KRT37_HUMAN
ID KRT37_HUMAN Reviewed; 449 AA.
AC O76014;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Keratin, type I cuticular Ha7;
DE AltName: Full=Hair keratin, type I Ha7;
DE AltName: Full=Keratin-37;
DE Short=K37;
GN Name=KRT37; Synonyms=HHA7, HKA7, KRTHA7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT "Characterization of a 190-kilobase pair domain of human type I hair
RT keratin genes.";
RL J. Biol. Chem. 273:26683-26691(1998).
RN [2]
RP SEQUENCE REVISION.
RA Schweizer J.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC O76014; P21549: AGXT; NbExp=3; IntAct=EBI-1045716, EBI-727098;
CC O76014; P29972: AQP1; NbExp=3; IntAct=EBI-1045716, EBI-745213;
CC O76014; O75934: BCAS2; NbExp=3; IntAct=EBI-1045716, EBI-1050106;
CC O76014; Q13515: BFSP2; NbExp=3; IntAct=EBI-1045716, EBI-10229433;
CC O76014; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-1045716, EBI-10226774;
CC O76014; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-1045716, EBI-10181422;
CC O76014; P51800-3: CLCNKA; NbExp=3; IntAct=EBI-1045716, EBI-11980535;
CC O76014; P27658: COL8A1; NbExp=3; IntAct=EBI-1045716, EBI-747133;
CC O76014; P17661: DES; NbExp=3; IntAct=EBI-1045716, EBI-1055572;
CC O76014; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-1045716, EBI-1752811;
CC O76014; Q969U6: FBXW5; NbExp=3; IntAct=EBI-1045716, EBI-741068;
CC O76014; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-1045716, EBI-11427343;
CC O76014; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-1045716, EBI-11956675;
CC O76014; O14964: HGS; NbExp=3; IntAct=EBI-1045716, EBI-740220;
CC O76014; P49639: HOXA1; NbExp=3; IntAct=EBI-1045716, EBI-740785;
CC O76014; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-1045716, EBI-12056251;
CC O76014; P04264: KRT1; NbExp=3; IntAct=EBI-1045716, EBI-298429;
CC O76014; P12035: KRT3; NbExp=3; IntAct=EBI-1045716, EBI-2430095;
CC O76014; P19013: KRT4; NbExp=3; IntAct=EBI-1045716, EBI-2371606;
CC O76014; P04259: KRT6B; NbExp=3; IntAct=EBI-1045716, EBI-740907;
CC O76014; P48668: KRT6C; NbExp=3; IntAct=EBI-1045716, EBI-2564105;
CC O76014; Q3SY84: KRT71; NbExp=3; IntAct=EBI-1045716, EBI-2952676;
CC O76014; Q7RTS7: KRT74; NbExp=7; IntAct=EBI-1045716, EBI-968660;
CC O76014; O95678: KRT75; NbExp=3; IntAct=EBI-1045716, EBI-2949715;
CC O76014; Q01546: KRT76; NbExp=3; IntAct=EBI-1045716, EBI-2952745;
CC O76014; Q14533: KRT81; NbExp=5; IntAct=EBI-1045716, EBI-739648;
CC O76014; P78385: KRT83; NbExp=3; IntAct=EBI-1045716, EBI-10221390;
CC O76014; P78386: KRT85; NbExp=5; IntAct=EBI-1045716, EBI-1049371;
CC O76014; O43790: KRT86; NbExp=3; IntAct=EBI-1045716, EBI-9996498;
CC O76014; Q9BT17: MTG1; NbExp=3; IntAct=EBI-1045716, EBI-2602570;
CC O76014; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-1045716, EBI-1210753;
CC O76014; O43482: OIP5; NbExp=3; IntAct=EBI-1045716, EBI-536879;
CC O76014; P32242: OTX1; NbExp=3; IntAct=EBI-1045716, EBI-740446;
CC O76014; Q13526: PIN1; NbExp=3; IntAct=EBI-1045716, EBI-714158;
CC O76014; Q16512: PKN1; NbExp=3; IntAct=EBI-1045716, EBI-602382;
CC O76014; P25786: PSMA1; NbExp=3; IntAct=EBI-1045716, EBI-359352;
CC O76014; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-1045716, EBI-358489;
CC O76014; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-1045716, EBI-455078;
CC O76014; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-1045716, EBI-12018146;
CC O76014; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-1045716, EBI-6116822;
CC O76014; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-1045716, EBI-739895;
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; Y16793; CAA76389.3; -; Genomic_DNA.
DR CCDS; CCDS32653.1; -.
DR RefSeq; NP_003761.3; NM_003770.4.
DR AlphaFoldDB; O76014; -.
DR SMR; O76014; -.
DR BioGRID; 114235; 111.
DR IntAct; O76014; 43.
DR STRING; 9606.ENSP00000225550; -.
DR iPTMnet; O76014; -.
DR PhosphoSitePlus; O76014; -.
DR BioMuta; KRT37; -.
DR jPOST; O76014; -.
DR MassIVE; O76014; -.
DR PaxDb; O76014; -.
DR PeptideAtlas; O76014; -.
DR PRIDE; O76014; -.
DR ProteomicsDB; 50346; -.
DR Antibodypedia; 28843; 38 antibodies from 15 providers.
DR DNASU; 8688; -.
DR Ensembl; ENST00000225550.4; ENSP00000225550.3; ENSG00000108417.4.
DR Ensembl; ENST00000574588.1; ENSP00000458693.1; ENSG00000263022.1.
DR GeneID; 8688; -.
DR KEGG; hsa:8688; -.
DR MANE-Select; ENST00000225550.4; ENSP00000225550.3; NM_003770.5; NP_003761.3.
DR UCSC; uc002hwp.2; human.
DR CTD; 8688; -.
DR GeneCards; KRT37; -.
DR HGNC; HGNC:6455; KRT37.
DR HPA; ENSG00000108417; Tissue enriched (skin).
DR MIM; 604541; gene.
DR neXtProt; NX_O76014; -.
DR OpenTargets; ENSG00000108417; -.
DR PharmGKB; PA30244; -.
DR VEuPathDB; HostDB:ENSG00000108417; -.
DR eggNOG; ENOG502SIYJ; Eukaryota.
DR GeneTree; ENSGT00940000163444; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; O76014; -.
DR OMA; MNREHCP; -.
DR OrthoDB; 657425at2759; -.
DR PhylomeDB; O76014; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; O76014; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; O76014; -.
DR BioGRID-ORCS; 8688; 10 hits in 1065 CRISPR screens.
DR GenomeRNAi; 8688; -.
DR Pharos; O76014; Tdark.
DR PRO; PR:O76014; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O76014; protein.
DR Bgee; ENSG00000108417; Expressed in lower esophagus mucosa and 18 other tissues.
DR Genevisible; O76014; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; TAS:ProtInc.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..449
FT /note="Keratin, type I cuticular Ha7"
FT /id="PRO_0000063694"
FT DOMAIN 104..415
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..104
FT /note="Head"
FT REGION 105..139
FT /note="Coil 1A"
FT REGION 140..150
FT /note="Linker 1"
FT REGION 151..251
FT /note="Coil 1B"
FT REGION 252..267
FT /note="Linker 12"
FT REGION 268..411
FT /note="Coil 2"
FT REGION 416..449
FT /note="Tail"
FT SITE 353
FT /note="Stutter"
FT VARIANT 13
FT /note="G -> C (in dbSNP:rs9910204)"
FT /id="VAR_049795"
FT VARIANT 39
FT /note="N -> S (in dbSNP:rs9916724)"
FT /id="VAR_049796"
FT VARIANT 72
FT /note="T -> A (in dbSNP:rs9916484)"
FT /id="VAR_049797"
FT VARIANT 73
FT /note="S -> C (in dbSNP:rs9916475)"
FT /id="VAR_049798"
FT VARIANT 217
FT /note="A -> V (in dbSNP:rs16966811)"
FT /id="VAR_049799"
FT VARIANT 306
FT /note="A -> D (in dbSNP:rs2071607)"
FT /id="VAR_049800"
FT VARIANT 421
FT /note="S -> F (in dbSNP:rs35371972)"
FT /id="VAR_049801"
FT VARIANT 422
FT /note="T -> M (in dbSNP:rs8071814)"
FT /id="VAR_049802"
FT VARIANT 434
FT /note="P -> S (in dbSNP:rs17737019)"
FT /id="VAR_049803"
SQ SEQUENCE 449 AA; 49747 MW; E503974DFD8FCBAD CRC64;
MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA HANRVRVGST
PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL NGHEKETMKF LNDRLANYLE
KVRQLEQENA ELETTLLERS KCHESTVCPD YQSYFRTIEE LQQKILCSKA ENARLIVQID
NAKLAADDFR IKLESERSLH QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS
NHEQEVKILR SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE
GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRYGTELA
QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE IATYRNLLES EDCKLPCNPC
STPASCTSCP SCGPVTGGSP SGHGASMGR
