ID   KRT35_SHEEP             Reviewed;         455 AA.
AC   B0LKP1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Keratin, type I cuticular Ha5 {ECO:0000250|UniProtKB:Q92764};
DE   AltName: Full=Keratin-35 {ECO:0000312|EMBL:ABY64914.1};
DE            Short=K35;
GN   Name=KRT35 {ECO:0000250|UniProtKB:Q92764};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1] {ECO:0000312|EMBL:ABY64914.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yu Z., Gordon S.W., Nixon A.J., Bawden C.S., Rogers M.A., Wildermoth J.E.,
RA   Maqbool N.J., Pearson A.J.;
RT   "Temporal and spatial expression patterns of keratin intermediate filament
RT   (KIF) protein and keratin associated protein (KAP) genes in wool
RT   follicles.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC       (acidic) and II (neutral to basic). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; EU216426; ABY64914.1; -; mRNA.
DR   RefSeq; NP_001108233.1; NM_001114761.1.
DR   AlphaFoldDB; B0LKP1; -.
DR   SMR; B0LKP1; -.
DR   STRING; 9940.ENSOARP00000018025; -.
DR   PRIDE; B0LKP1; -.
DR   GeneID; 100141296; -.
DR   KEGG; oas:100141296; -.
DR   CTD; 3886; -.
DR   eggNOG; ENOG502QQY9; Eukaryota.
DR   OrthoDB; 798081at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..455
FT                   /note="Keratin, type I cuticular Ha5"
FT                   /id="PRO_0000361026"
FT   DOMAIN          97..408
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..97
FT                   /note="Head"
FT                   /evidence="ECO:0000255"
FT   REGION          98..132
FT                   /note="Coil 1A"
FT                   /evidence="ECO:0000255"
FT   REGION          133..143
FT                   /note="Linker 1"
FT                   /evidence="ECO:0000255"
FT   REGION          144..244
FT                   /note="Coil 1B"
FT                   /evidence="ECO:0000255"
FT   REGION          245..260
FT                   /note="Linker 12"
FT                   /evidence="ECO:0000255"
FT   REGION          261..404
FT                   /note="Coil 2"
FT                   /evidence="ECO:0000255"
FT   REGION          405..455
FT                   /note="Tail"
FT                   /evidence="ECO:0000255"
FT   SITE            346
FT                   /note="Stutter"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   455 AA;  50456 MW;  75493708A49F4A9A CRC64;
     MASKCLKASF SSGSLKVPGG AGGGSARVST IFSSSSCKLS GLSRGPRSFS ACSVGLGKSS
     CRAASCLPAL CLPSGGFATS YGMAGGWFGE GILTGNEKET MQFLNDRLAS YLEKVRQLER
     ENAELESRIR DWCEQQVPYL CPDYQSYFQT IEELQKKILC TKSENARLVV QIDNAKLAAD
     DFRTKYETEV TMRQLVESDM NGLRRILDDL TLCKADLEAQ VESLKEELLC LKKNHEEEVN
     SLRCQLGDRL NVEVDAAPPV DLNRVLNEMR CQYETLVENN RREAEDWFNT QTEELNQQVV
     SSSEQLQSYQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQGLIG
     NVESQLAEIR CDLERQNQEY QVLLDVRARL ECEISTYRGL LDSEDCKLPC NPCAPDHSPS
     KSCLPCLPAA SCGPGTAHTT CSPRPICVSC PGSRF