KRT35_MOUSE
ID KRT35_MOUSE Reviewed; 455 AA.
AC Q497I4; B2RU48; Q9Z2T8;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Keratin, type I cuticular Ha5 {ECO:0000250|UniProtKB:Q92764};
DE AltName: Full=Hair keratin, type I Ha5;
DE AltName: Full=Keratin-35 {ECO:0000250|UniProtKB:Q92764, ECO:0000312|EMBL:CAM15793.1};
DE Short=K35;
GN Name=Krt35 {ECO:0000312|MGI:MGI:1858899};
GN Synonyms=Krt1-24 {ECO:0000312|MGI:MGI:1858899};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAD01693.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR {ECO:0000312|EMBL:AAD01693.1};
RC TISSUE=Skin {ECO:0000312|EMBL:AAD01693.1};
RA Inoue T., Kizawa K.;
RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAI00543.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD01693.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI40966.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF020790; AAD01693.1; ALT_INIT; mRNA.
DR EMBL; AL662808; CAM15793.1; -; Genomic_DNA.
DR EMBL; BC100542; AAI00543.1; -; mRNA.
DR EMBL; BC140965; AAI40966.1; ALT_INIT; mRNA.
DR CCDS; CCDS25407.2; -.
DR RefSeq; NP_058576.2; NM_016880.2.
DR AlphaFoldDB; Q497I4; -.
DR SMR; Q497I4; -.
DR BioGRID; 207334; 5.
DR STRING; 10090.ENSMUSP00000099416; -.
DR iPTMnet; Q497I4; -.
DR PhosphoSitePlus; Q497I4; -.
DR jPOST; Q497I4; -.
DR PaxDb; Q497I4; -.
DR PeptideAtlas; Q497I4; -.
DR PRIDE; Q497I4; -.
DR ProteomicsDB; 264871; -.
DR Antibodypedia; 28853; 153 antibodies from 21 providers.
DR DNASU; 53617; -.
DR Ensembl; ENSMUST00000103127; ENSMUSP00000099416; ENSMUSG00000048013.
DR GeneID; 53617; -.
DR KEGG; mmu:53617; -.
DR UCSC; uc011yex.1; mouse.
DR CTD; 3886; -.
DR MGI; MGI:1858899; Krt35.
DR VEuPathDB; HostDB:ENSMUSG00000048013; -.
DR eggNOG; ENOG502QQY9; Eukaryota.
DR GeneTree; ENSGT00940000161787; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q497I4; -.
DR OMA; LNIEVDC; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q497I4; -.
DR TreeFam; TF332742; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 53617; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q497I4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q497I4; protein.
DR Bgee; ENSMUSG00000048013; Expressed in hair follicle and 21 other tissues.
DR Genevisible; Q497I4; MM.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..455
FT /note="Keratin, type I cuticular Ha5"
FT /id="PRO_0000361025"
FT DOMAIN 97..408
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..97
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 98..132
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 133..143
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 144..244
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 245..260
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 261..404
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 405..455
FT /note="Tail"
FT /evidence="ECO:0000255"
FT SITE 316
FT /note="Stutter"
FT /evidence="ECO:0000255"
FT CONFLICT 429
FT /note="A -> V (in Ref. 1; AAD01693 and 3; AAI40966)"
FT /evidence="ECO:0000305"
FT CONFLICT 437
FT /note="A -> R (in Ref. 1; AAD01693)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 455 AA; 50530 MW; 5C7AEC2D58472CD7 CRC64;
MASKCLKASF SSGSLKSPGK AGGGSTRVSN MYSSSSCKLP SPSRGARSFS VCSAGLGRGN
YRVSSCLPAL CLPTGGFATS YGTGGGWFGE GILTGNEKET MQSLNDRLAS YLEKVRQLEQ
ENASLESRIR EWCEQQVPYM CPDYQSYFRT MEELQKKTLC SKAENARLVV QIDNAKLAAD
DFRTKYETEV SLRQLVEADI NGLRRILDDL TLCKADLEAQ VESLKEELLC LKKNHEEEVN
SLRCQLGDRL NVEVDAAPPV DLNRVLDEMR CQYETLVENN RRDAEDWYDT QTEELNQQVV
SSSEQLQSCQ SDIIELRRTV NSLEIELQAQ QSMRDALDST LAETEGRYSS QLAQMQCMIG
NVESQLGEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSSS
KSCLPCLPAV SCSTGAARTT CSPRPVCVPC PGGRF
