ID   KRT81_BOVIN             Reviewed;         500 AA.
AC   Q148H4;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Keratin, type II cuticular Hb1 {ECO:0000250|UniProtKB:Q14533};
DE   AltName: Full=Keratin-81 {ECO:0000312|EMBL:AAI18320.1};
DE            Short=K81;
DE   AltName: Full=Type II hair keratin Hb1;
DE   AltName: Full=Type-II keratin Kb21;
GN   Name=KRT81 {ECO:0000312|EMBL:AAI18320.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI18320.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI18320.1};
RC   TISSUE=Fetal skin {ECO:0000312|EMBL:AAI18320.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC       (acidic) and II (neutral to basic). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC118319; AAI18320.1; -; mRNA.
DR   RefSeq; NP_001069674.1; NM_001076206.1.
DR   AlphaFoldDB; Q148H4; -.
DR   SMR; Q148H4; -.
DR   STRING; 9913.ENSBTAP00000038271; -.
DR   PaxDb; Q148H4; -.
DR   PRIDE; Q148H4; -.
DR   Ensembl; ENSBTAT00000038458; ENSBTAP00000038271; ENSBTAG00000006739.
DR   GeneID; 540204; -.
DR   KEGG; bta:540204; -.
DR   CTD; 3887; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006739; -.
DR   VGNC; VGNC:50408; KRT81.
DR   eggNOG; ENOG502SKJW; Eukaryota.
DR   GeneTree; ENSGT00940000154026; -.
DR   HOGENOM; CLU_012560_5_0_1; -.
DR   InParanoid; Q148H4; -.
DR   OMA; CCESHLE; -.
DR   OrthoDB; 557821at2759; -.
DR   TreeFam; TF317854; -.
DR   Reactome; R-BTA-6805567; Keratinization.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000006739; Expressed in surface of tongue and 34 other tissues.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Isopeptide bond; Keratin;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..500
FT                   /note="Keratin, type II cuticular Hb1"
FT                   /id="PRO_0000361689"
FT   DOMAIN          106..417
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..106
FT                   /note="Head"
FT                   /evidence="ECO:0000255"
FT   REGION          107..141
FT                   /note="Coil 1A"
FT                   /evidence="ECO:0000255"
FT   REGION          142..151
FT                   /note="Linker 1"
FT                   /evidence="ECO:0000255"
FT   REGION          152..252
FT                   /note="Coil 1B"
FT                   /evidence="ECO:0000255"
FT   REGION          253..269
FT                   /note="Linker 12"
FT                   /evidence="ECO:0000255"
FT   REGION          270..413
FT                   /note="Coil 2"
FT                   /evidence="ECO:0000255"
FT   REGION          414..500
FT                   /note="Tail"
FT                   /evidence="ECO:0000255"
FT   CROSSLNK        212
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO1)"
FT                   /evidence="ECO:0000250|UniProtKB:P78386"
SQ   SEQUENCE   500 AA;  54613 MW;  0700843CF4AA659F CRC64;
     MTCGSGFRGR AFSCVSACGP RPGRCCITAA PYRGISCYRG LTGGFGSRSI CGGFRAGSFG
     RSFGYRSGGV GGLNPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KCLNNRFAAF
     IDKVRFLEQQ NKLLETKLQF YQNRQCCESN LEPLFNGYIE TLRREAECVE ADSGRLSSEL
     NSLQEVLEGY KKKYEEEVAL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR
     RLYEEEIRVL QAHISDTSVI VKMDNSRDLN MDNIVAEIKA QYDDIASRSR AEAESWYRSK
     CEEIKATVIR HGETLRRTKE EINELNRVIQ RLTAEVENAK CQNSKLEAAV TQAEQQGEAA
     LNDAKCKLAG LEEALQKAKQ DMACLLKEYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG
     VGSVNVCVSS SRGGVVCGDL CVSGSRPVTG SVCSAPCSGN LAVSTGLCAP CGPCNSVTSC
     GLGGISSCGV GSCASVCRKC