CC O76011; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-1047093, EBI-743796;
CC O76011; Q9Y272: RASD1; NbExp=3; IntAct=EBI-1047093, EBI-740818;
CC O76011; P40937: RFC5; NbExp=3; IntAct=EBI-1047093, EBI-712376;
CC O76011; Q13671: RIN1; NbExp=3; IntAct=EBI-1047093, EBI-366017;
CC O76011; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-1047093, EBI-10226430;
CC O76011; Q14D33: RTP5; NbExp=3; IntAct=EBI-1047093, EBI-10217913;
CC O76011; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-1047093, EBI-14067109;
CC O76011; Q9BWG6: SCNM1; NbExp=5; IntAct=EBI-1047093, EBI-748391;
CC O76011; Q9UDX3: SEC14L4; NbExp=3; IntAct=EBI-1047093, EBI-10320311;
CC O76011; Q9C0C4: SEMA4C; NbExp=3; IntAct=EBI-1047093, EBI-10303490;
CC O76011; Q92529: SHC3; NbExp=3; IntAct=EBI-1047093, EBI-79084;
CC O76011; Q16348: SLC15A2; NbExp=3; IntAct=EBI-1047093, EBI-12806032;
CC O76011; O76082: SLC22A5; NbExp=3; IntAct=EBI-1047093, EBI-9846338;
CC O76011; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-1047093, EBI-11998660;
CC O76011; Q86VD7: SLC25A42; NbExp=3; IntAct=EBI-1047093, EBI-6598313;
CC O76011; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-1047093, EBI-358489;
CC O76011; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-1047093, EBI-455078;
CC O76011; P49901: SMCP; NbExp=3; IntAct=EBI-1047093, EBI-750494;
CC O76011; Q9H0W8: SMG9; NbExp=5; IntAct=EBI-1047093, EBI-2872322;
CC O76011; P14678-2: SNRPB; NbExp=3; IntAct=EBI-1047093, EBI-372475;
CC O76011; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-1047093, EBI-11959123;
CC O76011; Q5T0L3: SPATA46; NbExp=3; IntAct=EBI-1047093, EBI-750105;
CC O76011; O43610: SPRY3; NbExp=3; IntAct=EBI-1047093, EBI-12290641;
CC O76011; Q9NZ72: STMN3; NbExp=3; IntAct=EBI-1047093, EBI-725557;
CC O76011; P51687: SUOX; NbExp=3; IntAct=EBI-1047093, EBI-3921347;
CC O76011; Q9BSH4: TACO1; NbExp=3; IntAct=EBI-1047093, EBI-747797;
CC O76011; Q9BX59: TAPBPL; NbExp=3; IntAct=EBI-1047093, EBI-12017416;
CC O76011; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-1047093, EBI-8787464;
CC O76011; Q9BT92: TCHP; NbExp=3; IntAct=EBI-1047093, EBI-740781;
CC O76011; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-1047093, EBI-8644516;
CC O76011; Q8WW24: TEKT4; NbExp=5; IntAct=EBI-1047093, EBI-750487;
CC O76011; Q96A09: TENT5B; NbExp=3; IntAct=EBI-1047093, EBI-752030;
CC O76011; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-1047093, EBI-11139477;
CC O76011; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-1047093, EBI-11952651;
CC O76011; Q9BT49: THAP7; NbExp=3; IntAct=EBI-1047093, EBI-741350;
CC O76011; Q08117-2: TLE5; NbExp=3; IntAct=EBI-1047093, EBI-11741437;
CC O76011; O43711: TLX3; NbExp=3; IntAct=EBI-1047093, EBI-3939165;
CC O76011; Q8WUU8: TMEM174; NbExp=3; IntAct=EBI-1047093, EBI-10276729;
CC O76011; P62328: TMSB4X; NbExp=3; IntAct=EBI-1047093, EBI-712598;
CC O76011; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-1047093, EBI-5235829;
CC O76011; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-1047093, EBI-10259086;
CC O76011; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-1047093, EBI-11059915;
CC O76011; Q99816: TSG101; NbExp=5; IntAct=EBI-1047093, EBI-346882;
CC O76011; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-1047093, EBI-9090990;
CC O76011; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-1047093, EBI-2851213;
CC O76011; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-1047093, EBI-11988865;
CC O76011; P40222: TXLNA; NbExp=3; IntAct=EBI-1047093, EBI-359793;
CC O76011; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-1047093, EBI-6116822;
CC O76011; O75604: USP2; NbExp=3; IntAct=EBI-1047093, EBI-743272;
CC O76011; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-1047093, EBI-11737646;
CC O76011; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-1047093, EBI-5457544;
CC O76011; O95231: VENTX; NbExp=4; IntAct=EBI-1047093, EBI-10191303;
CC O76011; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-1047093, EBI-12032042;
CC O76011; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-1047093, EBI-12040603;
CC O76011; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-1047093, EBI-2818796;
CC O76011; Q15911-2: ZFHX3; NbExp=5; IntAct=EBI-1047093, EBI-10237226;
CC O76011; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-1047093, EBI-8656416;
CC O76011; Q15915: ZIC1; NbExp=3; IntAct=EBI-1047093, EBI-11963196;
CC O76011; Q15973: ZNF124; NbExp=3; IntAct=EBI-1047093, EBI-2555767;
CC O76011; Q9UQR1-2: ZNF148; NbExp=3; IntAct=EBI-1047093, EBI-11742222;
CC O76011; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-1047093, EBI-11993110;
CC O76011; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-1047093, EBI-744257;
CC O76011; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-1047093, EBI-740232;
CC O76011; Q9UK33: ZNF580; NbExp=3; IntAct=EBI-1047093, EBI-746277;
CC O76011; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-1047093, EBI-745520;
CC O76011; Q15937: ZNF79; NbExp=3; IntAct=EBI-1047093, EBI-10237274;
CC -!- TISSUE SPECIFICITY: Expressed in the hair follicles.
CC {ECO:0000269|PubMed:9756910}.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-43 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA76386.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y16790; CAA76386.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC033252; AAH33252.1; -; mRNA.
DR EMBL; BC041070; AAH41070.1; -; mRNA.
DR RefSeq; NP_066293.2; NM_021013.3.
DR RefSeq; XP_003403930.1; XM_003403882.4.
DR AlphaFoldDB; O76011; -.
DR SMR; O76011; -.
DR BioGRID; 110083; 275.
DR BioGRID; 1530414; 1.
DR IntAct; O76011; 251.
DR STRING; 9606.ENSP00000377570; -.
DR iPTMnet; O76011; -.
DR PhosphoSitePlus; O76011; -.
DR SwissPalm; O76011; -.
DR BioMuta; KRT34; -.
DR jPOST; O76011; -.
DR MassIVE; O76011; -.
DR PaxDb; O76011; -.
DR PeptideAtlas; O76011; -.
DR PRIDE; O76011; -.
DR ProteomicsDB; 50343; -.
DR Antibodypedia; 28834; 110 antibodies from 26 providers.
DR DNASU; 3885; -.
DR Ensembl; ENST00000394001.3; ENSP00000377570.3; ENSG00000131737.7.
DR GeneID; 100653049; -.
DR GeneID; 3885; -.
DR KEGG; hsa:100653049; -.
DR UCSC; uc002hwm.4; human.
DR CTD; 3885; -.
DR DisGeNET; 3885; -.
DR GeneCards; KRT34; -.
DR HGNC; HGNC:6452; KRT34.
DR HPA; ENSG00000131737; Tissue enriched (skin).
DR MIM; 602763; gene.
DR neXtProt; NX_O76011; -.
DR PharmGKB; PA30241; -.
DR VEuPathDB; HostDB:ENSG00000131737; -.
DR eggNOG; ENOG502RTXS; Eukaryota.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; O76011; -.
DR OMA; CTMPYNC; -.
DR OrthoDB; 772040at2759; -.
DR PhylomeDB; O76011; -.
DR PathwayCommons; O76011; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; O76011; -.
DR BioGRID-ORCS; 100653049; 0 hits in 4 CRISPR screens.
DR BioGRID-ORCS; 3885; 6 hits in 1064 CRISPR screens.
DR GeneWiki; Keratin_34; -.
DR Pharos; O76011; Tbio.
DR PRO; PR:O76011; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O76011; protein.
DR Bgee; ENSG00000131737; Expressed in stromal cell of endometrium and 42 other tissues.
DR Genevisible; O76011; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; NAS:ProtInc.
DR GO; GO:0008544; P:epidermis development; TAS:ProtInc.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..436
FT /note="Keratin, type I cuticular Ha4"
FT /id="PRO_0000063691"
FT DOMAIN 98..409
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..98
FT /note="Head"
FT REGION 99..133
FT /note="Coil 1A"
FT REGION 134..144
FT /note="Linker 1"
FT REGION 145..245
FT /note="Coil 1B"
FT REGION 246..261
FT /note="Linker 12"
FT REGION 262..405
FT /note="Coil 2"
FT REGION 406..436
FT /note="Tail"
FT SITE 347
FT /note="Stutter"
FT VARIANT 280
FT /note="I -> T (in dbSNP:rs2239710)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_056017"
FT VARIANT 348
FT /note="H -> R (in dbSNP:rs2071599)"
FT /id="VAR_056018"
FT CONFLICT 246
FT /note="Q -> P (in Ref. 1; CAA76386)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 49424 MW; EE39CB9622A94CA8 CRC64;
MLYAKPPPTI NGIKGLQRKE RLKPAHIHLQ QLTCFSITCS STMSYSCCLP SLGCRTSCSS
RPCVPPSCHG YTLPGACNIP ANVSNCNWFC EGSFNGSEKE TMQFLNDRLA SYLEKVRQLE
RDNAELEKLI QERSQQQEPL LCPSYQSYFK TIEELQQKIL CAKAENARLV VNIDNAKLAS
DDFRSKYQTE QSLRLLVESD INSIRRILDE LTLCKSDLES QVESLREELI CLKKNHEEEV
NTLRSQLGDR LNVEVDTAPT VDLNQVLNET RSQYEALVEI NRREVEQWFA TQTEELNKQV
VSSSEQLQSC QAEIIELRRT VNALEIELQA QHNLRDSLEN TLTESEAHYS SQLSQVQSLI
TNVESQLAEI RCDLERQNQE YQVLLDVRAR LECEINTYRS LLESEDCKLP CNPCATTNAS
GNSCGPCGTS QKGCCN
