ID   KRT35_BOVIN             Reviewed;         454 AA.
AC   Q0P5J7;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Keratin, type I cuticular Ha5 {ECO:0000250|UniProtKB:Q92764};
DE   AltName: Full=Keratin-35 {ECO:0000312|EMBL:AAI19952.1};
DE            Short=K35;
GN   Name=KRT35 {ECO:0000312|EMBL:AAI19952.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2] {ECO:0000312|EMBL:AAI19952.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI19952.1};
RC   TISSUE=Fetal skin {ECO:0000312|EMBL:AAI19952.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC       (acidic) and II (neutral to basic). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI19952.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AAFC03004241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03085602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC119951; AAI19952.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001069541.1; NM_001076073.1.
DR   AlphaFoldDB; Q0P5J7; -.
DR   SMR; Q0P5J7; -.
DR   STRING; 9913.ENSBTAP00000040659; -.
DR   PRIDE; Q0P5J7; -.
DR   GeneID; 536311; -.
DR   KEGG; bta:536311; -.
DR   CTD; 3886; -.
DR   eggNOG; ENOG502QQY9; Eukaryota.
DR   HOGENOM; CLU_012560_8_0_1; -.
DR   InParanoid; Q0P5J7; -.
DR   OrthoDB; 798081at2759; -.
DR   TreeFam; TF332742; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..454
FT                   /note="Keratin, type I cuticular Ha5"
FT                   /id="PRO_0000361024"
FT   DOMAIN          97..407
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..97
FT                   /note="Head"
FT                   /evidence="ECO:0000255"
FT   REGION          98..125
FT                   /note="Coil 1A"
FT   REGION          134..142
FT                   /note="Linker 1"
FT   REGION          143..243
FT                   /note="Coil 1B"
FT   REGION          244..259
FT                   /note="Linker 12"
FT   REGION          260..403
FT                   /note="Coil 2"
FT   REGION          404..454
FT                   /note="Tail"
FT   SITE            345
FT                   /note="Stutter"
FT   CONFLICT        82
FT                   /note="S -> G (in Ref. 2; AAI19952)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   454 AA;  49937 MW;  C13533324192E30D CRC64;
     MASKCLKASF SSGSLKVPGG AGGGSARVST IFSSSSCKLP SFSRGPRSFS ACSVGLGKSS
     CRAASCLPAL CLPSGGFATS YSMAGGWFGE GILTGNEKET MQFLNDRLAS YLEKCGSWSG
     RTRSWRAAST SGVSNSALPV PDYQSYFQTI EELQKKTLCT KSENARLVVQ IDNAKLAADD
     FRTKYETEVS MRQLVESDMN GLRRILDDLT LCKADLEAQV ESLKEELLCL KKNHEEEVNS
     LRCQLGDRLN VEVDAAPPVD LNRVLNEMRC QYETLVENNR REAEDWFNTQ TEELNQQVVS
     SSEQLQSYQA EIIELRRTVN ALEIELQAQH SMRDALESTL AETEARYSSQ LAQMQGLIGN
     VESQLAEIRC DLERQNQEYQ VLLDVRARLE CEINTYRGLL DSEDCKLPCN PCAPDHSPSK
     SCLPCLPAAS CGPGMARTTC SPRPICVPCP GSRF