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KRT82_MOUSE
ID   KRT82_MOUSE             Reviewed;         516 AA.
AC   Q99M74; Q32MV2;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Keratin, type II cuticular Hb2;
DE   AltName: Full=Keratin-82;
DE            Short=K82;
DE   AltName: Full=Type II hair keratin Hb2;
DE   AltName: Full=Type-II keratin Kb22;
GN   Name=Krt82; Synonyms=Krt2-20, Krthb2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C3H/HeN;
RX   PubMed=12399393; DOI=10.1093/genetics/162.2.831;
RA   Poirier C., Yoshiki A., Fujiwara K., Guenet J.-L., Kusakabe M.;
RT   "Hague (Hag): a new mouse hair mutation with an unstable semidominant
RT   allele.";
RL   Genetics 162:831-840(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart, Kidney, Liver, and Lung;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC       (acidic) and II (neutral to basic).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; AY028606; AAK26232.1; -; mRNA.
DR   EMBL; BC108971; AAI08972.1; -; mRNA.
DR   CCDS; CCDS27854.1; -.
DR   RefSeq; NP_444479.2; NM_053249.3.
DR   AlphaFoldDB; Q99M74; -.
DR   SMR; Q99M74; -.
DR   BioGRID; 227744; 6.
DR   ComplexPortal; CPX-5866; Keratin-80- Keratin-82 dimer complex.
DR   STRING; 10090.ENSMUSP00000023713; -.
DR   iPTMnet; Q99M74; -.
DR   PhosphoSitePlus; Q99M74; -.
DR   EPD; Q99M74; -.
DR   jPOST; Q99M74; -.
DR   PaxDb; Q99M74; -.
DR   PeptideAtlas; Q99M74; -.
DR   PRIDE; Q99M74; -.
DR   ProteomicsDB; 263679; -.
DR   Antibodypedia; 55914; 104 antibodies from 23 providers.
DR   DNASU; 114566; -.
DR   Ensembl; ENSMUST00000023713; ENSMUSP00000023713; ENSMUSG00000049548.
DR   GeneID; 114566; -.
DR   KEGG; mmu:114566; -.
DR   UCSC; uc007xtn.3; mouse.
DR   CTD; 3888; -.
DR   MGI; MGI:2149248; Krt82.
DR   VEuPathDB; HostDB:ENSMUSG00000049548; -.
DR   eggNOG; ENOG502QWIE; Eukaryota.
DR   GeneTree; ENSGT00940000161849; -.
DR   HOGENOM; CLU_012560_6_1_1; -.
DR   InParanoid; Q99M74; -.
DR   OMA; CQSNIEP; -.
DR   OrthoDB; 904619at2759; -.
DR   PhylomeDB; Q99M74; -.
DR   TreeFam; TF317854; -.
DR   Reactome; R-MMU-6805567; Keratinization.
DR   Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR   BioGRID-ORCS; 114566; 2 hits in 72 CRISPR screens.
DR   PRO; PR:Q99M74; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q99M74; protein.
DR   Bgee; ENSMUSG00000049548; Expressed in lip and 7 other tissues.
DR   Genevisible; Q99M74; MM.
DR   GO; GO:0045095; C:keratin filament; ISO:MGI.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..516
FT                   /note="Keratin, type II cuticular Hb2"
FT                   /id="PRO_0000063698"
FT   DOMAIN          118..429
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..118
FT                   /note="Head"
FT   REGION          119..153
FT                   /note="Coil 1A"
FT   REGION          154..163
FT                   /note="Linker 1"
FT   REGION          164..264
FT                   /note="Coil 1B"
FT   REGION          265..281
FT                   /note="Linker 12"
FT   REGION          282..425
FT                   /note="Coil 2"
FT   REGION          426..516
FT                   /note="Tail"
FT   CONFLICT        478
FT                   /note="N -> S (in Ref. 1; AAK26232)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   516 AA;  57140 MW;  FCA08FB6BDFB7F6E CRC64;
     MSCRNFQLSP RCGNRSFSSC SAIMPRMVTH YEVSKAPCRS GGGGGLRALG CLGSRSLCNV
     GFGRPRVASR CGMPGFGYRA GATCGSSACI TPVTINESLL VPLELEIDPT VQRVKRDEKE
     QIKCLNNRFA SFINKVRFLE QKNKLLETKW NFMQQQRSCQ SNMEPLFEGY ICALRRQLDC
     VSGDHGRLEA ELCSLQEALE GYKKKYEEEL SLRPCAENEF VTLKKDVDTA FLVKADLETN
     LEALEHEIEF LKALFEEEIG LLQSQISETS VIVKMDNSRE LDVDGIVAEI KAQYDDIASR
     SKAEAEAWYQ CRYEELRLTA GNHCDNLRNR KNEILEMNKL IQRLQQDIEA VKGQRCKLEG
     AIAQAEQQGE AALTDAKCKL AGLEEALQKA KQDMACLLKQ YQEVMNCKLG LDIEIATYRR
     LLEGEEHRLC EGIGPVNISV SSSKGAVLYE PCVMGTPMLR TEYCTGTTGV LRNSGGCNVV
     GTGELYIPCE PQGLLGCGNG RSSSMKVGVG SNSCSR
 
 
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