KRT36_HUMAN
ID KRT36_HUMAN Reviewed; 467 AA.
AC O76013; Q86XG4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Keratin, type I cuticular Ha6;
DE AltName: Full=Hair keratin, type I Ha6;
DE AltName: Full=Keratin-36;
DE Short=K36;
GN Name=KRT36; Synonyms=HHA6, HKA6, KRTHA6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), AND
RP TISSUE SPECIFICITY.
RX PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT "Characterization of a 190-kilobase pair domain of human type I hair
RT keratin genes.";
RL J. Biol. Chem. 273:26683-26691(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC O76013-2; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-11958506, EBI-11096309;
CC O76013-2; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-11958506, EBI-742038;
CC O76013-2; Q13155: AIMP2; NbExp=3; IntAct=EBI-11958506, EBI-745226;
CC O76013-2; A2BDD9: AMOT; NbExp=3; IntAct=EBI-11958506, EBI-17286414;
CC O76013-2; O75934: BCAS2; NbExp=3; IntAct=EBI-11958506, EBI-1050106;
CC O76013-2; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-11958506, EBI-747505;
CC O76013-2; Q6UXH8-3: CCBE1; NbExp=3; IntAct=EBI-11958506, EBI-12013534;
CC O76013-2; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-11958506, EBI-10175300;
CC O76013-2; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-11958506, EBI-396137;
CC O76013-2; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11958506, EBI-9679045;
CC O76013-2; Q8IYI6: EXOC8; NbExp=4; IntAct=EBI-11958506, EBI-742102;
CC O76013-2; P55040: GEM; NbExp=3; IntAct=EBI-11958506, EBI-744104;
CC O76013-2; Q13227: GPS2; NbExp=3; IntAct=EBI-11958506, EBI-713355;
CC O76013-2; P08631-2: HCK; NbExp=3; IntAct=EBI-11958506, EBI-9834454;
CC O76013-2; O14964: HGS; NbExp=3; IntAct=EBI-11958506, EBI-740220;
CC O76013-2; P31273: HOXC8; NbExp=3; IntAct=EBI-11958506, EBI-1752118;
CC O76013-2; P04264: KRT1; NbExp=3; IntAct=EBI-11958506, EBI-298429;
CC O76013-2; P35908: KRT2; NbExp=3; IntAct=EBI-11958506, EBI-1247312;
CC O76013-2; P12035: KRT3; NbExp=5; IntAct=EBI-11958506, EBI-2430095;
CC O76013-2; P19013: KRT4; NbExp=5; IntAct=EBI-11958506, EBI-2371606;
CC O76013-2; P02538: KRT6A; NbExp=3; IntAct=EBI-11958506, EBI-702198;
CC O76013-2; P48668: KRT6C; NbExp=3; IntAct=EBI-11958506, EBI-2564105;
CC O76013-2; Q86Y46-2: KRT73; NbExp=3; IntAct=EBI-11958506, EBI-12039441;
CC O76013-2; O95678: KRT75; NbExp=5; IntAct=EBI-11958506, EBI-2949715;
CC O76013-2; Q01546: KRT76; NbExp=3; IntAct=EBI-11958506, EBI-2952745;
CC O76013-2; Q7Z794: KRT77; NbExp=3; IntAct=EBI-11958506, EBI-3045529;
CC O76013-2; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-11958506, EBI-1056564;
CC O76013-2; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-11958506, EBI-2514135;
CC O76013-2; P05787: KRT8; NbExp=3; IntAct=EBI-11958506, EBI-297852;
CC O76013-2; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-11958506, EBI-11999246;
CC O76013-2; P78386: KRT85; NbExp=3; IntAct=EBI-11958506, EBI-1049371;
CC O76013-2; O43790: KRT86; NbExp=5; IntAct=EBI-11958506, EBI-9996498;
CC O76013-2; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-11958506, EBI-744402;
CC O76013-2; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-11958506, EBI-5662487;
CC O76013-2; Q16512: PKN1; NbExp=3; IntAct=EBI-11958506, EBI-602382;
CC O76013-2; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-11958506, EBI-12014286;
CC O76013-2; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-11958506, EBI-2557469;
CC O76013-2; P20618: PSMB1; NbExp=3; IntAct=EBI-11958506, EBI-372273;
CC O76013-2; P47897: QARS1; NbExp=3; IntAct=EBI-11958506, EBI-347462;
CC O76013-2; Q9HCM1: RESF1; NbExp=3; IntAct=EBI-11958506, EBI-308368;
CC O76013-2; Q8N443: RIBC1; NbExp=3; IntAct=EBI-11958506, EBI-10265323;
CC O76013-2; P62328: TMSB4X; NbExp=3; IntAct=EBI-11958506, EBI-712598;
CC O76013-2; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-11958506, EBI-3650647;
CC O76013-2; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11958506, EBI-10241197;
CC O76013-2; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-11958506, EBI-9090990;
CC O76013-2; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-11958506, EBI-11979997;
CC O76013-2; P40222: TXLNA; NbExp=3; IntAct=EBI-11958506, EBI-359793;
CC O76013-2; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-11958506, EBI-744257;
CC O76013-2; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-11958506, EBI-3925400;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O76013-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O76013-2; Sequence=VSP_036403;
CC -!- TISSUE SPECIFICITY: Expressed in the hair follicles.
CC {ECO:0000269|PubMed:9756910}.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; Y16792; CAA76388.1; -; Genomic_DNA.
DR EMBL; CH471152; EAW60738.1; -; Genomic_DNA.
DR EMBL; BC043581; AAH43581.1; -; mRNA.
DR CCDS; CCDS11395.1; -. [O76013-1]
DR RefSeq; NP_003762.1; NM_003771.4. [O76013-1]
DR AlphaFoldDB; O76013; -.
DR SMR; O76013; -.
DR BioGRID; 114236; 61.
DR ComplexPortal; CPX-5663; Keratin-36 - Keratin-86 dimer complex.
DR IntAct; O76013; 63.
DR STRING; 9606.ENSP00000329165; -.
DR CarbonylDB; O76013; -.
DR iPTMnet; O76013; -.
DR PhosphoSitePlus; O76013; -.
DR BioMuta; KRT36; -.
DR jPOST; O76013; -.
DR MassIVE; O76013; -.
DR PaxDb; O76013; -.
DR PeptideAtlas; O76013; -.
DR PRIDE; O76013; -.
DR ProteomicsDB; 50344; -. [O76013-1]
DR ProteomicsDB; 50345; -. [O76013-2]
DR Antibodypedia; 16678; 139 antibodies from 26 providers.
DR DNASU; 8689; -.
DR Ensembl; ENST00000328119.11; ENSP00000329165.6; ENSG00000126337.14. [O76013-1]
DR Ensembl; ENST00000393986.2; ENSP00000377555.2; ENSG00000126337.14. [O76013-2]
DR GeneID; 8689; -.
DR KEGG; hsa:8689; -.
DR MANE-Select; ENST00000328119.11; ENSP00000329165.6; NM_003771.5; NP_003762.1.
DR UCSC; uc002hwt.3; human. [O76013-1]
DR CTD; 8689; -.
DR DisGeNET; 8689; -.
DR GeneCards; KRT36; -.
DR HGNC; HGNC:6454; KRT36.
DR HPA; ENSG00000126337; Group enriched (lymphoid tissue, skin).
DR MIM; 604540; gene.
DR neXtProt; NX_O76013; -.
DR OpenTargets; ENSG00000126337; -.
DR PharmGKB; PA30243; -.
DR VEuPathDB; HostDB:ENSG00000126337; -.
DR eggNOG; ENOG502QQY9; Eukaryota.
DR GeneTree; ENSGT00940000161311; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; O76013; -.
DR OMA; AHPCSTE; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; O76013; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; O76013; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; O76013; -.
DR BioGRID-ORCS; 8689; 9 hits in 1064 CRISPR screens.
DR GeneWiki; KRT36; -.
DR GenomeRNAi; 8689; -.
DR Pharos; O76013; Tdark.
DR PRO; PR:O76013; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O76013; protein.
DR Bgee; ENSG00000126337; Expressed in body of tongue and 37 other tissues.
DR Genevisible; O76013; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IBA:GO_Central.
DR GO; GO:0045095; C:keratin filament; IPI:ComplexPortal.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0045616; P:regulation of keratinocyte differentiation; IEA:Ensembl.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Intermediate filament; Keratin;
KW Reference proteome.
FT CHAIN 1..467
FT /note="Keratin, type I cuticular Ha6"
FT /id="PRO_0000063693"
FT DOMAIN 93..404
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..93
FT /note="Head"
FT REGION 94..128
FT /note="Coil 1A"
FT REGION 129..139
FT /note="Linker 1"
FT REGION 140..240
FT /note="Coil 1B"
FT REGION 241..256
FT /note="Linker 12"
FT REGION 257..400
FT /note="Coil 2"
FT REGION 401..467
FT /note="Tail"
FT SITE 342
FT /note="Stutter"
FT VAR_SEQ 1..52
FT /note="MATQTCTPTFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSA
FT -> ML (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036403"
FT VARIANT 119
FT /note="A -> V (in dbSNP:rs8082683)"
FT /id="VAR_024490"
FT VARIANT 126
FT /note="Q -> R (in dbSNP:rs8069943)"
FT /id="VAR_024491"
FT VARIANT 179
FT /note="R -> Q (in dbSNP:rs9675246)"
FT /id="VAR_049792"
FT VARIANT 277
FT /note="R -> C (in dbSNP:rs9904102)"
FT /id="VAR_049793"
FT VARIANT 315
FT /note="T -> M (in dbSNP:rs2301354)"
FT /id="VAR_020306"
FT VARIANT 357
FT /note="N -> T (in dbSNP:rs11657323)"
FT /id="VAR_049794"
SQ SEQUENCE 467 AA; 52247 MW; 492B3B2DE3BCAECD CRC64;
MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS SARSGLSGLG
SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL NDRLANYLEK VRQLERENAE
LESRIQEWYE FQIPYICPDY QSYFKTIEDF QQKILLTKSE NARLVLQIDN AKLAADDFRT
KYETELSLRQ LVEADINGLR RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC
QLGDRLNVEV DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE
QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ MQCLISNVEA
QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE DCKLPPQPCA TACKPVIRVP
SVPPVPCVPS VPCTPAPQVG TQIRTITEEI RDGKVISSRE HVQSRPL
