KRT35_HUMAN
ID KRT35_HUMAN Reviewed; 455 AA.
AC Q92764; O76012; Q92651;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 5.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Keratin, type I cuticular Ha5;
DE AltName: Full=Hair keratin, type I Ha5;
DE AltName: Full=Keratin-35;
DE Short=K35;
GN Name=KRT35; Synonyms=HHA5, HKA5, KRTHA5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-455,
RP TISSUE SPECIFICITY, AND VARIANTS PRO-36 AND ALA-443.
RC TISSUE=Hair, and Scalp;
RX PubMed=8823373; DOI=10.1111/1523-1747.ep12584243;
RA Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J.;
RT "Genomic characterization of the human type I cuticular hair keratin hHa2
RT and identification of an adjacent novel type I hair keratin gene hHa5.";
RL J. Invest. Dermatol. 107:633-638(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT "Characterization of a 190-kilobase pair domain of human type I hair
RT keratin genes.";
RL J. Biol. Chem. 273:26683-26691(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- INTERACTION:
CC Q92764; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-1058674, EBI-742038;
CC Q92764; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-1058674, EBI-12006308;
CC Q92764; O75934: BCAS2; NbExp=3; IntAct=EBI-1058674, EBI-1050106;
CC Q92764; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-1058674, EBI-8643161;
CC Q92764; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-1058674, EBI-10226774;
CC Q92764; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-1058674, EBI-744556;
CC Q92764; Q8N715: CCDC185; NbExp=3; IntAct=EBI-1058674, EBI-740814;
CC Q92764; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-1058674, EBI-10181422;
CC Q92764; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-1058674, EBI-10175300;
CC Q92764; P20138: CD33; NbExp=3; IntAct=EBI-1058674, EBI-3906571;
CC Q92764; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-1058674, EBI-8636823;
CC Q92764; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-1058674, EBI-9679045;
CC Q92764; O60941-5: DTNB; NbExp=3; IntAct=EBI-1058674, EBI-11984733;
CC Q92764; Q8N7B9-2: EFCAB3; NbExp=3; IntAct=EBI-1058674, EBI-11958551;
CC Q92764; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-1058674, EBI-744099;
CC Q92764; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-1058674, EBI-371876;
CC Q92764; A6H8Z2: FAM221B; NbExp=3; IntAct=EBI-1058674, EBI-12006844;
CC Q92764; O43559: FRS3; NbExp=3; IntAct=EBI-1058674, EBI-725515;
CC Q92764; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-1058674, EBI-11956675;
CC Q92764; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-1058674, EBI-14103818;
CC Q92764; P08631-2: HCK; NbExp=3; IntAct=EBI-1058674, EBI-9834454;
CC Q92764; P56524-2: HDAC4; NbExp=3; IntAct=EBI-1058674, EBI-11953488;
CC Q92764; O14964: HGS; NbExp=3; IntAct=EBI-1058674, EBI-740220;
CC Q92764; P49639: HOXA1; NbExp=3; IntAct=EBI-1058674, EBI-740785;
CC Q92764; P31273: HOXC8; NbExp=3; IntAct=EBI-1058674, EBI-1752118;
CC Q92764; Q7L273: KCTD9; NbExp=3; IntAct=EBI-1058674, EBI-4397613;
CC Q92764; O60341: KDM1A; NbExp=3; IntAct=EBI-1058674, EBI-710124;
CC Q92764; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-1058674, EBI-14069005;
CC Q92764; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-1058674, EBI-6426443;
CC Q92764; P04264: KRT1; NbExp=3; IntAct=EBI-1058674, EBI-298429;
CC Q92764; P35908: KRT2; NbExp=3; IntAct=EBI-1058674, EBI-1247312;
CC Q92764; P12035: KRT3; NbExp=3; IntAct=EBI-1058674, EBI-2430095;
CC Q92764; P19013: KRT4; NbExp=3; IntAct=EBI-1058674, EBI-2371606;
CC Q92764; P13647: KRT5; NbExp=3; IntAct=EBI-1058674, EBI-702187;
CC Q92764; P02538: KRT6A; NbExp=3; IntAct=EBI-1058674, EBI-702198;
CC Q92764; P04259: KRT6B; NbExp=3; IntAct=EBI-1058674, EBI-740907;
CC Q92764; P48668: KRT6C; NbExp=3; IntAct=EBI-1058674, EBI-2564105;
CC Q92764; Q3SY84: KRT71; NbExp=3; IntAct=EBI-1058674, EBI-2952676;
CC Q92764; Q14CN4: KRT72; NbExp=3; IntAct=EBI-1058674, EBI-1221280;
CC Q92764; Q7RTS7: KRT74; NbExp=3; IntAct=EBI-1058674, EBI-968660;
CC Q92764; O95678: KRT75; NbExp=3; IntAct=EBI-1058674, EBI-2949715;
CC Q92764; Q7Z794: KRT77; NbExp=3; IntAct=EBI-1058674, EBI-3045529;
CC Q92764; Q8N1N4: KRT78; NbExp=5; IntAct=EBI-1058674, EBI-1056564;
CC Q92764; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-1058674, EBI-2514135;
CC Q92764; P05787: KRT8; NbExp=3; IntAct=EBI-1058674, EBI-297852;
CC Q92764; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-1058674, EBI-11999246;
CC Q92764; Q14533: KRT81; NbExp=3; IntAct=EBI-1058674, EBI-739648;
CC Q92764; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-1058674, EBI-1045341;
CC Q92764; P78385: KRT83; NbExp=3; IntAct=EBI-1058674, EBI-10221390;
CC Q92764; P78386: KRT85; NbExp=3; IntAct=EBI-1058674, EBI-1049371;
CC Q92764; O43790: KRT86; NbExp=3; IntAct=EBI-1058674, EBI-9996498;
CC Q92764; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-1058674, EBI-726510;
CC Q92764; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-1058674, EBI-10274069;
CC Q92764; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-1058674, EBI-2341787;
CC Q92764; O60336: MAPKBP1; NbExp=3; IntAct=EBI-1058674, EBI-947402;
CC Q92764; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-1058674, EBI-348259;
CC Q92764; O43482: OIP5; NbExp=3; IntAct=EBI-1058674, EBI-536879;
CC Q92764; P32242: OTX1; NbExp=3; IntAct=EBI-1058674, EBI-740446;
CC Q92764; Q16512: PKN1; NbExp=3; IntAct=EBI-1058674, EBI-602382;
CC Q92764; Q12837: POU4F2; NbExp=3; IntAct=EBI-1058674, EBI-17236143;
CC Q92764; Q99633: PRPF18; NbExp=3; IntAct=EBI-1058674, EBI-2798416;
CC Q92764; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-1058674, EBI-1567797;
CC Q92764; P0CG20: PRR35; NbExp=3; IntAct=EBI-1058674, EBI-11986293;
CC Q92764; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-1058674, EBI-11984663;
CC Q92764; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-1058674, EBI-748391;
CC Q92764; Q92529: SHC3; NbExp=3; IntAct=EBI-1058674, EBI-79084;
CC Q92764; Q8N370: SLC43A2; NbExp=3; IntAct=EBI-1058674, EBI-10265149;
CC Q92764; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-1058674, EBI-455078;
CC Q92764; Q8NB12: SMYD1; NbExp=3; IntAct=EBI-1058674, EBI-8463848;
CC Q92764; Q9BX59: TAPBPL; NbExp=3; IntAct=EBI-1058674, EBI-12017416;
CC Q92764; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-1058674, EBI-12018146;
CC Q92764; Q9Y2I9-2: TBC1D30; NbExp=3; IntAct=EBI-1058674, EBI-17455779;
CC Q92764; Q9P0N9: TBC1D7; NbExp=3; IntAct=EBI-1058674, EBI-3258000;
CC Q92764; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-1058674, EBI-11955057;
CC Q92764; Q9BT92: TCHP; NbExp=3; IntAct=EBI-1058674, EBI-740781;
CC Q92764; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-1058674, EBI-750487;
CC Q92764; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-1058674, EBI-11139477;
CC Q92764; Q08117-2: TLE5; NbExp=3; IntAct=EBI-1058674, EBI-11741437;
CC Q92764; Q14134: TRIM29; NbExp=3; IntAct=EBI-1058674, EBI-702370;
CC Q92764; Q99816: TSG101; NbExp=3; IntAct=EBI-1058674, EBI-346882;
CC Q92764; P40222: TXLNA; NbExp=3; IntAct=EBI-1058674, EBI-359793;
CC Q92764; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-1058674, EBI-6116822;
CC Q92764; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-1058674, EBI-7353612;
CC Q92764; O75604: USP2; NbExp=3; IntAct=EBI-1058674, EBI-743272;
CC Q92764; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-1058674, EBI-9031083;
CC Q92764; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-1058674, EBI-740727;
CC Q92764; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-1058674, EBI-740232;
CC -!- TISSUE SPECIFICITY: Early expression in the hair follicle, mainly found
CC in supramatricial cells and lowermost cortical cells of the hair bulb.
CC {ECO:0000269|PubMed:8823373}.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA62286.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA76387.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X90762; CAA62285.1; -; Genomic_DNA.
DR EMBL; X90763; CAA62286.1; ALT_INIT; mRNA.
DR EMBL; Y16791; CAA76387.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC019349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS11394.2; -.
DR RefSeq; NP_002271.3; NM_002280.4.
DR RefSeq; XP_011523096.1; XM_011524794.1.
DR AlphaFoldDB; Q92764; -.
DR SMR; Q92764; -.
DR BioGRID; 110084; 189.
DR IntAct; Q92764; 91.
DR STRING; 9606.ENSP00000377558; -.
DR iPTMnet; Q92764; -.
DR MetOSite; Q92764; -.
DR PhosphoSitePlus; Q92764; -.
DR BioMuta; KRT35; -.
DR DMDM; 296439499; -.
DR jPOST; Q92764; -.
DR MassIVE; Q92764; -.
DR PaxDb; Q92764; -.
DR PeptideAtlas; Q92764; -.
DR PRIDE; Q92764; -.
DR ProteomicsDB; 75448; -.
DR Antibodypedia; 28853; 153 antibodies from 21 providers.
DR DNASU; 3886; -.
DR Ensembl; ENST00000246639.7; ENSP00000246639.3; ENSG00000197079.9.
DR GeneID; 3886; -.
DR KEGG; hsa:3886; -.
DR MANE-Select; ENST00000246639.7; ENSP00000246639.3; NM_002280.6; NP_002271.3.
DR UCSC; uc002hws.4; human.
DR CTD; 3886; -.
DR DisGeNET; 3886; -.
DR GeneCards; KRT35; -.
DR HGNC; HGNC:6453; KRT35.
DR HPA; ENSG00000197079; Tissue enriched (skin).
DR MIM; 602764; gene.
DR neXtProt; NX_Q92764; -.
DR OpenTargets; ENSG00000197079; -.
DR PharmGKB; PA30242; -.
DR VEuPathDB; HostDB:ENSG00000197079; -.
DR eggNOG; ENOG502QQY9; Eukaryota.
DR GeneTree; ENSGT00940000161787; -.
DR InParanoid; Q92764; -.
DR OMA; LNIEVDC; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q92764; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; Q92764; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q92764; -.
DR BioGRID-ORCS; 3886; 13 hits in 1031 CRISPR screens.
DR GenomeRNAi; 3886; -.
DR Pharos; Q92764; Tbio.
DR PRO; PR:Q92764; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q92764; protein.
DR Bgee; ENSG00000197079; Expressed in upper arm skin and 55 other tissues.
DR ExpressionAtlas; Q92764; baseline and differential.
DR Genevisible; Q92764; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..455
FT /note="Keratin, type I cuticular Ha5"
FT /id="PRO_0000063692"
FT DOMAIN 97..408
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..97
FT /note="Head"
FT REGION 98..132
FT /note="Coil 1A"
FT REGION 133..143
FT /note="Linker 1"
FT REGION 144..244
FT /note="Coil 1B"
FT REGION 245..260
FT /note="Linker 12"
FT REGION 261..404
FT /note="Coil 2"
FT REGION 405..455
FT /note="Tail"
FT SITE 346
FT /note="Stutter"
FT VARIANT 36
FT /note="S -> P (in dbSNP:rs743686)"
FT /evidence="ECO:0000269|PubMed:8823373"
FT /id="VAR_056019"
FT VARIANT 441
FT /note="C -> Y (in dbSNP:rs12451652)"
FT /id="VAR_056020"
FT VARIANT 443
FT /note="P -> A (in dbSNP:rs2071601)"
FT /evidence="ECO:0000269|PubMed:8823373"
FT /id="VAR_056021"
FT CONFLICT 117..118
FT /note="QL -> HV (in Ref. 1; CAA62286 and 2; CAA76387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 455 AA; 50361 MW; 3E72080469C8E80B CRC64;
MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS ACSVGLGRSS
YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET MQSLNDRLAG YLEKVRQLEQ
ENASLESRIR EWCEQQVPYM CPDYQSYFRT IEELQKKTLC SKAENARLVV EIDNAKLAAD
DFRTKYETEV SLRQLVESDI NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN
SLRCQLGDRL NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV
SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQCMIT
NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSPS
KSCLPCLPAA SCGPSAARTN CSPRPICVPC PGGRF
