ID   KRT83_BOVIN             Reviewed;         493 AA.
AC   A4FUZ0;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Keratin, type II cuticular Hb3 {ECO:0000250|UniProtKB:P78385};
DE   AltName: Full=Keratin-83 {ECO:0000250|UniProtKB:P78385};
DE            Short=K83;
DE   AltName: Full=Type II hair keratin Hb3;
DE   AltName: Full=Type-II keratin Kb23;
GN   Name=KRT83 {ECO:0000312|EMBL:AAI23472.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI23472.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI23472.1};
RC   TISSUE=Fetal skin {ECO:0000312|EMBL:AAI23472.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC       (acidic) and II (neutral to basic). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC123471; AAI23472.1; -; mRNA.
DR   RefSeq; NP_001076854.1; NM_001083385.1.
DR   AlphaFoldDB; A4FUZ0; -.
DR   SMR; A4FUZ0; -.
DR   STRING; 9913.ENSBTAP00000008857; -.
DR   PaxDb; A4FUZ0; -.
DR   PeptideAtlas; A4FUZ0; -.
DR   PRIDE; A4FUZ0; -.
DR   GeneID; 507421; -.
DR   KEGG; bta:507421; -.
DR   CTD; 3889; -.
DR   eggNOG; ENOG502SKJW; Eukaryota.
DR   HOGENOM; CLU_012560_5_0_1; -.
DR   InParanoid; A4FUZ0; -.
DR   OrthoDB; 557821at2759; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Isopeptide bond; Keratin;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..493
FT                   /note="Keratin, type II cuticular Hb3"
FT                   /id="PRO_0000361691"
FT   DOMAIN          111..422
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..111
FT                   /note="Head"
FT                   /evidence="ECO:0000255"
FT   REGION          112..146
FT                   /note="Coil 1A"
FT                   /evidence="ECO:0000255"
FT   REGION          147..156
FT                   /note="Linker 1"
FT                   /evidence="ECO:0000255"
FT   REGION          157..257
FT                   /note="Coil 1B"
FT                   /evidence="ECO:0000255"
FT   REGION          258..274
FT                   /note="Linker 12"
FT                   /evidence="ECO:0000255"
FT   REGION          275..418
FT                   /note="Coil 2"
FT                   /evidence="ECO:0000255"
FT   REGION          419..493
FT                   /note="Tail"
FT                   /evidence="ECO:0000255"
FT   CROSSLNK        217
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO1)"
FT                   /evidence="ECO:0000250|UniProtKB:P78386"
SQ   SEQUENCE   493 AA;  53989 MW;  0141DC2C56E30F34 CRC64;
     MTCGFSTVGS GFGSRAFSCV SACGPRPGRC CITAAPYRGI SCYRGLTGGF GSRSVCGGFR
     AGYCSRSFGY RSGGVGGLSP PCITTVSVNE SLLTPLNLEI DPNAQCVKQE EKEQIKCLNN
     RFAAFIDKVR FLEQQNKLLE TKLQFYQNRQ CCESNLEPLF EGYIETLRRE AECVEADSGR
     LSSELNHVQE VLEGYKKKYE EEVALRATAE NEFVALKKDV DCAYIRKSDL EANSEALIQE
     IDFLRRLYEE EIRVLQANIS DTSVIVKMDN SRGLNMDNIV AEIKAQYDDI ASRSRAEAES
     WYRSKCEEIK ATVIRHGETL RRTKEEINEL NRLIQRLTAE VENAKCQNSK LEAAVTQAEQ
     QGEVALNDAR CKLAGLEEAL QKAKQDMACL LKEYQEVMNS KLGLDIEIAT YRRLLEGEEQ
     RLCEGVGAVN VCVSSSRGGV VCGDLCVSGS RPVTGSVCSA PCSGNLAVST GLCAPCGQLN
     TTCGGGSCSL GRC