KRT82_HUMAN
ID KRT82_HUMAN Reviewed; 513 AA.
AC Q9NSB4;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 3.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Keratin, type II cuticular Hb2;
DE AltName: Full=Keratin-82;
DE Short=K82;
DE AltName: Full=Type II hair keratin Hb2;
DE AltName: Full=Type-II keratin Kb22;
GN Name=KRT82; Synonyms=KRTHB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10692104; DOI=10.1046/j.1523-1747.2000.00910.x;
RA Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.;
RT "Characterization of a 300 kbp region of human DNA containing the type II
RT hair keratin.";
RL J. Invest. Dermatol. 114:464-472(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- INTERACTION:
CC Q9NSB4; P27658: COL8A1; NbExp=3; IntAct=EBI-1045341, EBI-747133;
CC Q9NSB4; O14964: HGS; NbExp=3; IntAct=EBI-1045341, EBI-740220;
CC Q9NSB4; P49639: HOXA1; NbExp=3; IntAct=EBI-1045341, EBI-740785;
CC Q9NSB4; P19012: KRT15; NbExp=3; IntAct=EBI-1045341, EBI-739566;
CC Q9NSB4; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-1045341, EBI-3044087;
CC Q9NSB4; Q15323: KRT31; NbExp=3; IntAct=EBI-1045341, EBI-948001;
CC Q9NSB4; Q14525: KRT33B; NbExp=3; IntAct=EBI-1045341, EBI-1049638;
CC Q9NSB4; O76011: KRT34; NbExp=3; IntAct=EBI-1045341, EBI-1047093;
CC Q9NSB4; Q92764: KRT35; NbExp=3; IntAct=EBI-1045341, EBI-1058674;
CC Q9NSB4; Q6A162: KRT40; NbExp=3; IntAct=EBI-1045341, EBI-10171697;
CC Q9NSB4; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-1045341, EBI-769257;
CC Q9NSB4; Q08AM6: VAC14; NbExp=3; IntAct=EBI-1045341, EBI-2107455;
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; Y19207; CAB76827.2; -; Genomic_DNA.
DR EMBL; AC078865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS8826.1; -.
DR RefSeq; NP_149022.3; NM_033033.3.
DR AlphaFoldDB; Q9NSB4; -.
DR SMR; Q9NSB4; -.
DR BioGRID; 110086; 31.
DR ComplexPortal; CPX-5664; Keratin-80- Keratin-82 dimer complex.
DR IntAct; Q9NSB4; 16.
DR STRING; 9606.ENSP00000257974; -.
DR iPTMnet; Q9NSB4; -.
DR PhosphoSitePlus; Q9NSB4; -.
DR BioMuta; KRT82; -.
DR DMDM; 148887391; -.
DR EPD; Q9NSB4; -.
DR jPOST; Q9NSB4; -.
DR MassIVE; Q9NSB4; -.
DR PaxDb; Q9NSB4; -.
DR PeptideAtlas; Q9NSB4; -.
DR PRIDE; Q9NSB4; -.
DR ProteomicsDB; 82524; -.
DR Antibodypedia; 55914; 104 antibodies from 23 providers.
DR DNASU; 3888; -.
DR Ensembl; ENST00000257974.3; ENSP00000257974.3; ENSG00000161850.3.
DR GeneID; 3888; -.
DR KEGG; hsa:3888; -.
DR MANE-Select; ENST00000257974.3; ENSP00000257974.3; NM_033033.4; NP_149022.3.
DR UCSC; uc001sai.2; human.
DR CTD; 3888; -.
DR GeneCards; KRT82; -.
DR HGNC; HGNC:6459; KRT82.
DR HPA; ENSG00000161850; Tissue enriched (skin).
DR MIM; 601078; gene.
DR neXtProt; NX_Q9NSB4; -.
DR OpenTargets; ENSG00000161850; -.
DR PharmGKB; PA30248; -.
DR VEuPathDB; HostDB:ENSG00000161850; -.
DR eggNOG; ENOG502QWIE; Eukaryota.
DR GeneTree; ENSGT00940000161849; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q9NSB4; -.
DR OMA; CQSNIEP; -.
DR OrthoDB; 904619at2759; -.
DR PhylomeDB; Q9NSB4; -.
DR TreeFam; TF317854; -.
DR PathwayCommons; Q9NSB4; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q9NSB4; -.
DR BioGRID-ORCS; 3888; 12 hits in 1060 CRISPR screens.
DR GenomeRNAi; 3888; -.
DR Pharos; Q9NSB4; Tdark.
DR PRO; PR:Q9NSB4; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NSB4; protein.
DR Bgee; ENSG00000161850; Expressed in zone of skin and 22 other tissues.
DR Genevisible; Q9NSB4; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IDA:UniProtKB.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..513
FT /note="Keratin, type II cuticular Hb2"
FT /id="PRO_0000063697"
FT DOMAIN 120..431
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..120
FT /note="Head"
FT REGION 121..155
FT /note="Coil 1A"
FT REGION 156..165
FT /note="Linker 1"
FT REGION 166..266
FT /note="Coil 1B"
FT REGION 267..283
FT /note="Linker 12"
FT REGION 284..427
FT /note="Coil 2"
FT REGION 428..513
FT /note="Tail"
FT VARIANT 219
FT /note="E -> Q (in dbSNP:rs1791634)"
FT /id="VAR_032786"
FT VARIANT 452
FT /note="E -> D (in dbSNP:rs1732263)"
FT /id="VAR_032787"
FT VARIANT 458
FT /note="T -> M (in dbSNP:rs2658658)"
FT /id="VAR_018118"
SQ SEQUENCE 513 AA; 56653 MW; 69BB9256BB3B6587 CRC64;
MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG CLGSRSLCNV
GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES LLVPLALEID PTVQRVKRDE
KEQIKCLNNR FASFINKVRF LEQKNKLLET KWNFMQQQRC CQTNIEPIFE GYISALRRQL
DCVSGDRVRL ESELCSLQAA LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE
TNAEALVQEI DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA
SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET ENVKAQRCKL
EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL KEYQEVMNSK LGLDIEIATY
RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL
YVPCEPQGLL SCGSGRKSSM TLGAGGSSPS HKH
